%A Hong-wei Gu, Zhao-hui Ni, Le-yi Gu, Yu-cheng Yan, Hui-li Dai, Ning-li Li, Min-fang Zhang, Jia-qi Qiang %T Effects of Astragalus on expression of renal angiopoietin receptor Tie-2 in diabetic rats %0 Journal Article %D 2007 %J Journal of Integrative Medicine %R 10.3736/jcim20070512 %P 536-540 %V 5 %N 5 %U {http://www.jcimjournal.com/CN/abstract/article_1858.shtml} %8 2007-09-20 %X

Objective: To study the expression of angiopoietin receptor Tie-2 in the renal tissue of diabetic rats and the effects of Astragalus.Methods: SD rats were randomly divided into normal control group, diabetes group and Astragalus-treated group. The expression of receptor Tie-2 in the renal tissue was assessed by using real-time quantitative polymerase chain reaction and immunohistochemical method.Results: Glomerule Tie-2 protein expression was significantly elevated in the diabetes group as compared with the normal control group (P<0.01). Glomerule Tie-2 protein expression in the Astragalus-treated group was decreased as compared with the diabetes group (P<0.01).Conclusion: Tie-2 may play an important role in the pathogenesis of the early stage diabetic renal injury. The reno-protection effect of Astragalus may be mediated by down-regulating the expression of Tie-2 in the kidney tissue of diabetic rats.