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Original Experimental Research
Journal of Chinese Integrative Medicine: Volume 7   July, 2009   Number 7

DOI: 10.3736/jcim20090712
Antidepressant effects of piperine and its neuroprotective mechanism in rats
1. Yuan HU (Department of Clinical Pharmacology and Pharmacy, General Hospital of People's Liberation Army of China, Beijing 100853, China )
2. Hong-bo LIAO (Department of Clinical Pharmacology and Pharmacy, General Hospital of People's Liberation Army of China, Beijing 100853, China )
3. Ping LIU (Department of Clinical Pharmacology and Pharmacy, General Hospital of People's Liberation Army of China, Beijing 100853, China E-mail: liuping126@126.com)
4. Dai-hong GUO (Department of Clinical Pharmacology and Pharmacy, General Hospital of People's Liberation Army of China, Beijing 100853, China )
5. Yu-yu WANG (Department of Clinical Pharmacology and Pharmacy, General Hospital of People's Liberation Army of China, Beijing 100853, China )
Objective: To study the antidepressant effects of piperine in chronic unpredictable mild stress (CUMS) rats and to explore the underlying mechanisms in the hypothalamic-pituitary-adrenal (HPA) axis.
Methods: Fifty rats were housed alone and exposed to an unpredicted sequence of mild stressors to induce CUMS, and then were divided into untreated group, desipramine group and low-, medium- and high-dose piperine groups. Another 10 normal rats were used as normal control. The behavior of the rats was detected by body weight and sucrose preference test, and the serum levels of corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and corticosterone (CORT) in different groups were observed by radioimmunoassay.
Results: The results indicated that after 21-day administration, piperine at concentrations of 10 and 20 mg/kg could significantly improve the behavioral disorder by increasing sucrose consumption. Piperione at concentrations of 5, 10 and 20 mg/kg could remarkably reduce serum ACTH and CRH levels in the CUMS rats, but had little effect on the content of CORT.
Conclusion: Piperine can relieve depression in CUMS rats by modulating the function of HPA axis.
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Hu Y, Liao HB, Liu P, Guo DH, Wang YY. J Chin Integr Med. 2009; 7(7): 667-670. Received April 22, 2009; accepted May 31, 2009; published online July 15, 2009. Indexed/abstracted in and full text link-out at PubMed. Journal title in PubMed: Zhong Xi Yi Jie He Xue Bao. Free full text (HTML and PDF) is available at www.jcimjournal.com. Forward linking and reference linking via CrossRef. DOI: 10.3736/jcim20090712 

 

Correspondence: Ping LIU, MD, Professor; Tel: 010-663936676; E-mail: liuping126@126.com

 

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References
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