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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (2): 203-208.doi: 10.3736/jcim20080220

• Literature Review • Previous Articles     Next Articles

Progress of integrative medicine, human papillomavirus vaccine and molecular targeted therapy for cervical cancer

Chi-shing Cho()   

  1. Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China
  • Received:2007-08-17 Online:2008-02-20 Published:2008-02-15
  • Contact: CHO Chi-shing

Key words: cervical cancer, human papillomavirus, vaccines, diagnosis, therapy, integrated Chinese traditional and Western medicine therapy

CLC Number: 

  • R737.3
[1] Feeley C . Advances in cervical cancer screening and human papillomavirus vaccines. J Br Menopause Soc. 2006; 12(1):19-23.
doi: 10.1258/136218006775997252 pmid: 16513018
[2] Parkin DM, Bray F, Ferlay J , et al. Global cancer statistics, 2002. CA Cancer J Clin. 2005; 55(2):74-108.
[3] Doorbar J . Molecular biology of human papillomavirus infection and cervical cancer. Clin Sci (Lond). 2006; 110(5):525-541.
doi: 10.1042/CS20050369
[4] Martin CM, Astbury K , O'Leary JJ. Molecular profiling of cervical neoplasia. Expert Rev Mol Diagn. 2006 ; 6(2):217-229.
doi: 10.1586/14737159.6.2.217 pmid: 16512781
[5] Haverkos HW . Multifactorial etiology of cervical cancer: a hypothesis. MedGenMed. 2005; 7(4) : 57.
pmid: 16614679
[6] Danaei G, Vander Hoorn S, Lopez AD , et al. Causes of cancer in the world : comparative risk assessment of nine behavioural and environmental risk factors. Lancet. 2005; 366(9499):1784-1793.
doi: 10.1016/S0140-6736(05)67725-2
[7] International Collaboration of Epidemiological Studies of Cervical Cancer. Cervical carcinoma and reproductive factors : Collaborative reanalysis of individual data on 16, 563 women with cervical carcinoma and 33, 542 women without cervical carcinoma from 25 epidemiological studies. Int J Cancer. 2006; 119(5):1108-1124.
[8] Rieck G, Fiander A . The effect of lifestyle factors on gynaecological cancer. Best Pract Res Clin Obstet Gynaecol. 2006; 20(2):227-251.
doi: 10.1016/j.bpobgyn.2005.10.010 pmid: 16543119
[9] Valdespino VM, Valdespino VE . Cervical cancer screening : state of the art. Curr Opin Obstet Gynecol. 2006; 18(1):35-40.
doi: 10.1097/01.gco.0000192971.59943.89 pmid: 16493258
[10] Zeferino LC, Derchain SF . Cervical cancer in the developing world. Best Pract Res Clin Obstet Gynaecol. 2006; 20(3):339-354.
doi: 10.1016/j.bpobgyn.2006.01.018 pmid: 11577044
[11] Calloway C, Jorgensen CM, Saraiya M , et al. A content analysis of news coverage of the HPV vaccine by U. S. newspapers,January 2002-June 2005. J Womens Health (Larchmt). 2006; 15(7):803-809.
doi: 10.1089/jwh.2006.15.803
[12] Ljubojevic S . The human papillomavirus vaccines. Acta Dermatovenerol Croat. 2006; 14(3):208.
[13] Hanna E, Bachmann G . HPV vaccination with Garda- sil : a breakthrough in womens health. Expert Opin Biol Ther. 2006; 6(11):1223-1227.
doi: 10.1517/14712598.6.11.1223
[14] McLemore MR . Gardasil: Introducing the new human papillomavirus vaccine. Clin J Oncol Nurs. 2006; 10(5):559-560.
doi: 10.1188/06.CJON.559-560 pmid: 17063609
[15] HPV vaccine fights cervical cancer. CA Cancer J Clin. 2006; 56(5):249-250.
