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Original Clinical Research
Journal of Chinese Integrative Medicine: Volume 7   July, 2009   Number 7

DOI: 10.3736/jcim20090703
Effects of Feitai Capsule on quality of life in patients with advanced non-small-cell lung cancer: a randomized controlled trial
1. Zhi-zhen LIU (Department of Oncology, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China )
2. Zong-yang YU (Department of Oncology, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China )
3. Xue-nogn OUYANG (Department of Oncology, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China E-mail: oyxn@pulic.fz.fj.cn)
4. Xi-hu DAI (Department of Oncology, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China )
5. Xi CHEN (Department of Oncology, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China )
6. Zhong-quan ZHAO (Department of Oncology, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China )
7. Wen-wu WANG (Department of Oncology, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China )
8. Jie LI (Department of Oncology, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China )
9. Hua TU (Department of Oncology, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China )
10. Lei YE (Department of Oncology, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China )
11. Yan YAN (Department of Oncology, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China )

Background: Recently the maintenance therapy of non-small-cell lung cancer (NSCLC) patients who completed required treatment cycles has caused widespread interests in the medical field. Traditional Chinese medicine may be a useful complement in maintenance treatment of mid-to-late stage NSCLC.
Objective: To observe the effects of Feitai Capsule, a compound traditional Chinese herbal medicine for expelling blood stasis and phlegm, on the quality of life of the NSCLC patients as a maintenance treatment.
Design, setting, participants and interventions: A total of 62 mid-to-late stage NSCLC patients from Fuzhou General Hospital of Nanjing Military Region were included and randomly divided into treatment group (31 cases) and control group (31 cases). Patients in the treatment group were treated with Feitai Capsule, and patients in the control group did not accept any intervention. Regular observations and follow-up were performed for patients in the two groups.
Main outcome measures: Analysis of variance, nonparametric test, and analysis of covariance were used to compare clinical features, amelioration of clinical symptoms, physical constitution and energy, and quality of life.
Results: There were two dropouts and 60 valid cases. The baseline characteristics of the two groups were similar. In the treatment group, symptom response and physical energy level were improved by 36.6% (Z=
-2.632, P=0.008) and 26.7% (Z=-2.182, P=0.029), respectively. There was a positive correlation between these two factors (r=0.917, P<0.001). The patients in treatment group had a significantly improved quality of life after treatment. No serious adverse events were observed.
Conclusion: Feitai Capsule as maintenance treatment can improve the quality of life of the patients with mid-to-late stage NSCLC.

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Liu ZZ, Yu ZY, Ouyang XN, Dai XH, Chen X, Zhao ZQ, Wang WW, Li J, Tu H, Ye L, Yan Y. J Chin Integr Med. 2009; 7(7): 611-615. Received December 22, 2008; accepted April 27, 2009; published online July 15, 2009. Indexed/abstracted in and full text link-out at PubMed. Journal title in PubMed: Zhong Xi Yi Jie He Xue Bao. Free full text (HTML and PDF) is available at www.jcimjournal.com. Forward linking and reference linking via CrossRef. DOI: 10.3736/jcim20090703

 

Correspondence: Xue-nong OUYANG, MD, Professor; Tel: 0591-83787037; E-mail: oyxn@pulic.fz.fj.cn

 

Full text of this article is in Chinese.

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