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Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (6): 551-555.doi: 10.3736/jcim20060601

• Editorial •     Next Articles

Guideline for the diagnosis and treatment of liver fibrosis with integrative medicine

Chinese Association of Integrative Medicine, Liver Disease Committee   

  • Online:2006-11-30 Published:2006-11-15

Key words: Liver fibrosis, Integrative medicine, Diagnosis, treatment, Guideline

CLC Number: 

  • R2-031

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证据等级 定义
随机对照临床试验
Ⅱ-1 有对照但非随机的临床试验
Ⅱ-2 队列研究或病例对照研究
Ⅱ-3 多时间点病例系列分析,结果明显的非对照试验
专家观点及描述性流行病学研究

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炎症活动度 纤维化程度
级(G) 汇管区及周围 小叶内 期(S) 纤维化程度
0 无炎症 无炎症 0
1 汇管区炎症 变性及少数点状坏死 1 汇管区纤维化扩大,局限窦周及小叶内纤维化
2 轻度PN或嗜酸小体 变性,点、灶状坏死 2 汇管区周围纤维化,纤维间隔形成,小叶结构保留
3 中度PN 融合坏死或见BN 3 纤维间隔伴小叶结构紊乱,无肝硬化
4 重度PN BN广泛,累及多个小叶(多小叶坏死) 4 早期肝硬化
[1] Liaw YF, Tai DI, Chu CM , et al. The development of cirrhosis in patients with chronic type B hepatitis: a prospective study[J]. Hepatology, 1988,8(3):493-496
[2] Hsu YS, Chien RN, Yeh CT , et al. Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B[J]. Hepatology, 2002,35(6):1522-1527
doi: 10.1053/jhep.2002.33638 pmid: 12029639
[3] 巫贵成, 周卫平, 赵有蓉 , 等. 慢性乙型肝炎自然史的研究[J]. 中华肝脏病杂志, 2002,10(1):46-48
[4] 中华肝脏病学会肝纤维化学组. 肝纤维化诊断及疗效评估共识[J]. 中华肝脏病杂志, 2002,10(5):327-328
[5] Knodell RG, Ishak KG, Black WC , et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis[J]. Hepatology, 1981,1(5):431-435
[6] Ishak KG . Pathologic features of chronic hepatitis. A review and update[J]. Am J Clin Patho1, 2000,113(1):40-55
[7] Scheuer PJ, Standish RA , Dhillon AP.Scoring of chronic hepatitis[J].Clin Liver Dis, 2002, 6(2):335-347, ⅴ-ⅵ
[8] Chevallier M, Guerret S, Chossegros P , et al. A histological semiquantitative scoring system for evaluation of hepatic fibrosis in needle liver biopsy specimens: comparison with morphometric studies[J]. Hepatology, 1994,20(2):349-355
[9] 上海市肝纤维化课题协作组. 肝纤维化的CT、MR诊断初步探讨[J]. 上海医学, 2002,25(4):210-213
doi: 10.3969/j.issn.0253-9934.2002.04.005
[10] Bissell DM . Assessing fibrosis without a liver biopsy: are we there yet?[J]. Gastroenterology, 2004,127(6):1847-1849
doi: 10.1053/j.gastro.2004.10.012 pmid: 15578524
[11] Rosenberg WM, Voelker M, Thiel R , et al. Serum markers detect the presence of liver fibrosis: a cohort study[J]. Gastroenterology, 2004,127(6):1704-1713
[12] Kelleher TB, Mehta SH, Bhaskar R , et al. Prediction of hepatic fibrosis in HIV/HCV co-infected patients using serum fibrosis markers: The SHASTA index[J]. J Hepatol, 2005,43(1):78-84
