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Journal of Integrative Medicine: Volume 12, 2014   Issue 1,  Pages: 1-6

DOI: 10.1016/S2095-4964(14)60008-X
Review
The role of central nervous system on hypoglycemia and the feasibility of the brain theory in traditional Chinese medicine on treatment of diabetes mellitus
1. Hai-li Jiang (Department of Endocrinology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China )
2. Jing-jing Niu (Department of Endocrinology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China )
3. Wei-fei Zhang (Department of Endocrinology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China )
4. Wen-jin Huang (Department of Endocrinology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China )
5. Ming-yue Zhou (Department of Endocrinology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China )
6. Wen-jun Sha (Department of Endocrinology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China )
7. Jun-yan Li (Department of Endocrinology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China )
8. Fu-feng Li (Basic Medical Department, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China )
9. Ting Zhu (Department of Gerontology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China )
10. Xin Xia (Department of Endocrinology, Shanghai East Hospital, Shanghai 200120, China )
11. Jun Zhang (Department of Police Training, Shanghai Police College, Shanghai 200137, China )
12. Yuan-dong Shen (Department of Endocrinology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China )
13. Li-gang Zhou (Department of Endocrinology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China E-mail: ligang.zhou@gmail. com)

ABSTRACT: The central nervous system (CNS) plays a key regulatory role in glucose homeostasis. In particular, the brain is important in initiating and coordinating protective counterregulatory responses when blood glucose levels fall. This may due to the metabolic dependency of the CNS on glucose, and protection of food supply to the brain. In healthy subjects, blood glucose is normally maintained within a relatively narrow range. Hypoglycemia in diabetic patients can increase the risk of complications, such as heart disease and diabetic peripheral neuropathy. The clinical research finds that the use of traditional Chinese medicine (TCM) has a positive effect on the treatment of hypoglycemia. Here the authors reviewed the current understanding of sensing and counterregulatory responses to hypoglycemia, and discuss combining traditional Chinese and Western medicine and the theory of iatrogenic hypoglycemia in diabetes treatment. Furthermore, the authors clarify the feasibility of treating hypoglycemia on the basis of TCM theory and CNS and have an insight on its clinical practice.

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Please cite this article as:
Jiang HL, Niu JJ, Zhang WF, Huang WJ, Zhou MY, Sha WJ, Li JY, Li FF, Zhu T, Xia X, Zhang J, Shen YD, Zhou LG. The role of central nervous system on hypoglycemia and the feasibility of the brain theory in traditional Chinese medicine on treatment of diabetes mellitus. J Integr Med. 2014; 12(1): 1-6.
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