[16] Prandi S, Beccati D, De Aloysio G , et al. Applicability of the Bethesda System 2001 to a public health setting. Cancer. 2006; 108(5):271-276.
doi: 10.1002/cncr.22167 pmid: 16948127
[17] Long HJ 3rd, Laack NN, Gostout BS . Prevention, diagnosis ,and treatment of cervical cancer. Mayo Clin Proc. 2007; 82(12):1566-1574.
doi: 10.1016/S0025-6196(11)61104-X pmid: 18053467
[18] Kalliala I, Nieminen P, Dyba T , et al. Cancer free survival after CIN treatment: comparisons of treatment methods and histology. Gynecol Oncol. 2007; 105(1):228-233.
doi: 10.1016/j.ygyno.2006.12.028 pmid: 17289128
[19] Canis M, Farina M, Jardon K , et al. Laparoscopy and gynecologic cancer in 2005. J Gynecol Obstet Biol Reprod (Paris). 2006; 35(2):117-135.
doi: 10.1016/S0368-2315(06)76386-4
[20] Cuzick J, Clavel C, Petry KU , et al. Overview of the European and North American studies on HPV testing in primary cervical cancer screening. Int J Cancer. 2006; 119(5):1095-1101.
[21] McCaffery K, Waller J, Nazroo J , et al. Social and psychological impact of HPV testing in cervical screening: a qualitative study. Sex Transm Infect. 2006; 82(2):169-174.
doi: 10.1136/sti.2005.016436 pmid: 16581749
[22] Zheng Y, Peng ZL, Lou JY , et al. Detection of physical status of human papillomavirus 16 in cervical cancer tissue and SiHa cell line by multiplex real-time polymerase chain reaction. Ai Zheng. 2006; 25(3):373-377. Chinese with abstract in English.
doi: 10.3321/j.issn:1000-467X.2006.03.024
郑莹, 彭芝兰, 楼江燕 , 等. 多重实时PCR对宫颈癌组织及SiHa细胞株HPV-16病毒存在状态的检测.癌症. 2006; 25(3):373-377.
doi: 10.3321/j.issn:1000-467X.2006.03.024
[23] Dimopoulos JC, Schard G, Berger D , et al. Systematic evaluation of MRI findings in different stages of treatment of cervical cancer: Potential of MRI on delineation of target, pathoanatomic structures, and organs at risk. Int J Radiat Oncol Biol Phys. 2006; 64(5):1380-1388.
[24] Chung HH, Kim SK, Kim TH , et al. Clinical impact of FDG-PET imaging in post-therapy surveillance of uterine cervical cancer: From diagnosis to prognosis. Gynecol Oncol. 2006; 103(1):165-170.
doi: 10.1016/j.ygyno.2006.02.016
[25] Falkenberg E, Kim RY, Meleth S , et al. Low-dose-rate vs. high-dose-rate intracavitary brachytherapy for carcinoma of the cervix: The University of Alabama at Birmingham (UAB) experience. Brachytherapy. 2006 ; 5(1):49-55.
doi: 10.1016/j.brachy.2005.12.001
[26] Gerszten K, Colonello K, Heron DE , et al. Feasibility of concurrent cisplatin and extended field radiation therapy (EFRT) using intensity-modulated radiotherapy (IMRT) for carcinoma of the cervix. Gynecol Oncol. 2006; 102(2):182-188.
doi: 10.1016/j.ygyno.2005.12.044
[27] Nakano T, Suzuki Y, Ohno T , et al. Carbon beam therapy overcomes the radiation resistance of uterine cervical cancer originating from hypoxia. Clin Cancer Res. 2006; 12(7 parti):2185-2190.
doi: 10.1158/1078-0432.CCR-05-1907
[28] Lee KH, Yim EK, Kim CJ , et al. Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005; 98(1) : 45-53.
doi: 10.1016/j.ygyno.2005.04.010 pmid: 15907983
[29] Ohno T, Kato S, Wakatsuki M , et al. Incidence and temporal pattern of anorexia,diarrhea, weight loss, and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin: Comparison with radiation therapy alone. Gynecol Oncol. 2006; 103(1):94-99.