[13] Zeng MD, Lu LG, Mao YM , et al. Prediction of significant fibrosis in HBeAg-positive patients with chronic hepatitis B by a noninvasive model[J]. Hepatology, 2005,42(6):1437-1445
[14] 曾民德, 陆伦根, 苏益民 . 肝纤维化的诊断方法及其评估(下)[J]. 肝脏, 2006,11(3):181-183
doi: 10.3969/j.issn.1008-1704.2006.02.011
[15] 张文胜, 王宝恩, 王泰龄 , 等. 慢性乙型肝炎肝纤维化无创性诊断模型的建立[J]. 中华肝脏病杂志, 2006,14(3):169-173
doi: 10.3760/j.issn:1007-3418.2006.03.004
[16] 中华医学会肝病学分会感染病学分会. 慢性乙型肝炎防治指南[J]. 中华肝脏病杂志, 2005,13(12):881-891
doi: 10.3969/j.issn.1008-7125.2006.10.010
[17] 中华医学会肝病学分会, 中华医学会传染病与寄生虫病学分会. 丙型肝炎防治指南[J]. 中华肝脏病杂志, 2004,12(4):194-198
[18] 中华医学会肝病学分会脂肪肝和酒精性肝病学组. 酒精性肝病诊疗指南[J]. 中华肝脏病杂志, 2006,14(3):164-166
doi: 10.3969/j.issn.1008-7125.2010.10.011
[19] 中华医学会肝病学分会脂肪肝和酒精性肝病学组. 非酒精性脂肪性肝病诊疗指南[J]. 中华肝脏病杂志, 2006,14(3):161-163
doi: 10.3969/j.issn.1008-1704.2006.01.032
[20] 中华人民共和国国家标准.UDC-GB15977. 日本血吸虫病诊断标准和处理标准. 1995.
[21] Liu P, Hu YY, Liu C , et al. Multicenter clinical study on Fuzhenghuayu capsule against liver fibrosis due to chronic hepatitis B[J]. World J Gastroenterol, 2005,11(19):2892-2899
[22] 周光德, 李文淑, 赵景民 , 等. 复方鳖甲软肝片抗肝纤维化机制的临床病理研究[J]. 解放军医学杂志, 2004,29(7):563-564
[23] 胡义扬, 刘平, 刘成 , 等. 大黄虫丸抗慢性肝损伤及肝纤维化作用的实验研究[J]. 中西医结合肝病杂志, 1995,5(3):28-30
[24] 孙克伟, 陈翔, 刘伟士 , 等. 大黄虫丸抗大鼠免疫性肝纤维化研究[J]. 中国中药杂志, 1998,23(8):497-499
[25] 刘平, 刘成, 陈高潮 , 等. 扶正化瘀319方治疗慢性乙型肝炎及其对纤维化血清学指标的影响[J]. 中国中西医结合杂志, 1996,16(10):588-592
doi: 10.7661/CJIM.1996.10.588
[26] 邝卫红, 李建华 . 鳖甲煎汤抗大鼠肝纤维化作用[J]. 中药新药与临床药理, 2004,15(5):314-317
doi: 10.3321/j.issn:1003-9783.2004.05.005
[27] 赵治友, 钟庆平, 朱飞燕 , 等. 古方鳖甲煎丸抗肝纤维化40例疗效观察[J]. 肝脏, 2001,6(2):105-106
[28] Shimizu I . Sho-saiko-to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma[J]. J Gastroenterol Hepatol, 2000,15(Suppl):D84-D90
doi: 10.1046/j.1440-1746.2000.02138.x pmid: 10759225
[29] 杨柳明, 徐克成, 赵延龙 , 等. 强肝胶囊治疗慢性乙型肝炎肝纤维化的临床病理研究[J]. 胃肠病学和肝病学杂志, 2001,10(3):247-249
[30] 尹珊珊, 王宝恩, 王泰龄 , 等. 复方861治疗慢性乙型肝炎肝纤维化与早期肝硬化的临床研究[J]. 中华肝脏病杂志, 2004,12(8):467-470
doi: 10.3760/j.issn:1007-3418.2004.08.007
[31] 程明亮, 丁一生, 罗永芳 , 等. 汉丹必妥治疗慢性活动性肝炎肝纤维化的临床研究[J]. 中国中西医结合杂志, 1996,16(7):431-432
doi: 10.7661/CJIM.1996.7.431
[32] 翁红雷, 蔡卫民, 王宝恩 , 等. 重组干扰素γ治疗慢性乙型肝炎肝纤维化临床研究[J]. 中华医学杂志, 2003,83(11):943-947
[33] 杜心芳, 翁红雷, 蔡卫民 . IFN-γ治疗20例慢性乙型肝炎肝纤维化患者肝组织学变化[J]. 中华肝脏病杂志, 2001,9(5):273-275
doi: 10.3760/j.issn:1007-3418.2001.05.007
[34] 茅益民, 曾民德, 陆伦根 , 等. 氧化苦参碱胶囊治疗慢性病毒性肝炎肝纤维化的随机、双盲、安慰剂对照多中心临床研究(II)[J]. 肝脏, 2002,7(4):222-225
doi: 10.3969/j.issn.1008-1704.2002.04.003
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