%A Zhao-lan Liu, Bao-quan Liu, Lan-hua Li, Jian-ping Liu %T Introduction of dynamic balancing randomization method and its application %0 Journal Article %D 2011 %J Journal of Integrative Medicine %R 10.3736/jcim20110304 %P 246-251 %V 9 %N 3 %U {http://www.jcimjournal.com/CN/abstract/article_1588.shtml} %8 2011-03-20 %X

Following the development of clinical trials, the methodology of clinical trials has developed a great deal, including randomization method and blinding method, etc. The method of randomization includes simple randomization, stratification randomization, etc. Dynamic randomization is also considered as a method of randomization. Two dynamic randomization methods are introduced in this paper, including a method considering the balance of numbers in each group and a method considering prognostic factors. This paper also demonstrates the procedure of dynamic randomization of the above two methods by simulations and actual examples.