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Journal of Chinese Integrative Medicine: Volume 10, 2012   Issue 2,  Pages: 117-127

DOI: 10.3736/jcim20120201
Review Article
A recent update in research on the antihepatotoxic potential of medicinal plants
1. Anju Dhiman (Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, Haryana, India E-mail: ad_mdu@rediffmail.com)
2. Arun Nanda (Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, Haryana, India )
3. Sayeed Ahmad (Bioactive Natural Product Laboratory, Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India )
ABSTRACT: Hepatic damage is a global metabolic and epidemic disease, affecting essential biochemical activities in almost every age group. Conventional drugs used in the treatment of liver disorders are often inadequate. Also, the spectrum of liver abnormalities caused by allopathic drugs is found to be broad. In view of severely undesirable side effects of synthetic agents, it is necessary to search for alternative drugs for the treatment of liver diseases to replace the currently used drugs, which are of doubtful efficacy and safety. Therefore, there is growing focus to follow systematic research methodology and to evaluate scientific basis for the traditional herbal medicines that are claimed to possess hepatoprotective activities. Use of herbal drugs in the treatment of liver diseases has a long tradition, especially in Eastern medicine and can be traced back as far as 2100 B.C. in ancient China (Xia Dynasty) and India (Vedic period), but evidence for efficacy is sparse. The current study is aimed at providing an overview of clinical and experimental studies carried out on the most effective and commonly used hepatoprotective plants and their beneficial aspects.
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Please cite this article as:
Dhiman A, Nanda A, Ahmad S. A recent update in research on the antihepatotoxic potential of medicinal plants. J Chin Integr Med / Zhong Xi Yi Jie He Xue Bao. 2012; 10(2): 117-127.
References:
1Sharma A, Shanker C, Tyagi LK, Singh M, Rao CV. Herbal medicine for market potential in India: an overview[J].Acad J Plant Sci, 2008, 1(2): 26-36.  
2Trivedi N, Rawal UM. Hepatoprotective and toxicological evaluation of Andrographis paniculata on severe liver damage[J].Indian J Pharmacol, 2000, 32(5): 288-293.  
3Sanmugapriya E, Venkataraman S. Studies on hepatoprotective and antioxidant actions of Strychnos potatorum Linn. seeds on CCl4-induced acute hepatic injury in experimental rats[J].J Ethnopharmacol, 2006, 105(1-2): 154-160.  
4Samudram P, Rajeshwari H, Vasuki R, Geetha A, Sathiya moorthi P. Hepatoprotective activity of Bi-herbal ethanolic extract on CCl4 induced hepatic damage in rats[J].Afr J Biochem Res, 2008, 2(2): 61-65.  
5Lavhale MS, Mishra SH. Nutritional and therapeutic potential of Ailanthus excelsa — a review[J].Phcog Rev, 2007, 1(1): 105-113.  
6Chopra RN, Nayar SL, Chopra IC. Glossary of Indian medicinal plants. New Delhi: NISCAIR. 1956.
7Salna KP, Sreejith K, Uthiralingam M, Prince MA, John Milton MC, Fleming AT. A comparative study of phytochemicals investigation of Andrographis paniculata and Murraya koenigii[J].Int J Pharm Pharm Sci, 2011, 3(3): 291-292.  
8Trivedi NP, Rawal UM. Hepatoprotective and antioxidant property of Andrographis paniculata (Nees) in BHC induced liver damage in mice[J].Indian J Exp Biol, 2001, 39(1): 41-46.  
9Arulmozhi S, Mazumder PM, Purnima A, Narayanan LS. Pharmacological activities of Alstonia scholaris Linn. (Apocynaceae) — a review[J].Phcog Rev, 2007, 1(1): 163-170.  
10Ghosh T, Maity TK, Das M, Bose A, Dash GK. Hepatoprotective activity of Bacopa monnieri L. against ethanol-induced hepatotoxicity in rats[J].Phcog Mag, 2007, 3(10): 95-100.  
11Murugesh KS, Yeligar VC, Maiti BC, Maity TK. Hepatoprotective and antioxidant role of Berberis tinctoria Lesch leaves on paracetamol induced hepatic damage in rats[J].Iran J Pharmacol Ther, 2005, 4(1): 64-69.  
12Rawat AK, Mehrotra S, Tripathi SC, Shome U. Hepatoprotective activity of Boerhaavia diffusa L. roots: a popular Indian ethnomedicine[J].J Ethnopharmacol, 1997, 56(1): 61-66.  
