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Journal of Chinese Integrative Medicine: 2004; 2(4): 281-284
DOI: 10.3736/jcim20040415
Effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental precancerous lesion and its mechanism
1. CHEN Zuo-Liang (Xiamen Hospital of Stomatalogy, Xiamen, Fujian Province 361001, China E-mail: zuoliangc@yahoo.com.cn)
2. GUAN Yu-Qin (Xiamen Hospital of Stomatalogy, Xiamen, Fujian Province 361001, China )
3. CHEN Xi (School of Stomatalogy, Wuhan University, Wuhan, Hubei Province 430079, China )
4. CHEN Xiao-Ling (Xiamen Hospital of Stomatalogy, Xiamen, Fujian Province 361001, China )
5. CHEN Jin-Chun (Department of Internal Medicine, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, Fujian Province 361001, China )

Objective: To study the effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental oral precancerous lesion and its mechanism.

Methods: We treated the experimental oral precancerous lesion in hamster's cheek pouch using 1023 Recipe (consisting of Radix Astragali, Gynostemma Pentaphyllum, Rhizoma Chuanxiong and selenium-rich green tea) for 6 weeks, and observed its effect in blocking cancer transformation, detected 2 kinds of agglutinin receptors (receptors of wheat germ agglutinin and Ricinus communis agglutinin) in the mucosa of the hamster's cheek pouch.

Results: The rate of cancer transformation in 1023 Recipe treated group was lower than that in the control group without treatment (P<0.05). Agglutinin receptors in the two groups were different significantly.

Conclusion: 1023 Recipe is effective in treating hyperplasia, and can prevent its cancer transformation. The mechanism may be that 1023 Recipe can induce precancerous lesions to differentiate into normal tissues.

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Please cite this article as:
Chen ZL, Guan YQ, Chen X, Chen XL, Chen JC. Effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental precancerous lesion and its mechanism. J Chin Integr Med / Zhong Xi Yi Jie He Xue Bao. 2004; 2(4): 281-284.
References:
1陈作良, 官玉芹, 李辉奉, 等. 1023合剂对实验性口腔癌的抑瘤及阻癌的正交实验研究[J].中华口腔医学杂志, 1998, 33(1): 50-52.  .
2陈作良, 官玉芹, 陈宏柏, 等. 1023中药合剂健身防癌作用的动物实验研究[J].临床口腔医学杂志, 2001, 17(1): 57-58.  .
3陈作良, 官玉芹, 陈新明, 等. 实验性动物癌前损害和癌的凝集素受体变化的研究[J].口腔医学, 1997, 17(2): 67-69.  .
4周曾同, 张水龙, 李伟国, 等. 复方绞股蓝对金黄地鼠颊囊癌前病变的疗效观察[J].上海口腔医学, 1996, 5(2): 74-76.  .
5钟余才. 绞股蓝药用研究进展[J].广西中医药, 1991, 14(3): 138-139.  .
6颜学先, 王鼎年. 硒与肿瘤:Ⅲ.植瘤小鼠给抑瘤剂量硒后胞浆中75Se的分布与含硒蛋白变化[J].重庆医科大学学报, 1989, 14(2): 85-89.  .
7阮萃才, 梁远, 刘宗河. 茶叶的抗突变作用[J].广西医学院学报, 1988, 8(4): 27-30.  .
8杜志德, 来玉梅. 黄芪的免疫作用研究进展[J].中草药, 1988, 19(9): 40-42.  .

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