Home | Current Issue | Past Issues | Search | CollectionsRSS | PDA Services | FAQ | SHCIM Online | Chinese Updated Wednesday, September 28, 2016
 Services
Submit a manuscript
Subscribe
Individuals
Institutions
Response
Send response
Read responses
Reprint
Advance online publication
Sign up for e-alert
JCIM job opportunities
Contact JCIM
 Information For
Readers
Authors
Reviewers
Advertisers
 About JCIM
Journal description
Editorial policy
Privacy policy
Copy right
Editorial staff
 Language Polishing
Journal of Chinese Integrative Medicine: 2010; 8(3): 238-243
DOI: 10.3736/jcim20100307
Analysis of relationships among syndrome, therapeutic treatment, and Chinese herbal medicine in patients with coronary artery disease based on complex networks
1. Zhu-ye GAO (Department of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China )
2. Zhu-ye GAO (Department of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China )
3. Hao XU (National Integrative Medicine Center of Cardiovascular Diseases, China-Japan Friendship Hospital, Beijing 100029, China E-mail: xuhao2005@sohu.com)
4. Da-zhuo SHI (Department of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China )
5. Chang-geng FU (Department of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China )
6. Dan QU (National Integrative Medicine Center of Cardiovascular Diseases, China-Japan Friendship Hospital, Beijing 100029, China )
7. Xue-zhong ZHOU (College of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, China )
Objective: To analyze the relationships among syndrome, therapeutic method and Chinese herbal medicine in patients with coronary artery disease (CAD).
Methods: Using cross-sectional survey, we collected the clinical information of hospitalized CAD patients through individualized Information Acquisition Platform of CAD. The relationships among syndrome, therapeutic treatment and Chinese herbs were excavated by means of complex networks based on theory of correspondence between prescription and syndrome.
Results: The fundamental syndrome factors were blood stasis, qi deficiency, phlegm-turbid, yin deficiency, yang deficiency, qi stagnation, and blood deficiency. The therapeutic treatment mainly included activating blood circulation, clearing heat, invigorating qi, resolving turbid and phlegm, nourishing yin, warming yang qi, and dispersing obstruction. These methods constituted an association with major syndrome factors. The major syndrome factors constituted an association with the following Chinese herbal medicines: Huangqi (Radix Astragali Mongolici), Chenpi (Pericarpium Citri Reticulatae), Dihuang (Radix Rehmanniae), Chuanxiong (Rhizoma Chuanxiong), Baizhu (Rhizoma Atractylodis Macrocephalae), Taoren (Semen Persicae), Fuling (Poria), Gancao (Radix Glycyrrhizae), Banxia (Rhizoma Pinelliae), Zexie (Rhizoma Alismatis), Chishao (Radix Paeoniae Rubra), Danggui (Radix Angelicae Sinensis), Danshen (Radix Salviae Miltiorrhizae), Zhiqiao (Fructus Aurantii Submaturus.), Guizhi (Ramulus Cinnamomi) and Maidong (Radix Ophiopogonis Japonici). The efficacy of Chinese berbal medicines constituting association with syndrome factors mainly included alleviating pain, resolving turbid and phlegm, clearing heat, activating blood circulation, invigorating qi, cooling blood, promoting urination, resolving stagnation, removing toxic material, nourishing blood, regulating qi, quieting spirit, invigorating spleen, regulating menstruation, promoting defecation, moistening dryness, and resolving stasis.
Conclusion: The therapeutic methods for CAD are based on consistency in theory, method, formula and medicines. Therapeutic methods for clearing heat and removing toxical material should be further studied.
Welcome to JCIM! You are the number 13065 reader of this article!
Download Article:
[Full Text]      [PDF]      [Chinese]      [Previous]      [Next]      [This Issue]
Please cite this article as:
Gao ZY, Zhang JC, Xu H, Shi DZ, Fu CG, Qu D, Zhou XZ. Analysis of relationships among syndrome, therapeutic treatment, and Chinese herbal medicine in patients with coronary artery disease based on complex networks. J Chin Integr Med / Zhong Xi Yi Jie He Xue Bao. 2010; 8(3): 238-243.
References:
1Hou C. Exploration on the essence of TCM syndrome with systems approach[J].Zhongguo Zhong Xi Yi Jie He Za Zhi, 2007, 27(5): 461-465. Chinese with abstract in English.
2Shen ZY. Studies of gene networks and singal transduction of kidney deficiency syndrome by syndrome differentiation through drug effects[J].Zhongguo Zhong Xi Yi Jie He Za Zhi, 2005, 25(12): 1125-1128. Chinese with abstract in English.
3González MC, Barabási AL. Complex networks: from data to models[J].Nat Phys, 2007, 3(4): 224-225.  .
4Xie YH, Zhang JC, Chen KJ. Corresponding relationship between prescription and syndrome in traditional Chinese medicial practice[J].Zhong Xi Yi Jie He Xin Nao Xue Guan Bing Za Zhi, 2008, 6(1): 1-2. Chinese with abstract in English.
