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Journal of Chinese Integrative Medicine: 2013; 11(1): 2-10
DOI: 10.3736/jintegrmed2013002
Differential effects of adulterated versus unadulterated forms of linoleic acid on cardiovascular health
1. Stephen D. Anton (Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida 32611, USA E-mail: santon@ufl.edu)
2. Kacey Heekin (Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida 32611, USA )
3. Carrah Simkins (Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida 32611, USA )
4. Andres Acosta (Department of Medicine, University of Florida, Gainesville, Florida 32611, USA )

ABSTRACT: According to the classic “diet-heart” hypothesis, high dietary intake of saturated fats and cholesterol combined with low intake of polyunsaturated fats can increase levels of serum cholesterol and lead to the development of atherogenic plaques and ultimately cardiovascular diseases. Recently, the beneficial health effects of omega-6 polyunsaturated fatty acids, particularly linoleic acid (LA), on cardiovascular health have been called into question with some scientists suggesting that consumption of LA should be reduced in Western countries. The focus of this critical review is on the controversy surrounding the effects of dietary intake of LA on cardiovascular health. Specifically, we critically examined the effects of both unadulterated and adulterated forms of LA on cardiovascular health outcomes based on findings from epidemiological studies and randomized controlled trials. Additionally, we address common concerns surrounding dietary intake of LA regarding its relationship with arachidonic acid, the ratio of omega-6 to omega-3 fatty acids, and its relationship with inflammation. Our critical review indicates that unadulterated forms of LA are cardioprotective and should be consumed as part of a healthy diet. In contrast, abundant evidence now indicates that adulterated forms of LA, predominantly hydrogenated vegetable oils, are atherogenic and should not be considered part of a healthy diet. The ability to adulterate the natural omega-6 fatty acid, LA, has contributed to mixed findings regarding the effects of this fatty acid on cardiovascular health. Thus, it is critical that the source of LA be taken into account when drawing conclusions about the physiological effects of this fatty acid. The findings of the present review are in line with current dietary recommendations of the American Heart Association.

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Please cite this article as:
Stephen D. Anton, Kacey Heekin, Carrah Simkins, Andres Acosta. Differential effects of adulterated versus unadulterated forms of linoleic acid on cardiovascular health. J Integr Med. 2013; 11(1): 2-10.
References:
1Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Ferguson TB, Ford E, Furie K, Gillespie C, Go A, Greenlund K, Haase N, Hailpern S, Ho PM, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott MM, Meigs J, Mozaffarian D, Mussolino M, Nichol G, Roger VL, Rosamond W, Sacco R, Sorlie P, Stafford R, Thom T, Wasserthiel-Smoller S, Wong ND, Wylie-Rosett J; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Executive summary: heart disease and stroke statistics — 2010 update: a report from the American Heart Association[J].Circulation, 2010, 121(7): 948-954.  .
2Mensah GA, Ryan US, Hooper WC, Engelgau MM, Callow AD, Kapuku GK, Mantovani A. Vascular endothelium summary statementⅡ: Cardiovascular disease prevention and control[J].Vascul Pharmacol, 2007, 46(5): 318-320.  .
3Stampfer MJ, Hu FB, Manson JE, Rimm EB, Willett WC. Primary prevention of coronary heart disease in women through diet and lifestyle[J].N Engl J Med, 2000, 343(1): 16-22.  .
4Asp ML, Collene AL, Norris LE, Cole RM, Stout MB, Tang SY, Hsu JC, Belury MA. Time-dependent effects of safflower oil to improve glycemia, inflammation and blood lipids in obese, post-menopausal women with type 2 diabetes: a randomized, double-masked, crossover study[J].Clin Nutr, 2011, 30(4): 443-449.  .
5Becker N, Illingworth DR, Alaupovic P, Connor WE, Sundberg EE. Effects of saturated, monounsaturated, and ω-6 polyunsaturated fatty acids on plasma lipids, lipoproteins, and apoproteins in humans[J].Am J Clin Nutr, 1983, 37(3): 355-360.  .
6Derr J, Kris-Etherton PM, Pearson TA, Seligson FH. The role of fatty acid saturation on plasma lipids, lipoproteins, and apolipoproteins: Ⅱ. The plasma total and low-density lipoprotein cholesterol response of individual fatty acids[J].Metabolism, 1993, 42(1): 130-134.  .
