%A Jing-zhe Zhang, Xue-lin Zhang, Xiao-qiang Liang, Hong-gang Gu, Pei-ting Zhu %T Effects of different Chinese herbal medicines on biochemical parameters in guinea-pig with pigment gallstones %0 Journal Article %D 2008 %J Journal of Integrative Medicine %R 10.3736/jcim20080816 %P 856-859 %V 6 %N 8 %U {http://www.jcimjournal.com/CN/abstract/article_811.shtml} %8 2008-08-20 %X

Objective: To observe the effects of Qingdan Capsule (QDC) and Yanggan Lidan Granule (YGLDG), two kinds of compound traditional Chinese herbal medicines, on biochemical parameters in guinea-pigs with pigment gallstones.
Methods: An animal model of pigment gallstones was established in male guinea-pigs by hypodermic injection of lincomycin. The guinea-pigs were randomly divided into blank control group, untreated group, QDC group and YGLDG group. There were 8 guinea-pigs in each group. After ten-day treatment, animals were sacrificed and sampled to calculate the rate of stone formation, total bilirubin (TB), unconjugated bilirubin (UCB) and Ca2+ density in bile of the four groups.
Results: In comparison with the untreated group, the rates of stone formation in the QDC and YGLDG groups were significantly decreased (P<0.01). TBIL, UCB and Ca2+ content of bile in both QDC and YGLD groups was also significantly decreased (P<0.05, P<0.01).
Conclusion: QDC and YGLD have good effects on biochemical changes of animal model of pigment gallstone in reversing the lithogenesity of bile by reducing the content of TB, UCB and Ca2+, hence resulting in clinical treatment and prevention of pigment gallstone disease.