三生化痰汤在非小细胞肺癌化疗中的应用

doi:10.3736/jcim20040208

Abstract

：Objective: To observe the clinical effect of Chinese medicine Sansheng Huatan Decoction combined with chemotherapy in treating advanced primary non-small-cell lung cancer and to evaluated the effect of Sansheng Huatan Decoction increasing clinical effect and decreasing toxicity in chemotherapy for non-small-cell lung cancer. Methods: One hundred and sixty patients of advanced primary non-small-cell lung cancer proved by pathological examination were randomized into two groups. The treatment group was treated with Sansheng Huatan Decoction and chemotherapy, and the control group was treated only with chemotherapy. The clinic effect, life quality, natural killer (NK) activities, liver and kidney functions, and blood routine test of the 2 groups were evaluated. Results: The clinical effective rates of the treatment and control groups were 56.7% and 48.2% respectively, and there was no statistic significance (P>0.10). The life quality, NK activities and blood routine test of the treatment group were better than those of the control group. Conclusion: Sansheng Huatan Decoction combined with chemotherapy is a better treatment for non small cell lung cancer as compared with chemotherapy.

Key words: Sansheng Huatan Decoction, non-small-cell lung cancer, integrated traditional Chinese with western medicine

CLC Number:

R734.2

Wei-ming Fang, Wei-ping Wang, Bing-wei Yan, Jian-yuan Zhou. Treatment of non-small-cell lung cancer with chemotherapy and Sansheng Huatan Decoction. Journal of Chinese Integrative Medicine, 2004, 2(2): 103-105.

/ / Recommend

Add to citation manager EndNote| Reference Manager|ProCite|BibTeX|RefWorks

URL: http://www.jcimjournal.com/EN/10.3736/jcim20040208

http://www.jcimjournal.com/EN/Y2004/V2/I2/103

trendmd

Figures/Tables 3

Tab 1

Tab 2

Tab 3

References 4

[1]	上海市肿瘤研究所流行病学研究室.1999年上海市市区恶性肿瘤发病率[J].肿瘤,2002,5(3):259 doi: 10.3781/j.issn.1000-7431.2002.03.037
[2]	韩明权, 苏晋梅, 黄海茵, 等.序贯化放疗结合中药治疗54例晚期非小细胞肺癌患者的预后分析[J].中西医结合学报,2003,1(3):195-198
	Han MQ, Su JM, Huang HY, et al.Prognostic analysis of advanced non small cell lung cancer treated by sequential chemo-radiation therapy cimbined with tradtional Chinese medicine: A report of 54 cases[J].Zhong Xi Yi Jie He Xue Bao,2003,1(3):195-198
[3]	秦笃祥, 李道堂.临床胸部肿瘤学(第1版)[M].济南: 山东科学技术出版社,1995,(第1版):257-258
[4]	中华人民共和国卫生部医政司编.中国常见恶性肿瘤诊疗规范(第9分册)(第1版)[M].北京: 北京医科大学、中国协和医科大学联合出版社,1991,(第1版):10-13

