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Journal of Integrative Medicine: Volume 15, 2017   Issue 6,  Pages: 462–468

DOI: 10.1016/S2095-4964(17)60353-4
Research Article
Inhibitory effect of Phlai capsules on skin test responses among allergic rhinitis patients: ?a randomized, three-way crossover study
1. Pattara Tanticharoenwiwat (Center of Excellence for Allergy, Asthma and Pulmonary Disease, Thammasat University Hospital, Pathumthani 12120, Thailand )
2. Prapasri Kulalert (Center of Excellence for Allergy, Asthma and Pulmonary Disease, Thammasat University Hospital, Pathumthani 12120, Thailand )
3. Thaweephol Dechatiwongse Na Ayudhya (Medicinal Herb Research Unit for Asthma, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand )
4. Sittichai Koontongkaew (Medicinal Herb Research Unit for Asthma, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand )
5. Weena Jiratchariyakul (Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand )
6. Ruedee Soawakontha (Faculty of Pharmaceutical Sciences, Huachiew Chalermprekiet University, Samut Prakan 10540, Thailand )
7. Prakongsiri Booncong (Department for Development of Thai Traditional and Alternative Medicine, Ministry of Public Health, Nonthaburi 11000, Thailand )
8. Orapan Poachanukoon (Center of Excellence for Allergy, Asthma and Pulmonary Disease, Thammasat University Hospital, Pathumthani 12120, Thailand )
ABSTRACT BACKGROUND: Zingiber cassumunar Roxb., commonly known as Phlai in Thai, has been used as a traditional medicine in Thailand for the treatment of various diseases, including inflammation and chronic airway disease. OBJECTIVE: The purpose of this study was to assess the antihistaminic effect of Phlai on skin testing. DESIGN, SETTING, PARTICIPANTS AND INTERVENTION: This was a randomized, open-label, three-way crossover study. Twenty allergic rhinitis (AR) patients were enrolled. In randomized sequence, patients received a single dose of Phlai capsules (100 or 200 mg) or loratadine (10 mg) with a washout period of 1 week between each treatment. MAIN OUTCOME MEASURES: Skin prick testing for histamine and common aeroallergen (house dust mite) were performed before treatment and after 1, 2, 3, 4, 6, 8, 12 and 24 hours of treatment. The main treatment outcomes were the mean wheal and flare responses to the skin prick test after treatment. RESULTS: Both 100 mg and 200 mg Phlai doses suppressed wheal and flare responses to house dust mite allergen, but only 200 mg of Phlai capsules significantly suppressed wheal and flare responses to histamine. Repeated measures analysis of variance showed that loratadine caused more wheal and flare suppression than Phlai capsules in responses to the histamine skin prick test. However, there were no significant differences among the effects of 100 mg Phlai capsules, 200 mg Phlai capsules and loratadine in suppression of wheal and flare induced by the mite skin prick test. Both doses of Phlai were well-tolerated with no adverse events.
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Tanticharoenwiwat P, Kulalert P, Dechatiwongse Na Ayudhya T, Koontongkaew S, Jiratchariyakul W, Soawakontha R, Booncong P, Poachanukoon O. Inhibitory effect of Phlai capsules on skin test responses among allergic rhinitis patients: a randomized, three-way crossover study. J Integr Med. 2017; 15(6): 462–468.
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