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Journal of Chinese Integrative Medicine: Volume 2, 2004   Issue 2,  Pages: 94-96

DOI: 10.3736/jcim20040205
Original Clinical Research
Effect of Xiangdan Injection on mRNA expression of endothelial vaso-active factors of patients with coronary heart disease and blood stasis
1. WU Shi-Da (Department of Cardiology, Chengdu First People's Hospital, Chengdu, Sichuan Province 610016, China )
2. WANG Jing (Department of Cardiology, Chengdu First People's Hospital, Chengdu, Sichuan Province 610016, China )
3. CHEN Shou-Chun (Chengdu Di'ao Pharmaceutical (Group) Co. Ltd., Chengdu, Sichuan Province 610041, China )
4. XU Jun-Bo (Department of Cardiology, Chengdu First People's Hospital, Chengdu, Sichuan Province 610016, China )
5. ZHENG Qiang (Department of Cardiology, Chengdu First People's Hospital, Chengdu, Sichuan Province 610016, China )
6. YAN Ya-Fei (Department of Cardiology, Chengdu First People's Hospital, Chengdu, Sichuan Province 610016, China )
7. WEN Tian-Ming (Department of Cardiology, Chengdu First People's Hospital, Chengdu, Sichuan Province 610016, China )
8. TANG Yan-Rong (Department of Cardiology, Chengdu First People's Hospital, Chengdu, Sichuan Province 610016, China )
Objective: To evaluate the effect of Xiangdan Injection on mRNA expression of the endothelial vaso-active factors of patients with coronary heart disease and blood stasis. Methods: Fifty-six patients were randomly divided into two groups: twenty-eight patients were treated according to the therapeutic guide for coronary heart disease as the control group and 28 were given the same treatment plus Xiangdan Injection as the treated group. The expressions of ET-1 and eNOS mRNA were examined with RT-PCR before experiment and ten days later. Results: The positive rate of eNOS mRNA of the treated group increased, while the positive rate of ET-1 mRNA of the treated group decreased after ten day's treatment, with significant differences as compared with that before the experiment. Xiangdan Injection up-regulated the eNOS mRNA expression and suppressed the ET-1 mRNA expression. Changes of expression were not observed in the control group. Conclusion: Xiangdan Injection improves the endothelial function of patients with coronary heart disease and blood stasis by regulating the expressions of ET-1 and eNOS mRNA.
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Please cite this article as:
Wu SD, Wang J, Chen SC, Xu JB, Zheng Q, Yan YF, Wen TM, Tang YR. Effect of Xiangdan Injection on mRNA expression of endothelial vaso-active factors of patients with coronary heart disease and blood stasis. J Chin Integr Med / Zhong Xi Yi Jie He Xue Bao. 2004; 2(2): 94-96.
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