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Journal of Chinese Integrative Medicine: 2003; 1(4): 296-300
DOI: 10.3736/jcim20030421
Medical value of isoflavones
1. DU Ning (Department of Traumatology, Ruijin Hospital, Shanghai Second Medical University, Shanghai Institute of Traumatology and Orthopedics, Shanghai 200025, China E-mail: duning@vip.163.com)
2. XU Yong (Department of Traumatology, Ruijin Hospital, Shanghai Second Medical University, Shanghai Institute of Traumatology and Orthopedics, Shanghai 200025, China )

ABSTRACT: Isoflavones as a kind of phytoestrogen exist in soy plant widely. With the advantages of estrogen, they can regulate endocrine function of the human body, reduce blood cholesterol, decrease the incidence of coronary heart disease, prevent osteoporosis, inhibit tumor growth, and relieve pain. This article summarized the investigations on the medical value of isoflavones in recent years.

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Please cite this article as:
Du N, Xu Y. Medical value of isoflavones. J Chin Integr Med / Zhong Xi Yi Jie He Xue Bao. 2003; 1(4): 296-300.
References:
1Adlercreutz H, Mazur W. Phyto-oestrogens and Western diseases[J].Ann Med, 1997, 29(2): 95-120.  .
2Anthony MS, Clarkson TB, Bullock BC, et al. Soy protein versus soy phytoestrogens in the prevention of diet-induced coronary artery atherosclerosis of male cynomolgus monkeys[J].Arterioscler Thromb Vasc Biol, 1997, 17(11): 2524-2531.  .
3Crouse JR III, Terry JG, Morgan TM, et al. Soy protein containing isoflavones reduces plasma concentrations of lipids and lipoproteins[J].Circulation, 1998, 97: 816.  .
4Potter SM, Baum JA, Teng H, et al. Soy protein and isoflavones:their effects on blood lipids and bone density in postmenopausal women[J].Am J Clin Nutr, 1998, 68(6 suppl): 1375S-1379S.  .
5Anthony MS, Clarkson TB. Comparison of soy phytoestrogens and conjugated equine estrogens on atherosclerosis progression in postmenopausal monkeys[J].Circulation, 1998, 97: 829.  .
6Tikkanen MJ, Wahala K, Ojala S, et al. Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance[J].Proc Natl Acad Sci USA, 1998, 95(6): 3106-3110.  .
7Makela S, Savolainen H, Aavik E, et al. Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to estrogen receptors alpha and beta[J].Proc Natl Acad Sci USA, 1999, 96(12): 7077-7082.  .
8Nakashima S, Koike T, Nozawa Y. Genistein, a protein tyrosine kinase inhibitor,inhibits thromboxane A2-mediated human platelet responses[J].Mol Pharmacol, 1991, 39(4): 475-480.  .
9Schoene NW, Guidry CA. Dietary soy isoflavones inhibit activation of rat platelets[J].J Nutr Biochem, 1999, 10: 421-426.  .
10Nestel PJ, Yamashita T, Sasahara T, et al. Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women[J].Arterioscler Thromb Vasc Biol, 1997, 17(12): 3392-3398.  .
11Washburn S, Burke GL, Morgan T, et al. Effect of soy protein supplementation on serum lipoproteins,blood pressure,and menopausal symptoms in perimenopausal women[J].Menopause, 1999, 6(1): 7-13.  .
12West SG, Stoney Ca M, Habash D L, et al. Soy supplements with phytoestrogens reduce blood pressure at rest and during stress in middle-aged men[A]. The fourth international symposium the role of soy in preventing and treating chronic disease[C]. San Diego, CA, November 4-7, 2001.
13Yoon HK, Chen K, Baylink DJ, et al. Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein,on human bone cell proliferation as compared with differentiation[J].Calcif Tissue Int, 1998, 63(3): 243-249.  .
14Chen XW, Garner SC, Anderson JJ. Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway[J].Biochem Biophys Res Commun, 2002, 295(2): 417-422.  .
15Gao YH, Yamaguchi M. Inhibitory effect of genistein on osteoclast-like cell formation in mouse marrow cultures[J].Biochem Pharmacol, 1999, 58(5): 767-772.  .
16Rassi CM, Lieberherr M, Chaumaz G, et al. Down-regulation of osteoclast differentiation by daidzein via caspase 3[J].J Bone Miner Res, 2002, 17(4): 630-638.  .