13Chandan BK, Sharma AK, Anand KK. Boerhaavia diffusa: a study of its hepatoprotective activity. J Ethnopharmacol. 1991; 31(3): 299-307.
14Ali M, Ramachandram R, Rafiullah MRM, Singh O, Siddiqui AW, Mir SR. Prevention of carbon tetrachloride-induced hepatotoxicity by the ethanol extract of Capparis moonii fruits in rats[J].Pharm Biol, 2004, 42(4-5): 286-288.  
15Gupta AK, Misra N. Hepatoprotective activity of aqueous ethanolic extract of Chamomile capitula in paracetamol intoxicated albino rats[J].Am J Pharmacol Toxicol, 2006, 1(1): 17-20.  
16Madani H, Talebolhosseini M, Asgary S, Naderi GH. Hepatoprotective activity of Silybum marianum and Cichorium intybus against thioacetamide in rats[J].Pak J Nutr, 2008, 7(1): 172-176.  
17Heibatollah S, Reza NM, Izadpanah J, Sohailla S. Hepatoprotective effect of Cichorium intybus on CCl4-induced liver damage in rats[J].Afr J Biochem Res, 2008, 2(6): 141-144.  
18Sultana S, Perwaiz S, Iqbal M, Athar M. Crude extracts of hepatoprotective plants, Solanum nigrum and Cichorium intybus inhibit free radical-mediated DNA damage[J].J Ethnopharmacol, 1995, 45(3): 189-192.  
19Bhavsar SK, Joshi P, Shah MB, Santani DD. Investigation into hepatoprotective activity of Citrus limon[J].Pharm Biol, 2007, 45(4): 303-311.  
20Kangralkar VA, Gavimath CC, Vijapur V, Gowri VB, Hooli VR, Mathapati P. Protective effect of essential oil of Citrus reticulata on isoniazid induced hepatotoxicity in Wistar rats[J].Int J Pharm Appl, 2010, 1(2): 59-61.  
21Sengottuvelu S, Duraisamy R, Nandhakumar J, Sivakumar T. Hepatoprotective activity of Cleome viscosa against carbon tetrachloride induced hepatotoxicity in rats[J].Phcog Mag, 2007, 3(10): 120-123.  
22Parrotta JA. Healing plants of peninsular India[M]. New York: CABI Publishing, 2001. 263.  
23Pandey A, Bigoniya P, Raj V, Patel KK. Pharmacological screening of Coriandrum sativum Linn. for hepatoprotective activity[J].J Pharm Bioallied Sci, 2011, 3(3): 435-441.  
24Omar R, Rahman A, Latif Z, Lihan MT, Adam JH. Hepatoprotective effects of Curcuma longa rhizomes in paracetamol-induced liver damage in rats. Proceedings of the Regional Symposium on Environment and Natural Resources, Lumpur, Malaysia, April 10-11, 2002.
25Evans WC. Trease and Evans’ pharmacognosy. 14th ed[M]. Noida: Gopsons Papers Ltd, 1997. 438.  
26Wallis TE. Textbook of pharmacognosy. 5th ed[M]. New Delhi: CBS Publishers and Distributors, 2005. 388.  
27Dewick PM. Medicinal natural products — a biosynthetic approach. 3rd ed[M]. Chichester: John Wiley and Sons, Ltd, 2009. 167.  
28Jariyawat S, Suksen K, Chuncharunee A, Sophasan S, Piyachaturawat P. Evaluation on the hepatoprotective effects of the standard extracts from Curcuma longa and Andrographis paniculata. 31st Congress on Science and Technology of Thailand at Suranaree University of Technology, Suranaree, Thailand, October 18-20, 2005.
29Rai PK, Kumar R, Malhotra Y, Sharma D, Karthiyagini T. Standardisation and preliminary phytochemical investigation on Cyperus rotundus Linn rhizome[J].Int J Res Ayurveda Pharm, 2010, 1(2): 536-542.  
30Suresh Kumar SV, Mishra SH. Hepatoprotective activity of rhizomes of Cyperus rotundus Linn against carbon tetrachloride-induced hepatotoxicity[J].Indian J Pharm Sci, 2005, 67(1): 84-88.  
31Senthilkumar KTM, Rajkapoor B, Kavimani S. Protective effect of Enicostemma littorale against CCl4-induced hepatic damage in rats[J].Pharm Biol, 2005, 43(5): 485-487.  
