%A Zhen Chen, Lu-ming Liu, Yi-bei He %T Correlation between TXB2, 6-Keto-PGF1α and liver metastasis in rats model with blood stasis %0 Journal Article %D 2003 %J Journal of Integrative Medicine %R 10.3736/jcim20030316 %P 199-201 %V 1 %N 3 %U {http://www.jcimjournal.com/CN/abstract/article_747.shtml} %8 2003-09-20 %X

Objective

To observe the correlation between serum level of TXB2, 6-Keto-PGF and liver metastasis.


Methods

The metastatic model was made by injection of W256 carcinosarcoma. Rats were randomly divided into two groups: rats with blood stasis group and control group. Rats in control group were given normal saline via abdominal cavity once a day. Rats in blood stasis group were injected adrenalin in the fourteenth day. Tumor size and liver metastasis were observed. Serum TXB2 and 6-Keto-PGFwere tested by radioimmunoassay.


Results

Tumor size in rats with blood stasis was significantly smaller than that of the control group (P<0.01). Occurrence of liver metastasis in rats with blood stasis was significantly lower than that of the control group (P<0.01). The values of 6-Keto-PGF, TXB2, and TXB2/6-Keto-PGF were higher in the group with blood stasis.


Conclusion

In the status of blood stasis, W256 carcinosarcoma grows slowly, and liver metastasis increases insignificantly, with the elevations of 6-Keto-PGF, TXB2 and TXB2/6-Keto-PGF1α.