17Kajiya H, Okabe K, Okamoto F, et al. Protein tyrosine kinase inhibitors increase cytosolic calcium and inhibit actin organization as resorbing activity in rat osteoclasts[J].J Cell Physiol, 2000, 183(1): 83-90.  .
18Gao YH, Yamaguchi M. Suppressive effect of genistein on rat bone osteoclasts: apoptosis is induced through Ca2+ signaling[J].Biol Pharm Bull, 1999, 22(8): 805-809.  .
19Anderson JJ, Ambrose WW. Orally dosed genistein from soy and prevention of cancellous bone loss in two ovariectomized rat models[J].J Nutr, 1995, 125(suppl): 783-799.  .
20Arjmandi BH, Alekel L, Hollis BW, et al. Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis[J].J Nutr, 1996, 126(1): 161-167.  .
21Arjmandi BH, Birnbaum R, Goyal NV, et al. Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content[J].Am J Clin Nutr, 1998, 68(6 suppl): 1364s-1368s.  .
22Ishida H, Uesugi T, Hirai K, et al. Preventive effects of the plant isoflavone,daidzein and genistein,on bone loss in ovariectomized rats fed a calcium-deficient diet[J].Biol Pharm Bull, 1998, 21(1): 62-66.  .
23Fanti O, Faugere MC, Gang Z, et al. Systemic administration of genistein partially prevents bone loss in ovariectomized rats in a nonestrogen-like mechanism[J].Am Nutr, 1998, 68(suppl): 1517-1522.  .
24Alekel DL, Germain AS, Peterson CT, et al. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women[J].Am J Clin Nutr, 2000, 72(3): 844-852.  .
25Olsen E L, Jensen JE, Kenneth DR, et al. Isoflavone-rich soymilk prevents bone loss in the lumbar spine of postmenopausal Women. A 2-y Study[A]. The fourth international symposium the role of soy in preventing and treating chronic disease[C]. San Diego, CA, November 4-7, 2001.
26Mei J, Yeung SS, Kung AW. High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women[J].J Clin Endocrinol Metab, 2001, 86(11): 5217-5221.  .
27Tang GWK. The climacteric of Chinese factory workers[J].Maturitas, 1994, 19(13): 177-182.  .
28Albertazzi P, Pansini F, Bonaccorsi G, et al. The effect of dietary soy supplementation on hot flushes[J].Obstet Gynecol, 1998, 91(1): 6-11.  .
29Upmalis D, Lobo R, Bradley L. Evaluation of the safety and efficacy of an oral soy extract in the treatment of vasomotor symptoms in menopausal women[J].Menopause, 1999, 6(-): 327.  .
30Dalais FS, Rice GE, Wahlqvist ML, et al. Effects of dietary phytoestrogens in postmenopausal women[J].Climacteric, 1998, 1(2): 124-129.  .
31Kolonel LN. Variability in diet and its relation to risk in ethnic and migrant groups[J].Basic Life Sci, 1988, 43(-): 129-135.  .
32Akiyama T, Ishida J, Nakagawa S, et al. Genistein,a specific inhibitor of tyrosine specific protein kinases[J].J Biol Chem, 1987, 262(12): 5592-5595.  .
33Lamartiniere CA, Murrill WB, Manzolillo PA, et al. Genistein alters the ontogeny of mammary gland development and protects against mammary cancer in rats[J].Proc Soc Exp Biol Med, 1997, 217(-): 358-364.  .
34Wei H, Wei L, Frankel K, et al. Inhibition of tumor promoter induced hydrogen peroxide formation in vitro and in vivo by genistein[J].Nutr Cancer, 1993, 20(1): 1-12.  .
35Fotsis T, Pepper M, Adlercreutz H, et al. Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis[J].J Nutr, 1995, 125(3 suppl): 790S-797S.  .
36Terson TG, Kim H, Barnes S. Genistein may inhibit the growth of human mammary epithelial (HME) cells by augmenting transforming growth factor beta (TGFb) signaling[J].Am J Clin Nutr, 1998, 68(suppl): 1527S (abstr).  .
37Lee HP, Gourley L, Duffy SW, et al. Dietary effects on breast cancer risk in Singapore[J].Lancet, 1991, 337(8751): 1197-1200.  .
38Peterson G, Barnes S. Genistein inhibition of the growth of human breast cancer cells independence from estrogen receptors and the multi-drug resistance gene[J].Biochem Biophys Res Commun, 1991, 179(1): 661-667.  .
39Zava DT, Duwe G. Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro[J].Nutr Cancer, 1997, 27(1): 31-40.  .