32Channabasavaraj KP, Badami S, Bhojraj S. Hepatoprotective and antioxidant activity of methanol extract of Ficus glomerata[J].J Nat Med, 2008, 62(3): 379-383.  
33van Rossum TG, Vulto AG, Hop WC, Brouwer JT, Niesters HG, Schalm SW. Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized, placebo-controlled phase Ⅰ/Ⅱ trial[J].J Gastroenterol Hepatol, 1999, 14(11): 1093-1099.  
34Rajesh MG, Latha MS. Protective activity of Glycyrrhiza glabra Linn. on carbon tetrachloride-induced peroxidative damage[J].Indian J Pharmacol, 2004, 36: 284-287.  
35Lee JS, Kim HS, Lee YJ, Han G, Kim JA, Lee JS. Hepatoprotective and immune modulating effects of Grifola frondosa water extract on the CCl4-induced liver injury in rats[J].FASEB J, 2007, 21: 852.  
36Dash DK, Yeligar VC, Nayak SS, Ghosh T, Rajalingam D, Gupta PS, Maiti BC, Maity TK. Evaluation of hepatoprotective and antioxidant activity of Ichnocarpus frutescens (Linn.) R. Br. on paracetamol-induced hepatotoxicity in rats[J].Trop J Pharm Res, 2007, 6(3): 755-765.  
37Jasemine S, Srivastava RS, Singh SK. Hepatoprotective effect of crude extract and isolated lignans of Justicia simplex against CCl4-induced hepatotoxicity[J].Pharm Biol, 2007, 45(4): 274-277.  
38Jalalpure SS, Patil MB, Jabshetti MS. Effect of Lawsonia alba leaf extracts on carbon tetrachloride-induced hepatic damage in albino rats[J].J Nat Rem, 2003, 3(1): 97-100.  
39Bhandarkar M, Khan A. Protective effect of Lawsonia alba Lam., against CCl4 induced hepatic damage in albino rats[J].Indian J Exp Biol, 2003, 41(1): 85-87.  
40Ahmed S, Rahman A, Alam A, Saleem M, Athar M, Sultana S. Evalation of the efficacy of Lawsonia alba in the alleviation of carbon tetrachloride-induced oxidative stress[J].J Ethnopharmacol, 2000, 69(2): 157-164.  
41Qureshi MN, Kuchekar BS, Logade NA, Haleem MA. In-vitro antioxidant and in-vivo hepatoprotective activity of Leucas ciliata leaves[J].Rec Nat Prod, 2010, 4(2): 124-130.  
42Uhegbu FO, Elekwa I, Akubugwo EI, Chinyere GC, Iweala EEJ. Analgesic and hepatoprotective activity of methanolic leaf extract of Ocimum gratissimum (L.)[J].Res J Med Plant, 2012, 6(1): 108-115.  
43Suresh Kumar SV, Mishra SH. In-vitro evaluation of hepatoprotective activity of Pergularia daemia Forsk[J].Phcog Mag, 2008, 4(16): 298-302.  
44Chatterjee M, Sil PC. Protective role of Phyllanthus niruri against nimesulide induced hepatic damage[J].Indian J Clin Biochem, 2007, 22(1): 109-116.  
45Arun M, Asha VV. Preliminary studies on antihepatotoxic effect of Physalis peruviana Linn. (Solanaceae) against carbon tetrachloride induced acute liver injury in rats[J].J Ethnopharmacol, 2007, 111(1): 110-114.  
46Chang JC, Lin CC, Wu SJ, Lin DL, Wang SS, Miaw CL, Ng LT. Antioxidative and hepatoprotective effects of Physalis peruviana extract against acetaminophen-induced liver injury in rats[J].Pharm Biol, 2008, 46(10-11): 724-731.  
47Perez Gutierrez RM, Anaya Sosa I, Hoyo Vadillo C, Victoria TC. Effect of flavonoids from Prosthechea michuacana on carbon tetrachloride induced acute hepatotoxicity in mice[J].Pharm Biol, 2011, 49(11): 1121-1127.  
48Kamath JV, Rahul N, Ashok Kumar CK, Lakshmi SM. Psidium guajava L: a review[J].Int J Green Pharm, 2008, 2(1): 9-12.  
49Gutiérrez RM, Mitchell S, Solis RV. Psidium guajava: a review of its traditional uses, phytochemistry and pharmacology[J].J Ethnopharmacol, 2008, 117(1): 1-27.  