Related Articles 15

[1]	Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228.
[2]	Gui-ying Yan, Zhen-ye Xu, Hai-bin Deng, Zhi-yong Wan, Lei Zhang, Jiao-yu Zhu. Effects of chemotherapy combined with Chinese herbal medicine Kangliu Zengxiao Decoction on tumor markers of patients with advanced non-small-cell lung cancer: A randomized, controlled trial. Journal of Chinese Integrative Medicine, 2011, 9(5): 525-530.
[3]	Li-xin Lang, Xiao-bo Wang, Wei Hou. Successful treatment of adult idiopathic pulmonary hemosiderosis with integrated traditional Chinese and Western medicine: A report of one case. Journal of Chinese Integrative Medicine, 2011, 9(5): 531-532.
[4]	the Project Group for Demonstration Study of Syndrome Differentiation Protocol Effect Evaluation of Acute Ischemic Stroke, Yan Huang, Jian-wen Guo. Outcome and safety assessment of an herbal medicine treatment protocol for yin pattern of acute ischemic stroke. Journal of Chinese Integrative Medicine, 2010, 8(5): 417-426.
[5]	Hao Li , Long-tao Liu, Wen-ming Zhao, Jian-gang Liu, Ming-jiang Yao, Yong-xiang Han, Yan-peng Shen, Xing-dong Liu, Li Liu, Xue-mei Wang, Lin-lin Cai, Jie Guan. Traditional Chinese versus integrative treatment in elderly patients with isolated systolic hypertension: A multicenter, randomized, double-blind controlled trial. Journal of Chinese Integrative Medicine, 2010, 8(5): 410-416.
[6]	Ni-da Cao, Ai-guang Zhao, Jin-kun Yang. Survival time of advanced gastric cancer patients treated with integrated traditional Chinese and Western medicine therapy. Journal of Chinese Integrative Medicine, 2010, 8(2): 116-120.
[7]	Zhi-zhen Liu, Zong-yang Yu, Xue-nong Ouyang, Xi-hu Dai, Xi Chen, Zhong-quan Zhao, Wen-wu Wang, Jie Li, Hua Tu, Lei Ye, Yan Yan. Effects of Feitai Capsule on quality of life in patients with advanced non-small-cell lung cancer: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2009, 7(7): 611-615.
[8]	Wen-hua Ma , Kai-nan Duan, Min Feng, Bin She, Yan Chen, Rui-ming Zhang. Aidi Injection as an adjunct therapy for non-small cell lung cancer: A systematic review. Journal of Chinese Integrative Medicine, 2009, 7(4): 315-324.
[9]	Song-lin Cheng, Xiao-yun Liu, Wei-xi Zhang. Integrated traditional Chinese and Western medicine in treating 31 cases of myasthenia gravis. Journal of Chinese Integrative Medicine, 2008, 6(9): 964-967.
[10]	Yi-fei Wang, Bo-hua Li, Ming Zhang, Wen-bin Xu, Rong Zhou, Min Zhou. Stage-based treatment of gouty arthritis by combination therapy of traditional Chinese and Western medicines: a randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(6): 576-580.
[11]	Yi-ping Chen. Clinical study of integrative medicine in treatment of nephropathy: strategy and innovation. Journal of Chinese Integrative Medicine, 2008, 6(5): 446-448.
[12]	Yan-hui Sun, Yong-qing Cao, Jin-gen Lu, Xiu-tian Guo. Clinical observation of incision and drainage with ultracision-harmonic scalpel and thread-drawing in children with anal fistula: a report of 21 cases. Journal of Chinese Integrative Medicine, 2008, 6(4): 414-415.
[13]	Zhu-yi Zhang, Shi-qing Yu, Li-yun Miao, Xiao-ying Huang, Xiao-ping Zhang, Yu-ping Zhu, Xiao-hong Xia, Dan-qi Li. Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small cell lung cancer: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(2): 134-138.
[14]	Chi-shing Cho. Progress of integrative medicine, human papillomavirus vaccine and molecular targeted therapy for cervical cancer. Journal of Chinese Integrative Medicine, 2008, 6(2): 203-208.
[15]	Hong-qiang Wei, Zong-wen Huang, Hui Li. Early treatment with integrated traditional Chinese and Western medicine in adhesive intestinal obstruction. Journal of Chinese Integrative Medicine, 2008, 6(10): 1062-1064.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

Comments

Recommended 10

[1]	Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2]	Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3]	Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4]	Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5]	. Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6]	Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7]	Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8]	Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9]	Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10]	Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228

Group	Clinical stage	n	Complete remission	Partial remission	Stable disease	Progressive disease
Treatment group
	II	3	3( 2.9)	0	0	0
	IIIa	24	5( 4.8)	16(15.4)	2(1.9)	1(0.9)
	IIIb	33	5( 4.8)	19(18.2)	6(5.8)	3(2.9)
	IV	44	0	11(10.6)	28(26.9)	5(4.8)
	Total	104	13(12.5)	46(44.2)	36(34.6)	9(8.7)
Control group
	II	1	1(1.8)	0	0	0
	IIIa	14	3(5.3)	7(12.5)	3( 5.4)	1(1.8)
	IIIb	20	2(3.5)	9(16.2)	7(12.5)	2(3.5)
	IV	21	0	5(8.9)	13(23.2)	3(5.3)
	Total	56	6(10.6)	21(37.6)	23(41.2)	6(10.6)

Group	Gradation of toxicity	Leukocyte	Platelet	Hemoglobin
Treatment group（n=104）
	0	16(15.3)	20(19.2)	42(40.4)
	I	39(37.5)	32(30.8)	37(35.6)
	II	26(25.0)	48(46.2)	22(21.1)
	III	15(14.5)	2(1.9)	2(1.9)
	IV	8(7.7)	2(1.9)	1(1.0)
Control group（n=56）
	0	7(12.5)	16(28.5)	16(28.5)
	I	9(16.1)	14(25.0)	22(39.2)
	II	16(28.5)	16(28.6)	13(23.2)
	III	18(32.2)	9(16.1)	4(7.2)
	IV	6(10.7)	1(1.8)	1(1.8)

Group	n	TBIL（μmol/L）	ALT（U/L）	BUN（mmol/L）	Cr（μmol/L）
Treatment group
Before treatment	104	16.9±8.9	52.6±6.7	5.2±1.9	95±28
After treatment	104	15.4±7.6	51.7±10.5	5.4±2.3	104±34
Control group
Before treatment	56	15.9±6.9	51.9±23.3	5.3±1.7	89±36
After treatment	56	19.7±7.2	69.4±29.4	6.2±2.1	114±32

Treatment of non-small-cell lung cancer with chemotherapy and Sansheng Huatan Decoction

RichHTML

PDF (PC)

Like