Updated Wednesday, August 20, 2014
 Journal Tools
E-alerts
RSS Feed
Sample Copy
Submit a Manuscript
Contact Us
Subscription
Advertising
Thanking Peer Reviewers
 Language Polishing
Journal of Chinese Integrative Medicine: Volume 10, 2012   Issue 6,  Pages: 628-634

DOI: 10.3736/jcim20120605
Original Clinical Research
Effects of Ginkgo biloba extract in improving episodic memory of patients with mild cognitive impairment: a randomized controlled trial
1. Ming-xing Zhao (Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China )
2. Zhen-hua Dong (Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China )
3. Zhong-hai Yu (Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China )
4. Shi-yuan Xiao (Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China )
5. Ya-ming Li (Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China E-mail: E-mail: lymys@yahoo.cn)
BACKGROUND: Mild cognitive impairment is a transitional stage between normal aging and dementia. It is important in terms of recognizing memory loss in older people as well as identifying a group of individuals at high risk of developing dementia and who may benefit from preventive strategies. Ginkgo biloba extract has been shown to possess polyvalent properties, such as anti-oxidation, anti-apoptosis and anti-inflammation. Ginkgo biloba extract appears to have a neuroprotective effect against neurodegenerative diseases.
OBJECTIVE: To observe the efficacy of Ginkgo biloba leaf tablet in improving episodic memory of mild cognitive impairment.
DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: This is a multicenter, randomized, controlled trial. The authors enrolled generally healthy, ambulatory or ambulatory-aided amnestic subjects with MCI, 60 to 85 years old, who expressed a memory complaint from Huadong Hospital, seven Community Health Centers in Shanghai, and Shanghai First Welfare Institution. A total of 120 MCI patients were randomly assigned to the Ginkgo biloba leaf tablet group (treatment group, 60 cases) and control group (60 cases). The patients in the treatment group took Ginkgo biloba leaf tablets 3 times a day, 19.2 mg each dose. The control group did not receive any intelligence-promoting or vasodilator reflex treatment except some health care.
MAIN OUTCOME MEASURES: The patients were tested with nonsense picture recognition of the clinical memory scale and the logical memory test based on the Wechsler memory scale before and after treatment.
RESULTS: After 6 months of treatment, the scores of the logical memory test and nonsense picture recognition were increased significantly in the treatment group (P<0.01, P<0.05), while the scores of the two tests from the control group had no statistically significant difference (P>0.05). After treatment, the positive rate of nonsense picture recognition was 55.17% in the treatment group, which was significantly higher than that of the control group at 32.73% (P<0.05). The efficacy rate of logical memory was 58.62% in the treatment group, also higher than 38.18% in the control group (P<0.05).
CONCLUSION: Ginkgo biloba leaf tablet showed good efficacy in promoting episodic memory function in MCI patients.
Welcome to JIM! You are the number 4862 reader of this article!
Download Article:
[Full Text]      [PDF]      [Previous]      [Next]      [This Issue]
Please cite this article as:
Zhao MX, Dong ZH, Yu ZH, Xiao SY, Li YM. Effects of Ginkgo biloba extract in improving episodic memory of patients with mild cognitive impairment: a randomized controlled trial. J Chin Integr Med / Zhong Xi Yi Jie He Xue Bao. 2012; 10(6): 628-634.
References:
1Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, Ritchie K, Rossor M, Thal L, Winblad B. Current concepts in mild cognitive impairment[J].Arch Neurol, 2001, 58(12): 1985-1992.  
2Wen HB, Zhou HB. Changes in cerebral blood flow in patients with mild cognitive impairment[J].Zhongguo Lin Chuang Kang Fu, 2005, 9(37): 6-7. Chinese with abstract in English
3Xiao SY, Zhang CY, Li JY, Liu YF, Zhao MX, Dong ZH, Li YM. Clinical study on effect of Ginkgo-leaf tablet (Sitailong) in treating mild cognitive impairment[J].Zhong Cheng Yao, 2011, 33(5): 751-754. Chinese with abstract in English
4American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-Ⅳ). 4th ed[M]. Washington: American Psychiatric Association, 1994. 143-147.  
5Petersen RC, Smith GE, Waring RC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome[J].Arch Neurol, 1999, 56(3): 303-308.  
6Reisberg B, Ferris SH, de Leon MJ, Crook T. The Global Deterioration Scale for the assessment of primary degenerative dementia[J].Am J Psychiatry, 1982, 139(9): 1136-1139.  
7Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL. A new clinical scale for the staging of dementia[J].Br J Psychiatry, 1982, 140: 566-572.  
