Updated Friday, November 24, 2017
 Journal Tools
RSS Feed
Sample Copy
Submit a Manuscript
Contact Us
Subscription
Advertising
Thanking Peer Reviewers
 Language Polishing
Journal of Integrative Medicine: Volume 13, 2015   Issue 6,  Pages: 368–379

DOI: 10.1016/S2095-4964(15)60208-4
Review
Phytochemistry and pharmacology of ornamental gingers, Hedychium coronarium and Alpinia purpurata: a review
1. Eric Wei Chiang Chan (Faculty of Applied Sciences, UCSI University, Cheras 56000, Kuala Lumpur, Malaysia )
2. Siu Kuin Wong (School of Science, Monash University Sunway, Petaling Jaya 46150, Selangor, Malaysia )
ABSTRACT In this review, the phytochemistry and pharmacology of two ornamental gingers, Hedychium coronarium (butterfly ginger) and Alpinia purpurata (red ginger), are updated, and their botany and uses are described. Flowers of H. coronarium are large, showy, white, yellow or white with a yellow centre and highly fragrant. Inflorescences of A. purpurata are erect spikes with attractive red or pink bracts. Phytochemical investigations on the rhizomes of H. coronarium generated research interest globally. This resulted in the isolation of 53 labdane-type diterpenes, with little work done on the leaves and flowers. Pharmacological properties of H. coronarium included antioxidant, antibacterial, antifungal, cytotoxic, chemopreventive, anti-allergic, larvicidal, anthelminthic, analgesic, anti-inflammatory, anti-urolithiatic, anti-angiogenic, neuro-pharmacological, fibrinogenolytic, coagulant and hepatoprotective activities. On the contrary, little is known on the phytochemistry of A. purpurata with pharmacological properties of antioxidant, antibacterial, larvicidal, cytotoxic and vasodilator activities reported in the leaves and rhizomes. There is much disparity in terms of research effort within and between these two ornamental gingers.
Welcome to JIM! You are the number 4709 reader of this article!
Download Article:
[Full Text]      [PDF]      [Previous]      [Next]      [This Issue]
Please cite this article as:
Chan EWC, Wong SK. Phytochemistry and pharmacology of ornamental gingers, Hedychium coronarium and Alpinia purpurata: a review. J Integr Med. 2015; 13(6): 368–379.
References:
1Larsen K, Ibrahim H, Khaw SH, Saw LG. Gingers of Peninsular Malaysia and Singapore. Kota Kinabalu: Natural History Publications (Borneo). 1999.
2Ibrahim H. Hedychium. In: van Valkenburg JLCH, Bunyapraphatsara N. Plant resources of South-East Asia, 12(2): Medicinal and poisonous plants 2[M]. Leiden: Backhuys Publisher, 2001. 290–295.  
3Kress WJ, Liu AZ, Newman M, Li QJ. The molecular phylogeny of Alpinia (Zingiberaceae): a complex and polyphyletic genus of gingers[J].Am J Bot, 2005, 92(1): 167–178.  
4Wu D, Larsen K. Zingiberaceae. Flora of China, vol. 24. Beijing and St[M]. Louis: Science Press and Missouri Botanical Garden Press, 2000. 322–377. [2015-08-25]. http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=10960.  
5Shekhar TC, Anju G. A comprehensive review on Hedychium coronarium J. Koenig[J].Int J Res Ayurv Pharm, 2015, 6(1): 98–100.  
6Hartati R, Suganda AG, Fidrianny I. Botanical, phytochemical and pharmacological properties of Hedychium (Zingiberaceae) — A review[J].Procedia Chem, 2014, 13: 150–163.  
7Victório CP. Therapeutic value of the genus Alpinia, Zingiberaceae[J].Braz J Pharmacogn, 2011, 21(1): 194–201.  
8Ghosh S, Rangan L. Alpinia: the gold mine of future therapeutics[J].3 Biotech, 2013, 3(3): 173–185.  
9Kiem PV, Thuy NT, Anh Hle T, Nhiem NX, Minh CV, Yen PH, Ban NK, Hang DT, Tai BH, Tuyen NV, Mathema VB, Koh YS, Kim YH. Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells[J].Bioorg Med Chem Lett, 2011, 21(24): 7460–7465.  