doi: 10.1016/j.ygyno.2006.01.048
[30] Potter R, Dimopoulos J, Bachtiary B , et al. 3D conformal HDR-brachy- and external beam therapy plus simultaneous cisplatin for high-risk cervical cancer: Clinical experience with 3 year follow-up. Radiother Oncol. 2006; 79(1):80-86.
doi: 10.1016/j.radonc.2006.01.007
[31] Tanaka T, Bai T, Yukawa K , et al. Optimal combination chemotherapy and chemoradiotherapy with etopo- side for advanced cervical squamous cancer cells in vitro. Oncol Rep. 2006; 15(4):939-947.
[32] Wong YF, Selvanayagam ZE, Wei N , et al. Expression genomics of cervical cancer: molecular classification and prediction of radiotherapy response by DNA microarray. Clin Cancer Res. 2003; 9(15):5486-5492.
[33] Zhang Z, Huettner PC, Nguyen L , et al. Aberrant promoter methylation and silencing of the FOU2F3 gene in cervical cancer. Oncogene. 2006; 25(39) : 5436-5445.
doi: 10.1038/sj.onc.1209530 pmid: 16607278
[34] Huang FY, Chiu PM, Tam KF , et al. Semi-quantitative fluorescent PCR analysis identifies PRKAA1 on chromosome 5 as a potential candidate cancer gene of cervical cancer. Gynecol Oncol. 2006; 103(1):219-225.
doi: 10.1016/j.ygyno.2006.02.028
[35] Ueda M, Terai Y, Kanda K , et al. Fas gene promoter- 670 polymorphism in gynecological cancer. Int J Gynecol Cancer. 2006; 16 Suppl 1: 179-182.
doi: 10.1111/j.1525-1438.2006.00505.x pmid: 16515587
[36] Yim EK, Park JS . Role of proteomics in translational research in cervical cancer. Expert Rev Proteomics. 2006; 3(1):21-36.
doi: 10.1586/14789450.3.1.21 pmid: 16445348
[37] Feng YH, Li X , Wang et al. A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization. J Biol Chem. 2006; 281(25):17228-17237.
doi: 10.1074/jbc.M602999200
[38] Bae SM, Lee CH, Cho YL , et al. Two-dimensional gel analysis of protein expression profile in squamous cervical cancer patients. Gynecol Oncol. 2005; 99(1):26-35.
doi: 10.1016/j.ygyno.2005.05.041 pmid: 16051329
[39] Kitkumthorn N, Yanatatsanajit P, Kiatpongsan S , et al. Cyclin Al promoter hypermethylation in human papillomavirus-associated cervical cancer. BMC Cancer. 2006; 6:55.
doi: 10.1186/1471-2407-6-55 pmid: 1435765
[40] Zhao M, Kim YT, Yoon BS , et al. Expression profiling of cyclin B1 and D1 in cervical carcinoma. Exp Oncol. 2006; 28(1):44-48.
doi: 10.1016/S0168-8278(01)00079-4 pmid: 16614707
[41] Li HY, Xu Q, Zhu T, et al. Expression and clinical significance of Pinl and Cyclin D1 in cervical cancer cell lines and cervical epithelial tissues. Ai Zheng. 2006; 25(3):367-372. Chinese with abstract in Engliah.
doi: 10.3969/j.issn.1000-467X.2006.03.023
李红雨, 徐茜, 朱涛 , 等. 宫颈癌细胞株和宫颈上皮组织中Pinl和Cyclin D1的表达及临床意义.癌症. 2006; 25(3):367-372.
doi: 10.3969/j.issn.1000-467X.2006.03.023
[42] Malinowski DP . Molecular diagnostic assays for cervical neoplasia: emerging markers for the detection of high- grade cervical disease. Biotechniques. 2005
( Suppl):17-23.
[43] Gupta N, Martin PM, Miyauchi S , et al. Down-regulation of BCRP/ABCG2 in colorectal and cervical cancer. Biochem Biophys Res Commun. 2006; 343(2):571-577.
doi: 10.1016/j.bbrc.2006.02.172 pmid: 16554028
