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Journal of Chinese Integrative Medicine: Volume 10, 2012   Issue 3,  Pages: 256-263

DOI: 10.3736/jcim20120303
Review Article
Advances in Smoothened-targeting therapies for pancreatic cancer: implication for drug discovery from herbal medicines
1. Jin-bin Han (Department of Integrative Oncology, Shanghai Cancer Center, Fudan University, Shanghai 200032, China )
2. Yong-qiang Hua (Department of Integrative Oncology, Shanghai Cancer Center, Fudan University, Shanghai 200032, China )
3. Lian-yu Chen (Department of Integrative Oncology, Shanghai Cancer Center, Fudan University, Shanghai 200032, China )
4. Lu-ming Liu (Department of Integrative Oncology, Shanghai Cancer Center, Fudan University, Shanghai 200032, China E-mail: llm1010@163.com)
ABSTRACT: Smoothened (SMO) is a member of sonic hedgehog homology (SHH) signaling pathway. It plays a key role as a bridge between patched-1 (PTCH-1) and Gli. Aberrant SHH expression can be detected in various malignant tissues, and the expression in pancreatic cancer stem cells is higher apparently. SHH signals are closely associated with self-duplication of cancer stem cells, formation of tumor vessels as well as matrixes. SMO antagonists such as cyclopamine, GDC-0449 and so on show potential to inhibit activity of SHH signaling, and arrest the growth as well as metastases of tumors. Recently, a few of SMO antagonists have been studied in phase Ⅰ clinical trials and some are in phase Ⅱ, meanwhile, phase Ⅰ or Ⅱ trials of SMO antagonists to treat pancreatic cancer are performed currently. As the classical SMO antagonist, cyclopamine is extracted from a medicinal plant. Perhaps researchers may be able to determine more effective SMO-targeting drugs from herbal medicines in the future.
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Please cite this article as:
Han JB, Hua YQ, Chen LY, Liu LM. Advances in Smoothened-targeting therapies for pancreatic cancer: implication for drug discovery from herbal medicines. J Chin Integr Med / Zhong Xi Yi Jie He Xue Bao. 2012; 10(3): 256-263.
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