10Ribeiro RA, Fiuza de Melo MM, De Barros F, Gomes C, Trolin G. Acute anti-hypertensive effect in conscious rats produced by some medicinal plants used in the state of S?o Paulo[J].J Ethnopharmacol, 1986, 15(3): 261–269.  
11Lu Y, Zhong CX, Wang L, Lu C, Li XL, Wang PJ. Anti-inflammation activity and chemical composition of flower essential oil from Hedychium coronarium[J].Afr J Biotechnol, 2009, 8(20): 5373–5377.  
12Jain SK, Fernandes VF, Lata S, Ayub A. Indo-Amazonian ethnobotanic connections — Similar uses of some common plants[J].Ethnobotany, 1995, 7: 29–37.  
13Manish M. Current status of endangered medicinal plant Hedychium coronarium and causes of population decline in the natural forests of Anuppur and Dindori districts of Madhya Pradesh, India[J].Int Res J Biol Sci, 2013, 2(3): 1–6.  
14Demetzos C, Dimas KS. Labdane-type diterpenes: Chemistry and biological activity[J].Stud Nat Prod Chem, 2001, 25: 235–292.  
15Taveira FN, Oliveira AB, Souza Filho JD, Braga FC. Epimers of labdane diterpenes from the rhizomes of Hedychium coronarium J. Koenig[J].Braz J Pharmacogn, 2005, 15(1): 55–59.  
16Endringer DC, Taveira FSN, Kondratyuk TP, Pezzuto JM, Braga FC. Cancer chemoprevention activity of labdane diterpenes from rhizomes of Hedychium coronarium[J].Braz J Pharmacogn, 2014, 24(4): 408–412.  
17Chimnoi N, Sarasuk C, Khunnawutmanotham N, Intachote P, Seangsai S, Saimanee B, Pisutjaroenpong S, Mahidol C, Techasakul S. Phytochemical reinvestigation of labdane-type diterpenes and their cytotoxicity from the rhizomes of Hedychium coronarium[J].Phytochem Lett, 2009, 2(4): 184–187.  
18Chen JJ, Ting CW, Wu YC, Hwang TL, Cheng MJ, Sung PJ, Wang TC, Chen JF. New labdane-type diterpenoids and anti-inflammatory constituents from Hedychium coronarium[J].Int J Mol Sci, 2013, 14(7): 13063–13077.  
19Itokawa H, Morita H, Katou I, Takeya K, Cavalheiro AJ, de Oliveira RC, Ishige M, Motidome M. Cytotoxic diterpenes from the rhizomes of Hedychium coronarium[J].Planta Med, 1988, 54(4): 311–315.  
20Kiem PV, Anh Hle T, Nhiem NX, Minh CV, Thuy NT, Yen PH, Hang DT, Tai BH, Mathema VB, Koh YS, Kim YH. Labdane-type diterpenoids from the rhizomes of Hedychium coronarium inhibit lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells[J].Chem Pharm Bull (Tokyo), 2012, 60(2): 246–250.  
21Zhan ZJ, Wen YT, Ren FY, Rao GW, Shan WG, Li CP. Diterpenoids and a diarylheptanoid from Hedychium coronarium with significant anti-angiogenic and cytotoxic activities[J].Chem Biodivers, 2012, 9(12): 2754–2760.  
22Nakatani N, Kikuzaki H, Yamaji H, Yoshio K, Kitora C, Okada K, Padolina WG. Labdane diterpenes from rhizomes of Hedychium coronarium[J].Phytochemistry, 1994, 37(5): 1383–1388.  
23Suresh G, Reddy PP, Babu KS, Shaik TB, Kalivendi SV. Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium[J].Bioorg Med Chem Lett, 2010, 20(24): 7544–7548.  
24Matsuda H, Morikawa T, Sakamoto Y, Toguchida I, Yoshikawa M. Labdane-type diterpenes with inhibitory effects on increase in vascular permeability and nitric oxide production from Hedychium coronarium[J].Bioorg Med Chem, 2002, 10(8): 2527–2534.  
