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Journal of Integrative Medicine: Volume 16, 2018   Issue 5,  Pages: 329-334

DOI: 10.1016/j.joim.2018.05.006
Original Clinical Research
TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: a randomized, double-blind, placebo-controlled trial
1. MehranghizEbrahimi-Mameghani (Nutrition Research Center, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran )
2. MohammadAsghari-Jafarabadi (Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran )
3. KhaterehRezazadeh (Student Research Committee, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran E-mail: rezazadekhatere@gmail.com)

Abstract

BACKGROUND: Transcription factor 7-like 2 (TCF7L2)-rs7903146 polymorphism is associated with increased risk of type 2 diabetes. The response of insulin and insulin resistance to artichoke leaf extract (ALE) may be affected by TCF7L2-rs7903146 polymorphism.
OBJECTIVE: This study examined the effects of ALE supplementation on metabolic parameters of the TCF7L2-rs7903146 polymorphism in patients with metabolic syndrome (MetS).
DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: This double-blind clinical trial was conducted on 80 patients with MetS in Sina Clinic, Khoy, Iran. The patients were randomized into ALE or placebo groups to receive either ALE (1800 mg/d as four tablets) or matching placebo for 12 weeks.
MAIN OUTCOME MEASURES: Anthropometric indices, blood pressure, glucose and lipid profile levels were measured before and after the study. Moreover, patients were genotyped for TCF7L2 polymorphism.
RESULTS: ALE supplementation decreased insulin level and the homeostasis model assessment of insulin resistance (HOMA-IR) in patient with the TT genotype of TCF7L2-rs7903146 polymorphism (P < 0.05). There was no significant interaction between blood pressure, glucose and lipid profile response to ALE supplementation.
CONCLUSION: The responses of insulin and HOMA-IR to ALE supplementation have shown an interaction with single-nucleotide polymorphism rs7903146 in TCF7L2.
TRIAL REGISTRATION: Iranian Registry of Clinical Trial IRCT201409033320N9.
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Please cite this article as:
MehranghizEbrahimi-Mameghani, MohammadAsghari-Jafarabadi, KhaterehRezazadeh. TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: a randomized, double-blind, placebo-controlled trial. J Integr Med. 2018; 16(5): 329-334.
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