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Journal of Chinese Integrative Medicine: 2013; 11(3): 175-183
DOI: 10.3736/jintegrmed2013032
Effects of Chinese herbal medicine Yiqi Huaju Qingli Formula in metabolic syndrome patients with microalbuminuria: a randomized placebo-controlled trial
1. Tian-zhan Wang (Institute of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China )
2. Yu Chen (Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China )
3. Yan-ming He (Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China )
4. Xiao-dong Fu (Institute of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China )
5. Yi Wang (Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China )
6. Yan-qiu Xu (Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China )
7. Hong-jie Yang (Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China )
8. Hong-li Xue (Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China )
9. Yi Liu (Institute of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China )
10. Xiao-tao Feng (Guangxi Scientifc Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China )
11. Teng Zhang (Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China E-mail: zhangteng501@hotmail.)
12. Wen-jian Wang (Institute of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China E-mail: wj6518@163.com)

BACKGROUND: Microalbuminuria (MAU) is a key component of metabolic syndrome (MetS) and is an early sign of diabetic nephropathy as well. Although routine Western medicine treatments are given to MetS patients to control high blood pressure, hyperglycemia and dyslipidemia, some patients still experience progressive renal lesions and it is necessary to modify and improve the treatment strategy for MetS patients.

OBJECTIVE: To investigate the efficacy of Yiqi Huaju Qingli Herb Formula, a compound traditional Chinese herbal medicine, in MetS patients with MAU when it is combined with routine Western medicine treatment.

DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: Sixty patients with MetS were randomized into the Chinese herbal formula group (CHF, Yiqi Huaju Qingli formula treatment in combination with Western medicine) and control group (placebo in combination with Western medicine). All treatments were administered for 12 weeks.

MAIN OUTCOME MEASURES: Urinary microalbumin (MA), urinary albumin-to-creatinine ratio (UACR), 24-hour total urine protein (24-hTP), body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2-hPPG), glycosylated hemoglobin (HbA1c), homeostasis model assessment for insulin resistance (HOMA-IR), blood lipid profile and blood pressure were observed.

RESULTS: Compared with the control group, CHF treatment significantly decreased BMI (P<0.05), WC (P<0.01) and WHR (P<0.01). Both groups had significant decreases in FPG, 2-hPPG, HbA1c, HOMA-IR, MA, and UACR, with CHF treatment showing better effects on these parameters compared with the control treatment (P<0.05). Both treatments significantly reduced the levels of total cholesterol, low-density lipoprotein cholesterol and triacylglycerol (TAG), and a greater reduction in TAG was observed with CHF treatment (P<0.05). The level of high-density lipoprotein cholesterol did not change in the control group after treatment (P>0.05), whereas it significantly increased with CHF treatment (P<0.01). Compared with before the treatment, significant decreases in systolic blood pressure, diastolic blood pressure and mean arterial blood pressure were observed in both groups (P<0.01). However, there was no significant difference between the two groups (P>0.05).

CONCLUSION: Combined treatment of Yiqi Huaju Qingli Formula and Western medicine significantly alleviated MAU, which may correlate with the improvement of insulin sensitivity and glucose and lipid metabolism.

TRIAL REGISTRATION IDENTIFIER: This trial was registered in the Chinese Clinical Trial Registry with the identifier ChiCTR-TRC-11001633. KEYWORDS: metabolic syndrome X; microalbuminuria; insulin resistance; drugs, Chinese herbal; randomized controlled trials