25Morikawa T, Matsuda H, Sakamoto Y, Ueda K, Yoshikawa M. New farnesane-type sesquiterpenes, hedychiols A and V 8,9-diacetate, and inhibitors of degranulation in RBL-2h3 cells from the rhizome of Hedychium coronarium[J].Chem Pharm Bull (Tokyo), 2002, 50(8): 1045–1049.  
26Matsuda H, Morikawa T, Sakamoto Y, Toguchida I, Yoshikawa M. Antiinflammatory principles and three new labdane-type diterpenes, hedychilactones A, B, and C, from the rhizome of Hedychium coronarium Koenig[J].Heterocycles, 2002, 56(1–2): 45–50.  
27Singh S, Gray AI, Skelton BW, Waterman PG, White AH. (+)-14β-Hydroxylabda-8(17),12-dieno-16,15-lactone [(+)-isocoronarin D]: a new diterpene from Hedychium coronarium (Zingiberaceae)[J].Aust J Chem, 1991, 44(12): 1789–1793.  
28Singh S, Gray AI, Waterman PG. 14,15,16-Trinorlabda-8(17),11-(E)-dien-13-al: a trinorlabdane diterpene from the rhizome of Hedychium coronarium[J].Nat Prod Lett, 1993, 3(3): 163–166.  
29Lin YS, Lin JH, Chang CC, Lee SS. Tetrahydropyran- and tetrahydrofuran-containing diarylheptanoids from Hedychium coronarium rhizomes[J].J Nat Prod, 2015, 78(2): 181–187.  
30Nakamura S, Okazaki Y, Ninomiya K, Morikawa T, Matsuda H, Yoshikawa M. Medicinal flowers. XXIV. Chemical structures and hepatoprotective effects of constituents from flowers of Hedychium coronarium[J].Chem Pharm Bull, 2008, 56(12): 1704–1709.  
31Kunnumakkara AB, Ichikawa H, Anand P, Mohankumar CJ, Hema PS, Nair MS, Aggarwal BB. Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kB pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis[J].Mol Cancer Ther, 2008, 7: 3306–3317.  
32Aziz AM, Habib MR, Karim RM. Antibacterial and cytotoxic activities of Hedychium coronarium J. Koenig[J].Res J Agric Biol Sci, 2009, 5(6): 969–972.  
33Shrotriya S, Ali MS, Saha A, Bachar SC, Islam MS. Anti-inflammatory and analgesic effects of Hedychium coronarium Koen[J].Pak J Pharm Sci, 2007, 20(1): 47–51.  
34Dash PR, Nasrin M, Saha MR. Evaluation of analgesic and neuropharmacological activities of methanolic rhizome extract of Hedychium coronarium[J].Int J Pharm Sci Res, 2011, 2(4): 979–984.  
35Bahuguna YM, Kumar N. Phytochemical and pharmacological evaluation of Hedychium coronarium J. Koenig for antiurolithiatic acfivity[J].World J Pharm Sci, 2014, 2(1): 112–122.  
36Chan EWC, Lim YY, Wong LF, Lianto FS, Wong SK, Lim KK, Joe CE, Lim TY. Antioxidant and tyrosinase inhibition properties of leaves and rhizomes of ginger species[J].Food Chem, 2008, 109(3): 477–483.  
37Ribeiro Rde A, de Barros F, de Melo MM, Muniz C, Chieia S, Wanderley M das G, Gomes C, Trolin G. Acute diuretic effects in conscious rats produced by some medicinal plants used in the state of S?o Paulo, Brasil[J].J Ethnopharmacol, 1988, 24(1): 19–29.  
38Zeng Y, Zhao J, Peng Y. A comparative study on the free radical scavenging activities of some fresh flowers in southern China[J].LWT ? Food Sci Technol, 2008, 41(9): 1586–1591.  
39Pandya CV, Jadeja AJ, Golakiya BA. Antifungal activity of crude extracts of Hedychium coronarium[J].Int J Res Phytochem Pharmacol, 2014, 3(4): 163–165.  
40Ali S, Sotheeswaran S, Tuiwawa M, Smith RM. Comparison of the composition of the essential oils of Alpinia and Hedychium species—essential oils of Fijian plants, Part 1[J].J Essent Oil Res, 2002, 14(6): 409–411.  