50Mankani KL, Krishna V, Manjunatha BK, Vidya SM, Jagadeesh Singh SD, Manohara YN, Raheman A, Ainash KR. Evaluation of hepatoprotective activity of stem bark of Pterocarpus marsupium Roxb[J].Indian J Pharmacol, 2005, 37(3): 165-168.  
51Manjunatha BK. Hepatoprotective activity of Pterocarpus santalinus L.f., an endangered medicinal plant[J].Indian J Pharmcol, 2006, 38(1): 25-28.  
52Dhanabal SP, Syamala G, Elango K, Suresh B. Protective effect of Pterocarpus santalinus on galactosamine induced liver damage[J].Nat Prod Sci, 2006, 12(1): 8-13.  
53Yogeeta SK, Ragavender HRB, Devaki T. Antihepatotoxic effect of Punica granatum acetone extract against isoniazid- and rifampicin-induced hepatotoxicity[J].Pharm Biol, 2007, 45(8): 631-637.  
54Pradeep K, Mohan CVR, Gobianand K, Karthikeyan S. Silymarin: an effective hepatoprotective agent against diethylnitrosamine-induced hepatotoxicity in rats[J].Pharm Biol, 2007, 45(9): 707-714.  
55Lin HM, Tseng HC, Wang CJ, Lin JJ, Lo CW, Chou FP. Hepatoprotective effects of Solanum nigrum Linn extract against CCl4-induced oxidative damage in rats[J].Chem Bio Interact, 2008, 171(3): 283-293.  
56Raju K, Anbuganapathi G, Gokulakrishnan V, Rajkapoor B, Jayakar B, Manian S. Effect of dried fruits of Solanum nigrum LINN against CCl4-induced hepatic damage in rats[J].Bio Pharm Bull, 2003, 26(11): 1618-1619.  
57Kuriakose GC, Kurup MG. Antioxidant and antihepatotoxic effect of Spirulina laxissima against carbon tetrachloride induced hepatotoxicity in rats[J].Food Funct, 2011, 2(3-4): 190-196.  
58Park JY, Park CM, Kim JJ, Song YS. Hepatoprotective activity of dandelion (Taraxacum of ficinale) water extract against D-galactosamine-induced hepatitis in rats[J].J Korean Soc Food Sci Nut, 2008, 32(2): 177-183.  
59Park CM, Cha YS, Youn HJ, Cho CW, Song YS. Amelioration of oxidative stress by dandelion extract through CYP2E1 suppression against acute liver injury induced by carbon tetrachloride in Sprague-Dawley rats[J].Phytother Res, 2010, 24(9): 1347-1353.  
60Sree RM, Srinivasan M. Hepatoprotective effect of Tephrosia pupurea in experimental animals[J].Indian J Pharmacol, 1993, 25(1): 34-36.  
61Khatri A, Garg A, Agrawal SS. Evaluation of hepatoprotective activity of aerial parts of Tephrosia purpurea L. and stem bark of Tecomella undulata[J].J Ethnopharmacol, 2009, 122(1): 1-5.  
62Panovska TK, Kulevanova S, Gjorgoski I, Bogdanova M, Petrushevska G. Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats[J].Acta Pharm, 2007, 57(2): 241-248.  
63Sharmila Banu G, Kumar G, Murugesan AG. Effect of ethanolic leaf extract of Trianthema portulacastrum L. on aflatoxin induced hepatic damage in rats[J].Indian J Clin Biochem, 2009, 24(4): 414-418.  
64Mujeeb M, Aeri V, Bagri P, Khan SA. Hepatoprotective activity of the methanolic extract of Tylophora indica (Burm. f.) Merill. leaves[J].Int J Green Pharm, 2009, 3(2): 125-127.  
65Gujrati V, Patel N, Rao VN, Nandakumar K, Gouda TS, Shalam M, Shanta Kumar SM. Hepatoprotective activity of alcoholic and aqueous extracts of leaves of Tylophora indica (Linn.) in rats[J].Indian J Pharmacol, 2007, 39(1): 43-47.  
66Iwalokun BA, Efedede BU, Alabi-Sofunde JA, Oduala T, Magbagbeola OA, Akinwande AI. Hepatoprotective and antioxidant activities of Vernonia amygdalina on acetaminophen-induced hepatic damage in mice[J].J Med Food, 2006, 9(4): 524-530.  
67Joshua AJ, Goudar KS, Sameera N, Kumar GP, Murali B, Dinakar N, Amit A. Safety assessment of herbal formulations, RumbionTM and TyrelTM in albino Wistar rats[J].Am J Pharmacol Toxicol, 2010, 5(1): 42-47.  
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