Updated Friday, March 22, 2019
Open Access
-  Abstract
-  Full text
-  Download PDF file
-  Send to a friend
-  Related articles in JCIM & JIM
-  Cited in JCIM & JIM
-  Reader's comments
-  Send a comment
 Language Polishing
Review Article
Journal of Chinese Integrative Medicine: Volume 8, 2010   Issue 11
A mechanism of endogenous opioid peptides for rapid onset of acupuncture effect in treatment of depression
1. Xin-jun Wang (Laboratory of Integrated Acupuncture and Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China )
2. Ling-ling Wang (Laboratory of Integrated Acupuncture and Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China E-mail: wangllbox@hotmail.com)

Abstract: Clinical and experimental studies show that the onset of effect of acupuncture on depression is more rapid than selective serotonin reuptake inhibitors, a class of antidepressants. Acupuncture treatment is characterized by controlling anxiety and gastrointestinal discomfort. The onset time of acupuncture treatment for various pains is a week or so, which is the same as the rapid onset time of antidepressant effect of acupuncture, and the main pathway of acupuncture analgesia is through endogenous opioid system. Opioid peptides can produce pleasure, and decrease anxiety and gastrointestinal discomfort, so opioid peptides are considered to have antidepressant effect. Accordingly, the main pathway of acupuncture analgesia — the endogenous opioid system, is considered a mechanism for rapid onset of acupuncture effects on depression.


Wang XJ, Wang LL. J Chin Integr Med. 2010; 8(11): 1014-1017. Received April 15, 2010; accepted June 2, 2010; published online November 15, 2010. Indexed/abstracted in and full-text link-out at PubMed. Journal title in PubMed: Zhong Xi Yi Jie He Xue Bao. Free full text (HTML and PDF) is available at http://www.jcimjournal.com. Forward linking and reference linking via CrossRef. DOI: 10.3736/jcim20101102


Correspondence: Ling-ling Wang, MD, Professor; Tel: 025-86798095; E-mail: wangllbox@hotmail.com


Full text of this article is in Chinese

1. Li SR, Shen YD, Zhang WX, Chen CH, Huang YQ, Wang DP, Wang JR, Tu J, Ning ZX, Fu LM, Ji LP, Liu ZG, Wu HM, Luo KL, Zhai ST, Yan H, Meng GR. Epidemiological survey on mental disorders in 7 areas of China[J]. Zhonghua Shen Jing Ke Za Zhi, 1998, 31(2) : 80. Chinese.
2. Cao XM, Yang ZX, Xie HL, Zhang Y, Zhang JC, Rao XD. Randomized control study on depression induced by chronic pain treated with acupuncture[J]. World J Acu-moxi, 2007, 17(3) : 1-8.
3. Wang XJ, Wang LL, Qiao HF, Li JB. Acupuncture combined with herbal medicine in treatment of 50 cases of depression[J]. Jiangsu Zhong Yi Yao, 2008, 40(12) : 74-76. Chinese.
4. Wang XJ, Wang LL, Qiao HF, Li JB. Observing clinical efficacy and characteristics of acupuncture and medicine in treating depression sleep disorders[J]. Zhen Jiu Lin Chuang Za Zhi, 2008, 24(12) : 1-2. Chinese with abstract in English.
5. Zhang JB, Wang LL, Lu M, Liu LY, Li D. Effects of acupuncture at different acupoints on behaviors in depression model rats[J]. Zhongguo Zhen Jiu, 2005, 25(9) : 639-643. Chinese with abstract in English.
6. Liu LY, Wang LL, Lu M, Li D. Efficacy of electro-acupuncture combined with SSRI drugs on HAMD score in depression[J]. Sichuan Zhong Yi, 2005, 23(7) : 96-98. Chinese.
7. Darko DF, Risch SC, Gillin JC, Golshan S. Association of beta-endorphin with specific clinical symptoms of depression[J]. Am J Psychiatry, 1992, 149(9) : 1162-1167.
8. Sheline YI. 3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity[J]. Biol Psychiatry, 2000, 48(8) : 791-800.
9. Hung K, Wu H, Mizoguchi H, Leitermann R, Tseng LF. Intrathecal treatment with 6-hydroxydopamine or 5,7-dihydroxytryptamine blocks the antinociception induced by endomorphin-1 and endomorphin-2 given intracerebroventricularly in the mouse[J]. J Pharmacol Sci, 2003, 93(3) : 299-306.
10. Huang EY, Chen CM, Tao PL. Supraspinal anti-allodynic and rewarding effects of endomorphins in rats[J]. Peptides, 2004, 25(4) : 577-583.
11. Zhang H, Torregrossa MM, Jutkiewicz EM, Shi YG, Rice KC, Woods JH, Watson SJ, Holden Ko MC. Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through δ- and μ-opioid receptors independent of antidepressant-like effects[J]. Eur J Neurosci, 2006, 23(4) : 984-994.
12. Fichna J, Janecka A, Piestrzeniewicz M, Costentin J, do Rego JC. Antidepressant-like effect of endomorphin-1 and endomorphin-2 in mice[J]. Neuropsychopharmacology, 2007, 32(4) : 813-821.
13. Cryan JF, Mombereau C, Vassout A. The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice[J]. Neurosci Biobehav Rev, 2005, 29(4-5) : 571-625.
14. Petit-Demouliere B, Chenu F, Bourin M. Forced swimming test in mice: a review of antidepressant activity[J]. Psychopharmacology (Berl), 2005, 177(3) : 245-255.
15. Fichna J, do-Rego JC, Kosson P, Costentin J, Janecka A. Characterization of antinociceptive activity of novel endomorphin-2 and morphiceptin analogs modified in the third position[J]. Biochem Pharmacol, 2005, 69(1) : 179-185.
16. Filliol D, Ghozland S, Chluba J, Martin M, Matthes HW, Simonin F, Befort K, Gavériaux-Ruff C, Dierich A, LeMeur M, Valverde O, Maldonado R, Kieffer BL. Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses[J]. Nat Genet, 2000, 25(2) : 195-200.
17. Li ZR. Experimental acupuncture[M]. 2nd ed. Beijing: China Press of Traditional Chinese Medicine, 2007. 137. Chinese.
Reader's comments
1. christian louboutin outlet store christian louboutin canada outlet http://canadachristianlouboutin.blogspot.com/ (2016-1-27 0:00:00)
2. louboutin canada buy christian louboutin shoes canada http://christianlouboutincanadaoutlet.blogspot.com/ (2016-1-27 0:00:00)
3. christian louboutin prices christian louboutin canada stores http://canadachristianlouboutin.blogspot.com/ (2016-1-27 0:00:00)
4. louboutin world christian louboutin sale clearance http://canadachristianlouboutinoutlet.blogspot.com/ (2016-2-24 0:00:00)

Send a comment

 Home | Current Issue | Past Issues | SearchRSS
Copyright © 2013-2018 by JIM Editorial Office. All rights reserved. ISSN 2095-4964; CN 31-2083/R. 沪ICP备110264号