[44] Wu SH, Zhang J, Li Y , et al. Expression of ETV5 and MMP-7 in early stage cervical squamous cell carcinoma and its role in lymphatic metastasis. Ai Zheng. 2006; 25(3):315-319. Chinese with abstract in English.
吴素慧, 张静, 李颖 , 等. ETV5对MMP-7在早期宫颈癌组织中的表达及其在转移中的作用.癌症. 2006; 25(3):315-319.
[45] Branca M, Ciotti M, Giorgi C , et al. Matrix metallo- proteinase-2 (MMP-2) and its tissue inhibitor (TIMP- 2) are prognostic factors in cervical cancer, related to invasive disease but not to high-risk human papillomavirus (HPV) or virus persistence after treatment of CIN. Anticancer Res. 2006; 26(2B):1543-1556.
[46] Branca M, Giorgi C, Ciotti M , et al. Down-regulated nucleoside diphosphate kinase nm23_Hl expression is unrelated to high-risk human papillomavirus but associated with progression of cervical intraepithelial neoplasia and unfavourable prognosis in cervical cancer. J Clin Pathol. 2006; 59(10):1044-1051.
[47] Divya CS, Pillai MR . Antitumor action of curcumin in human papillomavirus associated cells involves downreg- ulation of viral oncogenes, prevention of NF-κB and AP- 1 translocation, and modulation of apoptosis. MolCar- cinog. 2006; 45(5):320-332.
[48] Kim SH, Hwang Cl, Juhnn YS , et al. GADD153 mediates celecoxib-induced apoptosis in cervical cancer cells. Carcinogenesis. 2007; 28(1) : 223-231.
doi: 10.1093/carcin/bgl227 pmid: 3222217166886
[49] Putral LN, Bywater MJ, Gu W , et al. RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin. Mol Pharmacol. 2005; 68(5):1311-1319.
doi: 10.1124/mol.105.014191
[50] Niu XY, Peng ZL, Duan WQ, et al. Inhibition of HPVI6 E6 oncogene in cervical cancer by RNA interference. Sichuan Da Xue Xue Bao ( Yi Xue Ban ). 2006; 37(1):14-18. Chinese with abstract in English.
牛晓宇, 彭芝兰, 段伟强 , 等. RNA干涉抑制宫颈癌 HPV16E6基因的研究. 四川大学学报(医学版). 2006; 37(1):14-18.
[51] Tang S, Tao M , McCoy JP Jr, et al. Short-term induction and long-term suppression of HPV16 oncogene silencing by RNA interference in cervical cancer cells. Oncogene. 2006; 25(14):2094-2104.
doi: 10.1038/sj.onc.1209244
[52] Vogt M, Butz K, Dymalla S , et al. Inhibition of Bax activity is crucial for the antiapoptotic function of the human papillomavirus E6 oncoprotein. Oncogene. 2006; 25(29):4009-4015.
doi: 10.1038/sj.onc.1209429
[53] Li W, Jian W, Xiaoping X , et al. Enhanced radiation- mediated cell killing of human cervical cancer cells by small interference RNA silencing of ataxia telangiectasia-mutated protein. Int J Gynecol Cancer. 2006; 16(4):1620-1630.
[54] Rossi A, Ciafre S, Balsamo M , et al. Targeting the heat shock factor 1 by RNA interference: a potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer. Cancer Res. 2006; 66(15) : 7678-7685.
doi: 10.1158/0008-5472.CAN-05-4282
[55] Calin GA, Croce CM . MicroRNA signatures in human cancers. Nat Rev Cancer. 2006; 6(11):857-866.
doi: 10.1038/nrc1997 pmid: 17060945
[56] Cho WC . OncomiRs: the discovery and progress of microRNAs in cancers. Mol Cancer. 2007; 6(1) : 60.
doi: 10.1186/1476-4598-6-60
[57] Lui WO, Pourmand N, Patterson BK , et al. Patterns of known and novel small RNAs in human cervical cancer. Cancer Res. 2007; 67(13):6031-6043.
doi: 10.1158/0008-5472.CAN-06-0561
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