%A Jian-hui Tian, Zhi-ming Shi, Zhi-yi Zhou, Yun-sheng Huang, Lin Wang %T Effects of Feiji Formula on lung cancer metastasis in mice %0 Journal Article %D 2008 %J Journal of Integrative Medicine %R 10.3736/jcim20080811 %P 827-829 %V 6 %N 8 %U {http://www.jcimjournal.com/CN/abstract/article_806.shtml} %8 2008-08-20 %X

Objective: To observe the effects of Feiji Formula, a compound traditional Chinese herbal medicine, on lung cancer metastasis in mice.
Methods: The lung cancer metastasis model of mice was established in this experiment study. Twenty-four mice were randomly divided into three groups: untreated group, cisplatin group and Feiji Formula group. Mice in the Feiji Formula group were treated with Feiji Formula decoction; in cisplatin group, with cisplatin by intraperitoneal injection; and in the untreated group, with normal saline (NS). After twenty-day treatment, the body and tumor weights as well as the number of metastatic tumors in both lungs of each mouse were measured.
Results: The body weight of mice in cisplatin group was significantly less than that of Feiji Formula group and untreated group (P<0.01); the tumor weight of mice in cisplatin group and Feiji Formula group was markedly lower than that of untreated group (P<0.01); and the number of metastatic tumors in cisplatin group and Feiji Formula group was markedly lower than that of the untreated group (P<0.01), no significant difference between the Feiji Formula group and cisplatin group in terms of the weights and the numbers of metastatic tumors in bilateral lungs.
Conclusion: Feiji Formula can suppress tumor growth and decrease the number of lung metastatic tnmors in the mice, and maintain the body weight of the mice.