41Lechat-Vahirua I, Francois P, Menut C, Lamaty G, Bessiere JM. Aromatic plants of French Polynesia. I. Constituents of the essential oils of rhizomes of three Zingiberaceae: Zingiber zerumbet Smith, Hedychium coronarium Koenig and Etlingera cevuga Smith[J].J Essent Oil Res, 1993, 5(1): 55–59.  
42Gurib-Fakim A, Maudarbaccus N, Leach D, Doimo L, Wohlmuth H. Essential oil composition of Zingiberaceae species from Mauritius[J].J Essent Oil Res, 2002, 14(4): 271–273.  
43Van Thanh B, Dai do N, Thang TD, Binh NQ, Anh LD, Ogunwande IA. Composition of essential oils of four Hedychium species from Vietnam[J].Chem Central J, 2014, 8(1): 54.  
44Parida R, Mohanty S, Nayak S. Chemical composition of essential oil from leaf and rhizome of micropropagated and conventionally grown Hedychium coronarium Koen. from Eastern India[J].J Essent Oil Bear Plant, 2015, 18(1): 161–167.  
45Joy B, Rajan A, Abraham E. Antimicrobial activity and chemical composition of essential oil from Hedychium coronarium[J].Phytother Res, 2007, 21(5): 439–443.  
46Prakash O, Rajput M, Kumar M, Pant AK. Chemical composition and antibacterial activity of rhizome oils from Hedychium coronarium Koenig and Hedychium spicatum Buch-Ham[J].J Essent Oil Bear Plant, 2010, 13(2): 250–259.  
47Ho JC. Antimicrobial, mosquito larvicidal and antioxidant properties of the leaf and rhizome of Hedychium coronarium[J].J Chin Chem Soc, 2011, 58(4): 563–567.  
48Shanmugam PV, Yadav A, Chanotiya CS. Enantiomer differentiation of key volatile constituents from leaves, stems, rhizomes and flowers of cultivated Hedychium coronarium Koenig from India[J].J Essent Oil Res, 2015, 27(2): 101–106.  
49Miranda CASF, Cardoso MG, Mansanares ME, Gomes MS, Marcussi S. Preliminary assessment of Hedychium coronarium essential oil on fibrinogenolytic and coagulant activity induced by Bothrops and Lachesis snake venoms[J].J Venom Anim Toxin Trop Dis, 2014, 20: 39.  
50Dixit VK, Varma KC. Anthelmintic properties of essential oils from rhizomes of Hedychium coronarium Koenig and Hedychium spicatum Koenig (sheep, goats and pigs)[J].Indian J Pharm, 1975, 37(6): 143–144.  
51Dixit VK, Varma KC. Effect of essential oils of rhizomes of Hedychium coronarium and Hedychium spicatum on central nervous system[J].Indian J Pharm, 1979, 11(2): 147–149.  
52Omata A, Yomogida K, Teshima Y, Nakamura S, Hashimoto S, Arai T, Furukawa K. Volatile components of ginger flowers (Hedychium coronarium Koenig)[J].Flavour Frag J, 1991, 6(3): 217–220.  
53Matsumoto F, Idetsuki H, Harada K, Nohara I, Toyoda T. Volatile components of Hedychium coronarium Koenig flowers[J].J Essent Oil Res, 1993, 5(2): 123–133.  
54Báez D, Pino JA, Morales D. Floral scent composition in Hedychium coronarium J. Koenig analyzed by SPME[J].J Essent Oil Res, 2011, 23(3): 64–67.  
55Kobayashi KD, McEwen J, Kaufman AJ. Ornamental ginger, red and pink[M]. Ornamentals and Flowers, OF-37, College of Tropical Agriculture and Human Resources, Honolulu: University of Hawaii, 2007. 1–8.  
56Ng FSP. Zingiberaceae. Tropical horticulture and gardening[M]. Kuala Lumpur: Clearwater Publications, 2006. 118–125.  
57Raj CA, Ragavendran P, Sophia D, Rathi MA, Gopalakrishnan VK. Evaluation of in vitro antioxidant and anticancer activity of Alpinia purpurata[J].Chin J Nat Med, 2012, 10(4): 263–268.  
58Mohd Sirat H, Liamen MR. Chemical constituents of Alpinia purpurata[J].Pertanika J Sci Technol, 1995, 3(1): 67–71.  
