急性脑缺血大鼠模型血瘀证舌象表现的评价方法 及其与血液流变学的关系

doi:10.3736/jcim20080114

Abstract

Objective:To study the tongue tissue blood oxygen saturation measurement for evaluating tongue manifestation of blood stasis syndrome, and to explore its correlation with blood rheological disorder in a rat model of acute transient brain ischemia.

Methods:Twentyeight SD rats were randomly divided into shamoperated group and ischemia group. Middle cerebral artery occlusion was induced by thread in rats of the ischemia group. Tongue tissue blood oxygen saturation, neurological severity score and the changes of blood viscosity, red blood cell deformity, thrombin time and fibrinogen in the rats were measured after 24hour reperfusion.

Results:Blood viscosity and the content of fibrinogen in the ischemia group were significantly higher than those in the shamoperated group. Red blood cell deformity, thrombin time and tongue tissue blood oxygen saturation in the ischemia group were decreased as compared with the shamoperated group. There was a positive correlation between red blood cell deformity and tongue tissue blood oxygen saturation.

Conclusion:Tongue tissue blood oxygen saturation is a good measurement for evaluating blood stasis in a rat model of focal cerebral ischemia, and this model can be used as a rat model of stroke with blood stasis syndrome.

Key words: blood stasis, brain ischemia, reperfusion, hemorheology, rats

CLC Number:

R743.31

Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76.

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Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia

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