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Please cite this article as:
Wang TZ, Chen Y, He YM, Fu XD, Wang Y, Xu YQ, Yang HJ, Xue HL, Liu Y, Feng XT, Zhang T, Wang WJ. Effects of Chinese herbal medicine Yiqi Huaju Qingli Formula in metabolic syndrome patients with microalbuminuria: a randomized placebo-controlled trial. J Integr Med. 2013; 11(3): 175-183.
References:
1Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation[J].Diabet Med, 1998, 15(7): 539-553.  .
2Schrijvers BF, De Vriese AS, Flyvbjerg A. From hyperglycemia to diabetic kidney disease: the role of metabolic, hemodynamic, intracellular factors and growth factors/cytokines[J].Endocr Rev, 2004, 25(6): 971-1010.  .
3Khosla N, Sarafidis PA, Bakris GL. Microalbuminuria[J].Clin Lab Med, 2006, 26(3): 635-653.  .
4He CY, Wang WJ, Li B, Xu DS, Chen WH, Ying J, He YM. Clinical research of Yiqi Sanju Formula in treating central obese men at high risk of metabolic syndrome[J]. J Chin Integr Med, 2007, 5(3): 263-267.  .
5Lou SY, Liu Y, Ma YY, Chen HY, Chen WH, Ying J, He YM, Wang WJ. Effects of Yiqi Sanju Formula on non-alcoholic fatty liver disease: a randomized controlled trial[J]. J Chin Integr Med, 2008, 6(8): 793-798.  .
6Wang WJ. Inspection of the relationship between disease and syndrome complex: analogous syndrome complex in the same disease[J].Zhongguo Zhong Xi Yi Jie He Za Zhi, 2011, 31(8): 1023-1024.  .
7Xue HL, Zhang Z, Wang WJ, Chen WH, Ying J. Effects of “Yiqi Zengmin Recipe” on microalbuminuria and insulin resistance of type 2 diabetic in rats[J].Zhongguo Lao Nian Xue Za Zhi, 2011, (31): 4213-4215.  .
8Joint Committee for Developing Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults. Chinese guidelines on prevention and treatment of dyslipidemia in adults[J].Zhonghua Xin Xue Guan Bing Za Zhi, 2007, 35(5): 390-419.  .
9Esteghamati A, Rashidi A, Khalilzadeh O, Ashraf H, Abbasi M. Metabolic syndrome is independently associated with microalbuminuria in type 2 diabetes[J].Acta Diabetol, 2010, 47(2): 125-130.  .
10Klausen KP, Scharling H, Jensen G, Jensen JS. New definition of microalbuminuria in hypertensive subjects: association with incident coronary heart disease and death[J].Hypertension, 2005, 46(1): 33-37.  .
11Abdul-Ghani M, Nawaf G, Nawaf F, Itzhak B, Minuchin O, Vardi P. Increased prevalence of microvascular complications in type 2 diabetes patients with the metabolic syndrome[J].Isr Med Assoc J, 2006, 8(6): 378-382.  .
12Parvanova AI, Trevisan R, Iliev IP, Dimitrov BD, Vedovato M, Tiengo A, Remuzzi G, Ruggenenti P. Insulin resistance and microalbuminuria: a cross-sectional, case-control study of 158 patients with type 2 diabetes and different degrees of urinary albumin excretion[J].Diabetes, 2006, 55(5): 1456-1462.  .
13Chan JC, Tomlinson B, Nicholls MG, Swaminathan R, Cheung CK, Woo J, Cockram CS. Albuminuria, insulin resistance and dyslipidaemia in Chinese patients with non-insulin-dependent diabetes (NIDDM)[J].Diabet Med, 1996, 13(2): 150-157.  .
14Mykk?nen L, Zaccaro DJ, Wagenknecht LE, Robbins DC, Gabriel M, Haffner SM. Microalbuminuria is associated with insulin resistance in nondiabetic subjects: the insulin resistance atherosclerosis study[J].Diabetes, 1998, 47(5): 793-800.  .
15Kurella M, Lo JC, Chertow GM. Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults[J].J Am Soc Nephrol, 2005, 16(7): 2134-2140.  .
16Adler AI, Stevens RJ, Manley SE, Bilous RW, Cull CA, Holman RR; UKPDS GROUP. Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64)[J].Kidney Int, 2003, 63(1): 225-232.  .
17Lane JT. Microalbuminuria as a marker of cardiovascular and renal risk in type 2 diabetes mellitus: a temporal perspective[J].Am J Physiol, 2004, 286(3): F442-F450.  .
18Hillege HL, Fidler V, Diercks GF, van Gilst WH, de Zeeuw D, van Veldhuisen DJ, Gans RO, Janssen WM, Grobbee DE, de Jong PE; Prevention of Renal and Vascular End Stage Disease (PREVEND) Study Group. Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population[J].Circulation, 2002, 106(14): 1777-1782.  .
19Wahba IM, Mak RH. Obesity and obesity-initiated metabolic syndrome: mechanistic links to chronic kidney disease[J].Clin J Am Soc Nephrol, 2007, 2(3): 550-562.  .
20Hernandez AV, Usmani A, Rajamanickam A, Moheet A. Thiazolidinediones and risk of heart failure in patients with or at high risk of type 2 diabetes mellitus: a meta-analysis and meta-regression analysis of placebo-controlled randomized clinical trials[J].Am J Cardiovasc Drugs, 2011, 11(2): 115-128.  .
21Wang WJ. Foundation and application of aggregation syndrome theory in traditional Chinese medicine[J]. J Chin Integr Med, 2007, 5(2): 111-114.  .
22Wang WJ. Pay more attention to “analogous syndrome complex in the same disease and treating the same disease with analogous methods”[J]. J Chin Integr Med, 2008, 6(5): 441-445.  .
23Wang SH, Wang WJ, Wang XF, Chen WH. Effect of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3 L1 adipocytes[J].Zhongguo Zhong Xi Yi Jie He Za Zhi, 2004, 24(10): 926-928.  .
24Liu Y, Lou SY, He YM, Chen WH, Ying J, Wang WJ. Effects of berberine on cell proliferation, peroxisome proliferation activated receptor gamma, CAAT/enhancer binding protein mRNA and protein expression in 3T3-L1 pre-adipocytes[J].Zhongguo Zhong Xi Yi Jie He Za Zhi, 2008, 28(11): 1005-1009.  .
25He YM, Wang WJ, Chen WH, Ying J. Effects of Pollen Typhae total flavones on mRNA expressions of peroxisome proliferator-activated receptors in 3T3-L1 adipocytes[J]. J Chin Integr Med, 2008, 6(9): 939-941.  .
26Feng XT, Wang TZ, Leng J, Chen Y, Liu JB, Liu Y, Wang WJ. Palmitate contributes to insulin resistance through downregulation of the Src-mediated phosphorylation of Akt in C2C12 myotubes[J].Biosci Biotechnol Biochem, 2012, 76(7): 1356-1361.  .
27Feng XT, Wang TZ, Chen Y, Liu JB, Liu Y, Wang WJ. Pollen Typhae total flavone improves insulin-induced glucose uptake through the beta-arrestin-2-mediated signaling in C2C12 myotubes. Int J Mol Med, 2012; 30(4): 914-922.
28Zhang Z, Xue HL, Liu Y, Wang WJ. Yi-Qi-Zeng-Min-Tang, a Chinese medicine, ameliorates insulin resistance in type 2 diabetic rats[J].World J Gastroenterol, 2011, 17(8): 987-995.  .

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