59Jovitta CJ, Aswathi S, Suja S. In-vitro antioxidant and phytochemical screening of ethanolic extract of Alpinia purpurata[J].Int J Pharm Sci Res, 2012, 3(7): 2071–2074.  
60Subramanian V, Suja S. Evaluation of antioxidant activity of Alpinia purpurata rhizome[J].Int J Res Pharm Sci, 2011, 2(4): 601–607.  
61Kochuthressia KP, Britto SJ, Jaseentha MO, Raj LJM, Senthilkumar SR. Antimicrobial efficacy of extracts from Alpinia purpurata (Vieill.) K. Schum. against human pathogenic bacteria and fungi[J].Agric Biol J N Am, 2010, 1(6): 1249–1252.  
62Victório CP, Kuster RM, Lage CLS. Detection of flavonoids in Alpinia purpurata (Vieill.) K. Schum. leaves using high performance liquid chromatography[J].Brazil J Med Plants, 2009, 11(2): 147–153.  
63Villaflores OB, Macabeo AP, Gehle D, Krohn K, Franzblau SG, Aquinaldo AM. Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis[J].Pharmacogn Mag, 2010, 6(24): 339–344.  
64Wong LF, Lim YY, Omar M. Antioxidant and antimicrobial activities of some Alpina species[J].J Food Biochem, 2009, 33: 835–851.  
65Victório CP, Kuster RM, de Moura RS, Lage CLS. Vasodilator activity of extracts of field Alpinia purpurata (Vieill) K. Schum and A. zerumbet (Pers.) Burtt et Smith cultured in vitro[J].Braz J Pharm Sci, 2009, 45(3): 507–514.  
66da Silva AT, de Lima EM, Caliman IF, Souza Porto LL, do Nascimento AM, Kalil IC, Lenz D, Bissoli NS, Endringer DC, de Andrade TU. Hypotensive effect and endothelium-dependent vascular action of leaves of Alpinia purpurata (Vieill) K. Schum[J].Braz J Pharm Sci, 2014, 50(2): 309–320.  
67Arul Raj C, Sophia D, Ragavendran P, Starlin T, Rathi MA, Gopalakrishnan VK. Leaf extract of Alpinia purpurata (Vieill.) K. Schum screened for its phytochemical constituents and antibacterial and anticancer activities[J]. J Chin Integr Med, 2012, 10(12): 1460–1464.  
68Zoghbi MGB, Andrade EHA, Maia JGS. Volatile constituents from leaves and flowers of Alpinia speciosa K. Schum. and A. purpurata (Vieill.) Schum[J].Flavour Frag J, 1999, 14(6): 411–414.  
69Victório CP, Leit?o SG, Lage CLS. Chemical composition of the leaf oils of Alpinia zerumbet (Pers.) Burtt et Smith and A. purpurata (Vieill.) K. Schum. from Rio de Janeiro, Brazil[J].J Essent Oil Res, 2010, 22(1): 52–54.  
70Rialita T, Rahayu WP, Nuraida L, Nurtama B. Antimicrobial activity of red ginger (Zingiber officinale var. rubrum) and red galangal (Alpinia purpurata K. Schum.) essential oils against pathogenic and food spoilage bacteria[J].Agritech, 2015, 35(1): 43–52.  
71Santos GKN, Dutra KA, Barros RA, da Camara CAG, Lira DD, Gusm?o NB, Navarro DMAF. Essential oils from Alpinia purpurata (Zingiberaceae): Chemical composition, oviposition deterrence, larvicidal and antibacterial activity[J].Indust Crop Prod, 2012, 40: 254–260.  
72de Lira CS, Pontual EV, de Albuquerque LP, Paiva LM, Paiva PMG, de Oliveira JV, Napole?o TH, Ferraz Navarro DMA. Evaluation of the toxicity of essential oil from Alpinia purpurata inflorescences to Sitophilus zeamais (maize weevil)[J].Crop Prot, 2015, 71: 95–100.  
 Home | Current Issue | Past Issues | SearchRSS
Copyright © 2013-2018 by JIM Editorial Office. All rights reserved. ISSN 2095-4964; CN 31-2083/R. 沪ICP备110264号