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Journal of Integrative Medicine: Volume 16, 2018   Issue 5,  Pages: 322-328

DOI: 10.1016/j.joim.2018.06.001
Original Clinical Research
Effects of vitamin supplementation on inflammatory markers and psychological wellbeing among distressed women: a randomized controlled trial
1. Jodie M.Oliver-Baxter (School of Psychology, the University of Adelaide, Adelaide, South Australia 5005, Australia )
2. Hayley S.Whitford (Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia 5001, Australia )
3. Deborah A.Turnbull (School of Psychology, the University of Adelaide, Adelaide, South Australia 5005, Australia )
4. Malcolm J.Bond (School of Medicine, Flinders University, GPO Box 2100, Adelaide, South Australia 5001, Australia E-mail: malcolm.bond@flinders.edu.au)

Abstract

BACKGROUND: Multivitamins are a popular supplement taken to promote physical and mental health. During periods of stress, they may have a protective role for health and wellbeing, although the current evidence of their efficacy is mixed.
OBJECTIVE: To determine whether multivitamin supplementation impacts psychological and inflammatory markers of women who are experiencing psychological distress.
DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: An 8-week randomized controlled trial was conducted to assess changes in both psychological state and pro-inflammatory markers of patients receiving multivitamins or placebo. The sample comprised women who reported elevated psychological distress in the previous 4 weeks.
MAIN OUTCOME MEASURES: Psychological state was assessed using Spielberger’s State-Trait Personality Inventory to assess anxiety, curiosity, depression and anger. Pro-inflammatory markers comprised interleukin (IL)-1β, IL-5, IL-6, tumour necrosis factor (TNF)-α and TNF-β.
RESULTS: Improvements across time were observed for all psychological measures and cytokines, except IL-5, but were independent of the active intervention. Only TNF-β demonstrated a significant differential change between groups over the course of the intervention, in favour of multivitamin supplementation (active group mean rank decreased from 11.1 to 7.1; placebo group mean rank decreased from 8.9 to 7.8).
CONCLUSION: The results suggest that administration of multivitamins was not effective in improving psychological state. However, some evidence supported the positive impact of multivitamin supplementation on pro-inflammatory cytokine profiles of women currently experiencing stress.
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Please cite this article as:
Jodie M.Oliver-Baxter, Hayley S.Whitford, Deborah A.Turnbull, Malcolm J.Bond. Effects of vitamin supplementation on inflammatory markers and psychological wellbeing among distressed women: a randomized controlled trial. J Integr Med. 2018; 16(5): 322-328.
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