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Journal of Chinese Integrative Medicine: 2017; 15(2): 77–87
DOI: 10.1016/S2095-4964(17)60313-3
Potential application of the Kampo medicine goshajinkigan for prevention of chemotherapy-induced peripheral neuropathy
1. Marco Cascella (Division of Anesthesia, Department of Anesthesia and Pain Medicine, Istituto Nazionale Tumori “Fondazione G. Pascale”—IRCCS, via Mariano Semmola, Naples 80131, Italy )
2. Maria Rosaria Muzio (Division of Infantile Neuropsychiatry, UOMI-Maternal and Infant Health, Asl NA 3 SUD, Torre del Greco, via Marconi, Naples 80059, Italy )


Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common and severe adverse effects related to cancer treatment. Unfortunately, although several agents and protocols have been proposed, no prophylactic strategies have yet to be proven useful. Therefore, new alternative therapies have been considered for CIPN prevention. Herbal medicine in Japan, called Kampo medicine, is derived from traditional Chinese medicine. Goshajinkigan (GJG) is a Kampo medicine, that is comprised of ten herbs. The aim of this work is to analyse the results of pre-clinical and clinical studies on the potential applications of GJG in CIPN prevention.

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Cascella M, Muzio MR. Potential application of the Kampo medicine goshajinkigan for prevention of chemotherapy-induced peripheral neuropathy. J Integr Med. 2017; 15(2): 77–87.
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