Updated Tuesday, September 26, 2017
JCIM & JIM
Open Access
THIS ARTICLE
-  Abstract
-  Full text
-  Download PDF file
-  Send to a friend
-  Related articles in JCIM & JIM
-  Cited in JCIM & JIM
-  Reader's comments
-  Send a comment
 Language Polishing
Review Article
Journal of Chinese Integrative Medicine: Volume 9, 2011   Issue 7
Quality and validity of randomized controlled trials in China from the perspective of systematic reviews
1. Hui Luo (Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China )
2. Jian-ping Liu (Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China E-mail: jianping_l@hotmail.com)

Abtract: A systematic review is based on randomized controlled trials (RCTs), and the reliability of its conclusion is closely related to the quality of original literature. The low quality of existing RCTs in China leads to the failure of conclusive findings in systematic reviews when evaluating the effectiveness of interventions. It is almost universal for systematic reviews to draw the conclusion that “further well-designed multicenter and large-scale RCTs are still required to confirm the beneficial effects of interventions”. This paper analyzed the current status of RCTs in China, discussed the influence of including trials of low quality in a systematic review and assessed how a systematic review should be carried out under such circumstances. Furthermore, the methods to evaluate the quality of RCTs were introduced and evaluated. Finally, several strategies were proposed to improve the quality of RCTs in China: foster an honest academic and social environment, enhance the training of doctors on clinical research methodology, promote the implementation of clinical registration systems and strengthen the quality control of clinical research and the medical journals regulations on the quality of submitted papers.
    

Received April 9, 2011; accepted May 4, 2011; published online July 15, 2011.
Full-text LinkOut at PubMed. Journal title in PubMed: Zhong Xi Yi Jie He Xue Bao.
    
Correspondence: Jian-ping Liu, MD, Professor; Tel: 010-64286760; E-mail: jianping_l@hotmail.com

 

Full text of this article is in Chinese

  
References
1. Jiang M, Yang J, Zhang C, Liu B, Chan K, Cao H, Lu A. Clinical studies with traditional Chinese medicine in the past decade and future research and development[J]. Planta Med, 2010, 76(17) : 2048-2064.
  
2. Yao XJ, Liu CX. Bisphosphonates for multiple myeloma: a systematic review[J]. Zhongguo Xun Zheng Yi Xue Za Zhi, 2010, 10(10) : 1188-1193. Chinese with abstract in English.
  
3. Begg C, Cho M, Eastwood S, Horton R, Moher D, Olkin I, Pitkin R, Rennie D, Schulz KF, Simel D, Stroup DF. Improving the quality of reporting of randomized controlled trials. The CONSORT statement[J]. JAMA, 1996, 276(8) : 637-639.
  
4. Moher D, Jones A, Lepage L; CONSORT Group (Consolitdated Standards for Reporting of Trials). Use of the CONSORT statement and quality of reports of randomized trials: a comparative before-and-after evaluation[J]. JAMA, 2001, 285(15) : 1992-1995.
  
5. Moher D, Jones A, Lepage L; CONSORT Group (Consolitdated Standards for Reporting of Trials). The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials[J]. JAMA, 2001, 285(15) : 1987-1991.
  
6. Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, Elbourne D, Egger M, Altman DG. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials (Chinese version)[J] J Chin Integr Med, 2010, 8(8) : 701-741. Chinese with abstract in English.
7. Plint AC, Moher D, Morrison A, Schulz K, Altman DG, Hill C, Gaboury I. Does the CONSORT checklist improve the quality of reports of randomised controlled trials? A systematic review[J]. Med J Aust, 2006, 185(5) : 263-267.
  
8. Zhang D, Yin P, Freemantle N, Jordan R, Zhong N, Cheng KK. An assessment of the quality of randomised controlled trials conducted in China[J]. Trials, 2008, 9: 22-29.
  
9. Wu T, Li Y, Bian Z, Liu G, Moher D. Randomized trials published in some Chinese journals: how many are randomized?[J]. Trials, 2009, 10(46) : 46.
  
10. van Dalen EC, Kremer LCM, Moyer VA. Tips and tricks for understanding and using SR results — no. 8: quality of studies included in a systematic review and associated risk of bias — ‘garbage in, garbage out’[J]. Evid Based Child Health, 2007, 2(4) : 1321-1324.
[Wiley]  
11. Egger M, Smith GD, Sterne JA. Uses and abuses of meta-analysis[J]. Clin Med, 2001, 1(6) : 478-484.
  
12. Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials[J]. JAMA, 1995, 273(5) : 408-412.
  
13. Zhan SY. Proper use and reasonable interpretation of meta-analysis[J]. Zhonghua Er Ke Za Zhi, 2009, 47(12) : 883-886. Chinese.
  
14. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions. Version 5.1.0. The Cochrane Collaboration. 2011.
15. Luo H, Han M, Liu JP. Systematic review and meta-analysis of randomized controlled trials of Chinese herbal medicine in the treatment of Sjgren’s syndrome[J] J Chin Integr Med, 2011, 9(3) : 257-274. Chinese with abstract in English.
16. Liao J, Bi S. Clinical studies should be prospective: an interview to biomedical statistical expert Professor Hu Liangping. Zhongguo Yi Xue Lun Tan Bao. 2005-12-15. Chinese.
17. Liu JP. Current state and countermeasures on quality of randomized controlled studies of traditional Chinese medicine[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2003, 23(1) : 62-64. Chinese.
  
18. Li YP, Wu TX, Li J, Zhong ZH, Jia WN; Joint Statement Working Group, Chinese Clinical Trial Registration and Publishing Collaboration. Joint statement of establishing Chinese clinical trial registration and publishing system[J] J Chin Integr Med, 2006, 4(4) : 331-332. Chinese.
19. Shang HC, Zhang JH, Dai GH, Cao HB, Ren M, Xiang YZ, Wang Y, Zhang BL, Li YP. Administration and quality control of large scale clinical trials of traditional Chinese medicine[J] J Chin Integr Med, 2007, 5(1) : 1-4. Chinese with abstract in English.
20. Altman DG. Poor-quality medical research: what can journals do?[J]. JAMA, 2002, 287(21) : 2765-2767.
  
  
Reader's comments
1. louboutin pigalle 120 christian louboutin canada stores http://canadachristianlouboutinoutlet.blogspot.com/ (2016-1-28 0:00:00)

Send a comment

 Home | Current Issue | Past Issues | SearchRSS
Copyright © 2013-2018 by JIM Editorial Office. All rights reserved. ISSN 2095-4964; CN 31-2083/R. 沪ICP备110264号