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Journal of Chinese Integrative Medicine: 2005; 3(5): 374-377
DOI: 10.3736/jcim20050511
Effects of Lycium barbarum polysaccharide on tumor microenvironment T-lymphocyte subsets and dendritic cells in H22-bearing mice
1. HE Yan-Li (Department of Pathology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province 510405, China E-mail: Yanlihe16@163.com)
2. YING Yi (Department of Hematology, Guangzhou Municipal First People's Hospital, Guangzhou, Guangdong Province 510180, China )
3. XU Yan-Li (Department of Hematology, Guangzhou Municipal First People's Hospital, Guangzhou, Guangdong Province 510180, China )
4. SU Jun-Fang (Department of Pathology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province 510405, China )
5. LUO Hui (Department of Pathology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province 510405, China )
6. WANG Hui-Feng (Department of Pathology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province 510405, China )

Objective: To study the effects of Lycium barbarum polysaccharide (LBP) on tumor microenvironment T-lymphocyte subsets and dendritic cells in H22-bearing mice and the mechanisms for intervention of tumor immune escape by LBP.

Methods: H22-bearing mice were given LBP orally for two weeks. T-lymphocyte subsets and the phenotypes of dendritic cells in tumor-infiltrating lymphocytes (TIL) were detected by flow cytometry (FCM).

Results: LBP could significantly increase the numbers of CD4+ and CD8+ T cells in TIL as compared with those in model control group (P<0.05). In model control group, the number of dendritic cells in tumor microenvironment decreased markedly, while in LBP-treated group, the increased number of dendritic cells and B7-1 expression were observed, but there were no significant differences between these two groups.

Conclusion: LBP has anti-tumor effect probably by increasing the numbers of CD4+ and CD8+ T cells in TIL to relieve the immunosuppression and enhance the anti-tumor function of the immune system. But whether LBP can recover the phenocyte and function of dendritic cells in H22-bearing mice should be further studied.

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Please cite this article as:
He YL, Ying Y, Xu YL, Su JF, Luo H, Wang HF. Effects of Lycium barbarum polysaccharide on tumor microenvironment T-lymphocyte subsets and dendritic cells in H22-bearing mice. J Chin Integr Med / Zhong Xi Yi Jie He Xue Bao. 2005; 3(5): 374-377.
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