7Hunter KA, Crosbie LC, Weir A, Miller GJ, Dutta-Roy AK. A residential study comparing the effects of diets rich in stearic acid, oleic acid, and linoleic acid on fasting blood lipids, hemostatic variables and platelets in young healthy men[J].J Nutr Biochem, 2000, 11(7-8): 408-416.  .
8Hunter KA, Crosbie LC, Horgan GW, Miller GJ, Dutta-Roy AK. Effect of diets rich in oleic acid, stearic acid and linoleic acid on postprandial haemostatic factors in young healthy men[J].Br J Nutr, 2001, 86(2): 207-215.  .
9Kris-Etherton PM, Derr J, Mitchell DC, Mustad VA, Russell ME, McDonnell ET, Salabsky D, Pearson TA. The role of fatty acid saturation on plasma lipids, lipoproteins, and apolipoproteins:Ⅰ. Effects of whole food diets high in cocoa butter, olive oil, soybean oil, dairy butter, and milk chocolate on the plasma lipids of young men[J].Metabolism, 1993, 42(1): 121-129.  .
10Mensink RP, Zock PL, Katan MB, Hornstra G. Effect of dietary cis and trans fatty acids on serum lipoprotein[a] levels in humans[J].J Lipid Res, 1992, 33(10): 1493-1501.  .
11Thijssen MA, Mensink RP. Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans[J].Am J Clin Nutr, 2005, 82(3): 510-516.  .
12Thijssen MA, Hornstra G, Mensink RP. Stearic, oleic, and linoleic acids have comparable effects on markers of thrombotic tendency in healthy human subjects[J].J Nutr, 2005, 135(12): 2805-2811.  .
13Vega-López S, Matthan NR, Ausman LM, Ai M, Otokozawa S, Schaefer EJ, Lichtenstein AH. Substitution of vegetable oil for a partially-hydrogenated fat favorably alters cardiovascular disease risk factors in moderately hypercholesterolemic postmenopausal women[J].Atherosclerosis, 2009, 207(1): 208-212.  .
14Zock PL, Katan MB. Hydrogenation alternatives: effects of trans fatty acids and stearic acid versus linoleic acid on serum lipids and lipoproteins in humans[J].J Lipid Res, 1992, 33(3): 399-410.  .
15Willett WC. Dietary fats and coronary heart disease[J].J Intern Med, 2012, 272(1): 13-24.  .
16Whelan J. The health implications of changing linoleic acid intakes[J].Prostaglandins Leukot Essent Fatty Acids, 2008, 79(3-5): 165-167.  .
17Ramsden CE, Hibbeln JR, Majchrzak-Hong SF. All PUFAs are not created equal: absence of CHD benefit specific to linoleic acid in randomized controlled trials and prospective observational cohorts[J].World Rev Nutr Diet, 2011, 102: 30-43.  .
18Doell D, Folmer D, Lee H, Honigfort M, Carberry S. Updated estimate of trans fat intake by the US population[J].Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2012, 29(6): 861-874.  .
19Mozaffarian D, Micha R, Wallace S. Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials[J].PLoS Med, 2010, 7(3): e1000252.  .
20Czernichow S, Thomas D, Bruckert E. n-6 Fatty acids and cardiovascular health: a review of the evidence for dietary intake recommendations[J].Br J Nutr, 2010, 104(6): 788-796.  .
21Harris WS, Mozaffarian D, Rimm E, Kris-Etherton P, Rudel LL, Appel LJ, Engler MM, Engler MB, Sacks F. Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention[J].Circulation, 2009, 119(6): 902-907.  .
22Laaksonen DE, Nyyss?nen K, Niskanen L, Rissanen TH, Salonen JT. Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids[J].Arch Intern Med, 2005, 165(2): 193-199.  .
23Warensj? E, Sundstr?m J, Vessby B, Cederholm T, Risérus U. Markers of dietary fat quality and fatty acid desaturation as predictors of total and cardiovascular mortality: a population-based prospective study[J].Am J Clin Nutr, 2008, 88(1): 203-209.  .
24Wolfe MS, Sawyer JK, Morgan TM, Bullock BC, Rudel LL. Dietary polyunsaturated fat decreases coronary artery atherosclerosis in a pediatric-aged population of African green monkeys[J].Arterioscler Thromb, 1994, 14(4): 587-597.  .