40Lamartiniere CA. Protection against breast cancer with genistein:a component of soy[J].Am J Clin Nutr, 2000, 71(6 suppl): 1705s-1707s.  .
41Peterson G, Barnes S. Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation[J].Prostate, 1993, 22(4): 335-345.  .
42Morton MS, Chan PS, Cheng C, et al. Lignans and isoflavonoids in plasma and prostatic fluid in men: samples from Portugal, Hong Kong, and the United Kingdom[J].Prostate, 1997, 32(2): 122-128.  .
43Schleicher RL, Lamartiniere CA, Zheng M, et al. The inhibitory effect of genistein on the growth and metastasis of a transplantable rat accessory sex gland carcinoma[J].Cancer Lett, 1999, 136(2): 195-201.  .
44Onozawa M, Kawamori T, Baba M, et al. Effects of a soybean isoflavone mixture on carcinogenesis in prostate and seminal vesicles of F344 rats[J].Jpn J Cancer Res, 1999, 90(4): 393-398.  .
45Mentor-Marcel R, Lamartiniere CA, Elgavish A. Mechanisms by which genistein may prevent prostate cancer in a transgenic mouse model[A]. In: Proceedings of the international conference on prostate cancer research[C]. Iowa City, IA, 1999.
46Rosenberg ZRS, Jenkins DJ, Brown TJ, et al. Flavonoids can block PSA production by breast and prostate cancer cell lines[J].Clin Chim Acta, 2002, 317(1-2): 17-26.  .
47Sadowska-Krowicka H, Mannick EE, Oliver PD, et al. Genistein and gut inflammation: role of nitric oxide[J].Proc Soc Exp Biol Med, 1998, 217(3): 351-357.  .
48Rice MM, LaCroix AZ, Lampe JW, et al. Dietary soy isoflavone intake, postmenopausal estrogen use,and self-reported arthritis in older Japanese American women[A]. The fourth international symposium the role of soy in preventing and treating chronic disease[C], San Diego, CA, November 4-7, 2001.
49Gabor M, Razga Z. Effect of benzopyrone derivatives on simultaneously induced croton oil ear oedema and carrageenin paw oedema in rats[J].Acta Physiol Hung, 1991, 77(3-4): 197-207.  .
50Kalashnikova NA, Baturo AP, Locosova AK, et al. Enzyme characteristics of bacteria of the genera Citrobacter and Hafnia and their identification during laboratory diagnosis of intestinal infections[J].Zh Mikrobiol Epidemiol Immunobiol, 1974, (2): 106-109.  .
51Min B, Oh SR, Lee HK, et al. Sophoricoside analogs as the IL-5 inhibitors from Sophora japonica[J].Planta Med, 1999, 65(5): 408-412.  .
52Kim H, Xia H, Li L, et al. Attenuation of neurodegeneration-relevant modifications of brain proteins by dietary soy[J].Biofactors, 2000, 12(1-4): 243-250.  .
53File SE, Jarrett N, Fluck E, et al. Eating soya improves human memory[J].Psychopharmacology (Berl), 2001, 157(4): 430-436.  .
54Cai Q, Wei H. Effect of dietary genistein on antioxidant enzyme activities in SENCAR mice[J].Nutr Cancer, 1996, 25(1): 1-7.  .
55Wei H. Photoprotective action of isoflavone genistein: models mechanisms, and relevance to clinical dermatology[J].J Am Acad Dermatol, 1998, 39(2, pt1): 271-272.  .
56Strom BL, Schinnar R, Ziegler E, et al. Exposure to soy-based formula in infancy and endocrinological and reproductive outcomes in young adulthood[J].JAMA, 2001, 286(5): 807-814.  .
57Kurzer MS. Hormonal effects of soy in premenopausal women and men[J].J Nutr, 2002, 132(3): 570S-573S.  .
58Foth D, Cline JM. Effects of mammalian and plant estrogens on mammary glands and uteri of macaques[J].Am J Clin Nutr, 1998, 68(6 Suppl): 1413S-1417S.  .
59Chang HC, Doerge DR. Dietary genistein inactivates rat thyroid peroxidase in vivo without an apparent hypothyroid effect[J].Toxicol Appl Pharmacol, 2000, 168(3): 244-252.  .
60Yellayi S, Naaz A, Szewczykowski MA, et al. The phytoestrogen genistein induces thymic and immune changes: a human health concern[J].Proc Natl Acad Sci USA, 2002, 99(11): 7616-7621.  .

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