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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (6): 421-425.doi: 10.3736/jcim20050601

• Expert Forum •     Next Articles

Evaluating the effects of acupuncture on knee osteoarthritis: A stepwise approach to research, University of Maryland experience

Li-xing Lao,Brian Berman   

  1. Center for Integrative Medicine, School of Medicine, University of Maryland, Third Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, Maryland 21207, USA
  • Received:2005-08-16 Online:2005-11-20 Published:2005-11-20
  • Contact: Lixing Lao, Ph.D. E-mail:llao@compmed.umm.edu

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Conventional treatments for osteoarthritis (OA), the most common form of arthritis, are associated with unpleasant adverse effects and often ineffective. Acupuncture and traditional Chinese medicine (TCM) have been used for thousands of years to treat pain and other dysfunctions. However, the scientific evidence on the efficacy of acupuncture and TCM is equivocal, and adapting the Western biomedical model to assess them is a great challenge. By adopting a systematic, step-by-step approach, the research team at the University of Maryland has been carefully evaluating the effectiveness of acupuncture on knee OA over the past 10 years. Their successful experience may be a useful model for future acupuncture and TCM research.

Key words: Osteoarthritis, Knee, Randomized controlled clinical trials, Outcome assess, Acupuncture therapy

CLC Number: 

  • R245.31

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类型 主要特点
Ⅰ期 药物作用、合适剂量、安全性的预初研究。采用典型的非随机化的人体初步试验,通常不设对照组。
Ⅱ期 疗效评价的预初研究,进一步研究药物的剂量和安全性。试验可以是随机化的。比Ⅰ期的研究规模大,
但总体来看还是小规模的。
Ⅲ期 评估剂量效应,评价长期使用的安全性和有效性。试验是随机化的。治疗必须显示良好的风险/效益比。

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