8The Cooperation Group for the Construction of “the Clinical Memory Test”. The construction of “the clinical memory test”[J].Xin Li Xue Bao, 1986, (1): 100-108. Chinese with abstract in English
9Yu H, Guo QH, Hong Z, Lü CZ. Detecting of logical memory impairment in mild Alzheimer’s disease[J].Shen Jing Ji Bing Yu Jing Shen Wei Sheng, 2005, 5(2): 89-91. Chinese with abstract in English
10Panza F, Capurso C, D’Introno A, Colacicco AM, Capurso A, Solfrizzi V, Bennett. Mild cognitive impairment: risk of Alzheimer disease and rate of cognitive decline[J].Neurology, 2007, 68(12): 964-965.  
11Li BR, Bi GN, Qiu YD, Shi SL. Clinical study on cognition of mild cognitive impairment[J].Guangxi Yi Xue, 2007, 29(5): 627-628. Chinese with abstract in English
12Kandel ER, Kupfermann L, Iversen S. Learning and Memory. In: Kandel ER, Schwartz JH, Jessell TM. Principles of neural science. 4th ed[M]. Columbia: McGraw-Hill Companies Inc, 2000. 1231-1233.  
13Wang W, Wang LN, Xie HG, Zhang XH. A follow-up study on the memorial function of the patients with mild cognitive impairment[J].Jie Fang Jun Yi Xue Za Zhi, 2006, 31(5): 379-381. Chinese with abstract in English
14Celsis P. Age-related cognitive decline, mild cognitive impairment or preclinical Alzheimer’s disease? Ann Med. 2000; 32(1): 6-14.
15Wolf H, Grunwald M, Kruggel F, Riedel-Heller SG, Angerhfer S, Hojjatoleslami A, Hensel A, Arendt T, Gertz H. Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly[J].Neurobiol Aging, 2001, 22(2): 177-186.  
16Gao P, Qin SS, Liu YH, Cai XJ, Yu ZG, Han LJ. Study on the correlation between cognitive functions and regional blood flow in Alzheimer disease and mild cognitive impairment[J].Zhongguo Shen Jing Mian Yi Xue He Shen Jing Bing Xue Za Zhi, 2006, 13(4): 205-208. Chinese with abstract in English
17Xu JP, Li L, Sun LS. Effects of ginkgolide on cerebral blood flow in dogs[J]. J Chin Integr Med, 2005, 3(1): 50-53. Chinese with abstract in English
18Bao YM, Liu AH, Zhang ZX, Li Y, Wang XY. Effects of Ginkgo biloba extract 50 preconditioning on contents of inflammation-related cytokines in myocardium of rats with ischemia reperfusion injury[J]. J Chin Integr Med, 2010, 8(4): 373-378. Chinese with abstract in English
19Erbil G, Ozbal S, Sonmez U, Pekcetin C, Tugyan K, Bagriyanik A, Ozogul C. Neuroprotective effects of selenium and Ginkgo biloba extract (EGb761) against ischemia and reperfusion injury in rat brain[J].Neurosciences (Riyadh), 2008, 13(3): 233-238.  
20Shen J, Lee W, Gu Y, Tong Y, Fung PC, Tong L. Ginkgo biloba extract (EGb761) inhibits mitochondria-dependent caspase pathway and prevents apoptosis in hypoxia-reoxygenated cardiomyocytes[J].Chin Med, 2011, 6: 8.  
21Shi C, Yao Z, Xu J, Yew DT. Effects of Gingko extract (EGb761) on oxidative damage under different conditions of serum supply[J].J Bioenerg Biomembr, 2009, 41(1): 61-69.  
22Barnes PM, Bloom B, Nahin RL. Complementary and alternative medicine use among adults and children: United States, 2007[J].Natl Health Stat Report, 2008, 12: 1-23.  
23Zhu ZF, Ji K, Han BJ, Feng DH. Clinical study on effect of Aricept combined with Ginkgo biloba in treating vascular cognitive impairment[J].Lin Chuang Xin Shen Ji Bing Za Zhi, 2007, 13(6): 549-550. Chinese
24Feng YQ, Wang JH, Zhao DW, Qi YC, Gao JS, Li ZL, Liu GF. Donepezil alone vs Donepezil combined with Gingko biloba extract in treatment of Alzheimer disease[J].Zhongguo Xin Yao Yu Lin Chuang Za Zhi, 2004, 11(11): 792-795. Chinese with abstract in English
25Yan L, Wang SS, Yang XT, Wang H. Effect of Gingko biloba Tablet in improving early postoperative cognitive function in patients with senile dementia[J].Zhongguo Lao Nian Xue Za Zhi, 2002, 22(3): 175-177. Chinese
 Home | Current Issue | Past Issues | SearchRSS
Copyright © 2013-2015 by JIM Editorial Office. All rights reserved. ISSN 2095-4964; CN 31-2083/R. 沪ICP备110264号