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Journal of Chinese Integrative Medicine: 2008; 6(7): 711-715
DOI: 10.3736/jcim20080710
Effects of curcumin on secretion of adiponectin and interleukin-6 in human adipose tissues: an in vitro study
1. Xiao-bing QU (Department of Geriatrics, the Second Xiangya Hospital, Central South University, Changsha, Hunan Province 410011, China E-mail: quxiaobing1@163.com)
2. Shui-ping ZHAO (Department of Cardiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan Province 410011, China )
3. Jing XU (Department of Emergency, the First Affiliated Hospital, Hunan Normal University, Changsha, Hunan Province 410006, China )
4. Li-ni DONG1 (Department of Geriatrics, the Second Xiangya Hospital, Central South University, Changsha, Hunan Province 410011, China )

Objective: To investigate the effects of different concentrations of curcumin on secretion of adiponectin (APN) and interleukin-6 (IL-6) in human adipose tissues cultivated in vitro.

Methods: Seven male patients with kidney stones were admitted. Abdominal subcutaneous adipose tissue and perirenal adipose tissue were collected from the operating-patients, and were cultivated with different concentrations of curcumin (10 and 100 μg/ml) in vitro. The contents of APN and IL-6 in the culture medium of adipose tissue cells were measured by enzyme-linked immunosorbent assay (ELISA) after they were cultured for 6 and 24 hours.

Results: Compared with the blank control group, the content of APN in the adipose tissue culture medium was increased by 100 μg/ml curcumin (P<0.05) after 6-hour culture, and the content of IL-6 was significantly decreased by 100 μg/ml curcumin after 6- and 24-hour culture (P<0.05).

Conclusion: 100 μg/ml curcumin can increase APN secretion and decrease IL-6 secretion in human adipose tissues cultivated in vitro.

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Please cite this article as:
Qu XB, Zhao SP, Xu J, Dong LN. Effects of curcumin on secretion of adiponectin and interleukin-6 in human adipose tissues: an in vitro study. J Chin Integr Med / Zhong Xi Yi Jie He Xue Bao. 2008; 6(7): 711-715.
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