5Dou ZF, Guo L, Zhang JL, Zhang X. Thinking about studies on “correspondence between recipe and syndrome”[J].Zhong Yi Za Zhi, 2006, 47(8): 563-564, 570. Chinese with abstract in English.
6Gibbons RJ, Abrams J, Chatterjee K, Daley J, Deedwania PC, Douglas JS, Ferguson TB Jr, Fihn SD, Fraker TD Jr, Gardin JM, O’Rourke RA, Pasternak RC, Williams SV, Gibbons RJ, Alpert JS, Antman EM, Hiratzka LF, Fuster V, Faxon DP, Gregoratos G, Jacobs AK, Smith SC Jr, American College of Cardiology, American Heart Association Task Force on Practice Guidelines, Committee on the Management of Patients With Chronic Stable Angina. ACC/AHA 2002 guideline update for the management of patients with chronic stable angina — summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Chronic Stable Angina)[J].Circulation, 2003, 107(1): 149-158.  .
7Liao XX, Ma H. Guidelines for the management of patients with chronic stable angina (1999): American College of Cardiology/American Heart Association/ American College of Physician-American Society of Internal Medicine[J].Lingnan Xin Xue Guan Bing Za Zhi, 2000, 6(3): 215-216. Chinese.
8Society of Cardiology of Chinese Medical Association, Editorial Committee of Chinese Journal of Cardiology. Diagnosis and treatment recommendations of unstable angina[J].Zhonghua Xin Xue Guan Bing Za Zhi, 2000, 28(6): 409-412. Chinese.
9Society of Cardiology of Chinese Medical Association, Editorial Committee of Chinese Journal of Cardiology, Editorial Committee of Chinese Circulation Journal. Guidelines for diagnosis and treatment of acute myocardial infarction[J].Zhonghua Xin Xue Guan Bing Za Zhi, 2001, 29(12): 710-725. Chinese.
10Professional Committee of Cardiology, Chinese Association of Integrative Medicine. The standard of syndrome differentiation for coronary heart disease[J].Zhong Xi Yi Jie He Za Zhi, 1991, 11(5): 257. Chinese.
11Gao XM. Chinese materia medica[M]. Beijing: China Press of Traditional Chinese Medicine, 2004. 8-592. Chinese.
12Zhou XZ, Liu BY, Wang YH, Zhang RS, Yao NL, Cui M. Study of method on Chinese herbal compound compatibility by complex networks[J].Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2008, 15(11): 98-100. Chinese.
13Ni Q, Chen SB, Zhou XZ, Wei ZX, Gao YB, Li Y, Wang XM, Li P, Lin L, Liu BY. Study of relationship between formula (herbs) and syndrome about type 2 diabetes mellitus affiliated metablic syndrome based on the free-scale network[J].Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2006, 13(11): 19-22. Chinese with abstract in English.
14Ortega GJ, Sola RG, Pastor J. Complex network analysis of human ECoG data[J].Neurosci Lett, 2008, 447(2-3): 129-133.  .
15Boccaletti S, Latora V, Moreno Y, Chavezf M, Hwanga DU. Complex networks: structure and dynamics[J].Phys Rep, 2006, 424(4-5): 175-308.  .
16Feng Y, Wu Z, Zhou X, Zhou Z, Fan W. Knowledge discovery in traditional Chinese medicine: state of the art and perspectives[J].Artif Intell Med, 2006, 38(3): 219-236.  .
17Gao ZY, Xu H, Chen KJ, Shi DZ, Li LZ, Zhou XZ. Efficacy evaluation of Shengmai Injection in treating coronary heart disease based on random walk model[J]. J Chin Integr Med, 2008, 6(9): 902-906. Chinese with abstract in English.
18Zhang JC, Chen KJ. Theoretical thinking on relationship between toxic-stasis pathogenicity and atherosclerotic vulnerable plaque[J].Zhongguo Zhong Xi Yi Jie He Za Zhi, 2008, 28(4): 366-368. Chinese with abstract in English.
19Xu H, Shi DZ, Yin HJ, Zhang JC, Chen KJ. Blood-stasis and toxin causing catastrophe hypothesis and acute cardiovascular events: proposal of the hypothesis and its clinical significance[J].Zhongguo Zhong Xi Yi Jie He Za Zhi, 2008, 28(10): 934-938. Chinese with abstract in English.
20Shi DZ, Xu H, Yin HJ, Zhang JC, Chen KJ. Combination and transformation of toxin and blood stasis in etiopatho-genesis of thrombotic cerebrocardiovascular diseases[J]. J Chin Integr Med, 2008, 6(11): 1105-1108. Chinese with abstract in English.

 Home | Current Issue | Past Issues | Search | CollectionsRSS | PDA Services | FAQ | SHCIM Online | Chinese
Copyright © 2003-2012 by JCIM Press. All rights reserved. ISSN 1672-1977