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Journal of Chinese Integrative Medicine: 2009; 7(7): 616-621
DOI: 10.3736/jcim20090704
Therapy for replenishing qi, nourishing yin and promoting blood circulation in patients with acute myocardial infarction undergoing percutaneous coronary intervention: a randomized controlled trial
1. Sheng-lei QIU (Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital University of Medical Sciences, Beijing 100010, China )
2. Mei JIN (Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital University of Medical Sciences, Beijing 100010, China E-mail: jinmei622@yahoo.com.cn)
3. Jing-hong YI (Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital University of Medical Sciences, Beijing 100010, China )
4. Tian-gang ZHU (Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital University of Medical Sciences, Beijing 100010, China )
5. Xin QUAN (Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital University of Medical Sciences, Beijing 100010, China )
6. Yan LIANG (Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital University of Medical Sciences, Beijing 100010, China )
Background: No-reflow phenomenon after reperfusion treatment of acute myocardial infarction (AMI) is becoming more recognized today. The effective treatment for no-reflow has not been reported.
Objective: To observe the effects of traditional Chinese medicine (TCM) therapy for replenishing qi, nourishing yin, and promoting blood circulation on AMI patients undergoing percutaneous coronary intervention (PCI).
Design, setting, participants and interventions: This study was conducted from January 2005 to March 2006 using a double-blinded, randomized method. Thirty-five AMI patients (KillipⅠ-Ⅱ) were first diagnosed as ST segment elevation AMI and obtained primary PCI. They were recruited from People’s Hospital, Peking University. All patients’ symptoms accorded with qi-yin deficiency syndrome and blood stasis syndrome. They were randomly and double blindly divided into control group (18 cases) and treatment group (17 cases). The patients in the control group received Western medicine treatment, and the patients in the treatment group were treated with Western medicine plus American ginseng and Salviae miltiorrhizae preparations. They were all treated for 3 months.
Main outcome measures: Before and after 3-month treatment, the TCM symptoms were observed and scored. At the state of baseline and dobutamine stress, left ventricular ejection fraction (LVEF), wall motion score (WMS), WMS index and normal cardiac muscle percentage (NCMP), and the myocardial contrast echocardiography index k, which reflects myocardium microcirculation perfusion, were detected.
Results: After 3-month treatment, the TCM symptoms in the treatment group were improved as compared with the control group (χ2
4.118, P0.042). At the state of dobutamine stress, LVEF in the treatment group after treatment was higher than those in the control group (t2.130, P0.041) and before treatment (t2.345, P0.032). Although the number of the segments with increased k value was more than that in the control group, there was no significant difference.
Conclusion: TCM therapy for replenishing qi, nourishing yin and promoting blood circulation can improve the clinical symptoms and quality of life of the AMI patients undergoing PCI, and is beneficial to myocardium microcirculation. Thus, it may be an alternative cardioprotective treatment strategy for successful myocardial microcirculation in AMI patients after reperfusion.
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Please cite this article as:
Qiu SL, Jin M, Yi JH, Zhu TG, Quan X, Liang Y. Therapy for replenishing qi, nourishing yin and promoting blood circu-lation in patients with acute myocardial infarction undergoing percu-taneous coronary intervention: a randomized controlled trial. J Chin Integr Med / Zhong Xi Yi Jie He Xue Bao. 2009; 7(7): 616-621.
References:
1Society of Cardiology of Chinese Medical Association, Editor Committee of Chinese Journal of Cardiology, Editor Committee of Chinese Circulation Journal. Guidelines for diagnosis and treatment of acute myocardial infarction[J].Zhongguo Xun Huan Za Zhi, 2001, 16(6): 407-422. Chinese.
2North-east Subgroup of the Collaboration Group of Thoracic Obstruction Emergency, Bureau of Medical Administration of State Administration of Traditional Chinese Medicine. Standards of diagnosis and treatment of thoracic obstruction (myocardial infarction)[J].Zhongguo Zhong Yi Ji Zheng, 1995, 4(4): 183-185. Chinese.
3Yan HB, Zhu XL. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (revised edition)[M]. Beijing: China Environment Science Publishing House, 2004. 9-186. Chinese.
4Zheng XY. Guidelines of clinical research on Chinese new herbal medicines[M]. Beijing: Medical Science and Technology Publishing House of China, 2002. 72-78. Chinese.
5Shi YS, Zhang HX, Huang TG. Practice of coronary cardiology[M]. 4th ed. Tianjin: Tianjin Science & Technology Translation & Publishing Corporation, 2005. 974-975. Chinese.
6Wang CL, Shi DZ, Yin HJ, Chen KJ. Effect of Panax quinquefolius saponin on angiogenesis and expressions of VEGF and bFGF in myocardium of rats with acute myocardial infarction[J].Zhongguo Zhong Xi Yi Jie He Za Zhi, 2007, 27(4): 331-334. Chinese with abstract in English.
7Ji HG, Si L, Si XC, Zhang Q. Research advances of protective effect of Danshen against myocardial ischemia and reperfusion injury[J].Guang Ming Zhong Yi, 2006, 21(3): 52-53. Chinese.
8Hou XL, Li BL, Zhao L, Huang SD, Xu ZY, Zhang GX. Effects of Xuefu Zhuyu Capsule on endothelin-1 release in myocardium and vascular endothelium and nitric oxide/nitric oxide synthase system of swines after acute myocardial infarction and reperfusion[J]. J Chin Integr Med, 2008, 6(4): 381-386. Chinese with abstract in English.
9Tang H, Xie JM. Clinical trend on myocardial contrast echocardiography[J].Zhongguo Yi Liao Qi Xie Xin Xi, 2006, 12(2): 10-12. Chinese with abstract in English.
10Senior R, Janardhanan R, Jeetley P, Burden L. Myocardial contrast echocardiography for distinguishing ischemic from nonischemic first-onset acute heart failure: insights into the mechanism of acute heart failure[J].Circulation, 2005, 112(11): 1587-1593.  .
11Guo SZ, Shu XH, Pan CZ, Li YL, Ge JB, Chen HZ. Value of low dose dobutamine real-time myocardial contrast echocardiography in the assessment of coronary artery disease[J].Zhonghua Xin Xue Guan Bing Za Zhi, 2005, 33(5): 419-424. Chinese with abstract in English.
12Yan H, Zhang J, Yang XC. Tissue Doppler imaging in acute myocardial infarction[J].Xin Xue Guan Bing Jin Zhan, 2005, 26(4): 402-404. Chinese with abstract in English.

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