25Mozaffarian D, Abdollahi M, Campos H, Houshiarrad A, Willett WC. Consumption of trans fats and estimated effects on coronary heart disease in Iran[J].Eur J Clin Nutr, 2007, 61(8): 1004-1010.  .
26Lemaitre RN, King IB, Mozaffarian D, Sotoodehnia N, Rea TD, Kuller LH, Tracy RP, Siscovick DS. Plasma phospholipid trans fatty acids, fatal ischemic heart disease, and sudden cardiac death in older adults: the cardiovascular health study[J].Circulation, 2006, 114(3): 209-215.  .
27Matthan NR, Welty FK, Barrett PH, Harausz C, Dolnikowski GG, Parks JS, Eckel RH, Schaefer EJ, Lichtenstein AH. Dietary hydrogenated fat increases high-density lipoprotein apoA-Ⅰ catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women[J].Arterioscler Thromb Vasc Biol, 2004, 24(6): 1092-1097.  .
28Mauger JF, Lichtenstein AH, Ausman LM, Jalbert SM, Jauhiainen M, Ehnholm C, Lamarche B. Effect of different forms of dietary hydrogenated fats on LDL particle size[J].Am J Clin Nutr, 2003, 78(3): 370-375.  .
29Vega-López S, Ausman LM, Jalbert SM, Erkkil? AT, Lichtenstein AH. Palm and partially hydrogenated soybean oils adversely alter lipoprotein profiles compared with soybean and canola oils in moderately hyperlipidemic subjects[J].Am J Clin Nutr, 2006, 84(1): 54-62.  .
30Lemaitre RN, King IB, Raghunathan TE, Pearce RM, Weinmann S, Knopp RH, Copass MK, Cobb LA, Siscovick DS. Cell membrane trans-fatty acids and the risk of primary cardiac arrest[J].Circulation, 2002, 105(6): 697-701.  .
31Frantz ID Jr, Dawson EA, Ashman PL, Gatewood LC, Bartsch GE, Kuba K, Brewer ER. Test of effect of lipid lowering by diet on cardiovascular risk. The Minnesota Coronary Survey[J].Arteriosclerosis, 1989, 9(1): 129-135.  .
32Woodhill JM, Palmer AJ, Leelarthaepin B, McGilchrist C, Blacket RB. Low fat, low cholesterol diet in secondary prevention of coronary heart disease[J].Adv Exp Med Biol, 1978, 109: 317-330.  .
33Rett BS, Whelan J. Increasing dietary linoleic acid does not increase tissue arachidonic acid content in adults consuming Western-type diets: a systematic review[J].Nutr Metab (Lond), 2011, 8: 36.  .
34Liou YA, King DJ, Zibrik D, Innis SM. Decreasing linoleic acid with constant α-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men[J].J Nutr, 2007, 137(4): 945-952.  .
35Lands WE. Biochemistry and physiology of n-3 fatty acids[J].FASEB J, 1992, 6(8): 2530-2536.  .
36Simopoulos AP. The importance of the ratio of ω-6/ω-3 essential fatty acids[J].Biomed Pharmacother, 2002, 56(8): 365-379.  .
37Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Willett WC, Rimm EB. Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women[J].Circulation, 2003, 108(2): 155-160.  .
38Khaw KT, Friesen MD, Riboli E, Luben R, Wareham N. Plasma phospholipid fatty acid concentration and incident coronary heart disease in men and women: the EPIC-Norfolk prospective study[J].PLoS Med, 2012, 9: e1001255.  .
39Ferrucci L, Cherubini A, Bandinelli S, Bartali B, Corsi A, Lauretani F, Martin A, Andres-Lacueva C, Senin U, Guralnik JM. Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers[J].J Clin Endocrinol Metab, 2006, 91(2): 439-446.  .
40Petersson H, Basu S, Cederholm T, Risérus U. Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation: longitudinal analyses in middle-aged men[J].Br J Nutr, 2008, 99(6): 1186-1189.  .
41Bjermo H, Iggman D, Kullberg J, Dahlman I, Johansson L, Persson L, Berglund J, Pulkki K, Basu S, Uusitupa M, Rudling M, Arner P, Cederholm T, Ahlstr?m H, Risérus U. Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial[J].Am J Clin Nutr, 2012, 95(5): 1003-1012.  .

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