Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (7): 726-737.doi: 10.3736/jcim20120702

Special Issue: Traditional Chinese Medicine

• Literature Research • Previous Articles     Next Articles

A review of research on the development of instruments for therapeutic efficacy evaluation of traditional Chinese medicine

Wei-hua Xu1(), Ze-huai Wen1,2, Wei-xiong Liang1, Qi Wang1   

  1. 1. DME Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
    2. Key Unit of Methodology in Clinical Research of Traditional Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong Province, China
  • Received:2012-01-19 Accepted:2012-03-08 Online:2012-07-20 Published:2018-07-15
  • Contact: Wei-hua Xu

Objective: Due to the differences between Chinese and Western cultures, Chinese version of foreign research instruments may not be totally applicable for use in evaluating the therapeutic effect of traditional Chinese medicine (TCM). Great efforts have been made by Chinese researchers to develop scales for evaluation of the therapeutic effects of TCM. This study aims to understand the current situation of research in the development of evaluation instrument in TCM.
Methods: Database searches of Chinese Biomedical Literature Database, China Academic Journal Network Publishing Database and Chinese Scientific Journals Database were undertaken to identify published studies with the purpose of developing instruments in assessing the effectiveness of TCM, including papers regarding the construction of conceptual framework of instrument, item generation and selection and the evaluation of measurement properties.
Results: A total of 60 pieces of literature involving 36 instruments were included. The first article on the development of each of the instruments was published between 2005 and 2011 and the instruments were used in many kinds of medical conditions, including cardiocerebrovascular, respiratory, digestive and infectious diseases. The number of items ranged from 10 to 52. Of the 36 instruments, 13 (36.1%) defined the hypothesized concepts measured by the instrument, 30 (83.3%) reported the domains of the questionnaires before measurement property testing and all of them were multidomain. Of 32 studies regarding item selection and the instrument’s property evaluation, 14 (43.8%) articles reported the administration mode, 24 (75%) reported response option types, and 10 (31.5%) provided scoring algorithm for the scale, but none of these 32 studies specified the recall period. In 29 studies aiming at testing instrument’s measurement property, 28 articles tested the Cronbach’s α coefficient of the full scale and/or subscales, and retest reliability was also detected in 15 studies. Twenty-seven studies evaluated the construct validity by exploratory factor analysis and among them there were two studies applying confirmatory factor analysis. Content validity, responsiveness and feasibility of instruments were assessed in 11, 16 and 16 studies, respectively.
Conclusion: This study shows that in recent years many instruments have been developed in an attempt to evaluate the therapeutic effects of TCM, but some problems still exist in their practical implementation, including negligence in outlining the hypothesized concepts of the TCM instruments and in the reporting of instrument’s content validity such as administration mode, scoring and recall period. Some instrument attributes and testing methods were misunderstood and/or misused. Revision of instruments is rarely carried out, though the development of an instrument is an iterative process. Researchers should have a thorough understanding of the general procedure and steps before starting to develop an instrument.

Key words: traditional Chinese medicine, drugs, Chinese herbal, treatment outcome, questionnaires, review


编号 量表名称 相关文献
文献研究内容 构建
条目筛选 考评
1 原发性高血压肝阳上亢证评定量表 1[4] 2006 2 14
2 基于心血管疾病病人报告的临床疗效评价量表 1[5] 2008 3 28
3 中医特色冠心病生存质量量表 2[6,7] 2008 7 29
4 基于冠心病心绞痛患者报告临床结局评价量表 3[8,9,10] 2010 5 36
5 慢性心力衰竭中西医结合生存质量量表 2[11,12] 2008 6 36
6 基于中风痉挛性瘫痪患者报告的临床结局评价量表 4[13,14,15,16] 2008 3 19
7 中风病患者生存质量量表 2[17,18] 2006 4 36
8 中医中风生存质量量表 2[19,20] 2008 4 15
9 基于偏头痛患者报告的结局评价量表 1[21] 2011 未说明 23
10 颈椎病(神经根型)中医证候测评量表 2[22,23] 2006 6 21
11 神经根型颈椎病“病证结合”评价量表 2[24,25] 2011 3 47
12 慢性阻塞性肺疾病稳定期患者报告结局量表 3[26,27,28] 2011 3 23
13 慢性阻塞性肺疾病稳定期患者报告结局量表 1[29] 2011 3 17
14 中医慢性阻塞性肺疾病患者自报告量表 2[30,31] 2010 5 27
15 强直性脊柱炎患者生存质量测定量表 1[32] 2005 4 37
16 基于类风湿关节炎患者报告的临床结局测量量表 1[33] 2009 3 16
17 中医脾胃系疾病PRO量表 2[34,35] 2008 4 44
18 肝硬化中医生存质量量表 1[36] 2009 未说明 不详
19 慢性萎缩性胃炎癌前病变患者报告临床结局评价量表 1[37] 2011 3 30
20 中医肝病临床疗效评价量表 1[38] 2010 2
21 慢性乙型肝炎肝胆湿热证评定量表 1[39] 2007 未说明 13
22 慢性乙型肝炎脾虚证候量表 1[40] 2008 6 10
23 慢性乙型肝炎患者中医生存质量量表 1[41] 2010 4
24 慢性湿疹中医生存质量量表 1[42] 2008 未说明 26
25 银屑病患者生存质量量表 1[43] 2008 3 25
26 白癜风患者生存质量量表 1[44] 2010 3 25
27 斑秃中医生活质量量表 1[45] 2010 3 29
28 艾滋病生存质量量表 2[46,47] 2009 4 46
29 重症肌无力患者PRO量表 3[48,49,50] 2009 5 52
30 乳腺癌术后抑郁障碍中医量表 1[51] 2010 3 36
31 乳腺癌中医PRO调查问卷的研究** 1[52] 2011 5
32 绝经综合征疗效评定量表 7[53,54,55,56,57,58,59] 2007 3 40
33 外科术后康复量表 1[60] 2007 未说明 10
34 中西医结合围手术期康复量表 1[61] 2011 6
35 小儿脑性瘫痪中医证候量表 1[62] 2010 4 64
36 中草药牙膏清热祛火功效评价量表 1[63] 2010 未说明 15
[1] Liu FB . Application and prospect of scale measurement and appraisal in the assessment in TCM therapeutic efficacy evaluation[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2007,27(12):1129-1132
刘凤斌 . 量表测评方法在中医临床疗效评价中的应用与展望[J]. 中国中西医结合杂志, 2007,27(12):1129-1132
[2] Scientific Advisory Committee of the Medical Outcomes Trust. Assessing health status and quality-of-life instruments: attributes and review criteria[J]. Qual Life Res, 2002,11(3):193-205
doi: 10.1023/A:1015291021312
[3] U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER), Center for Devices and Radiological Health (CDRH). Guidance for industry. Patient-reported outcome measures: use in medical product development to support labeling claims. (2009-12)[2011-05-09]. .
[4] Guo Q, Chen ZQ, Liu XZ, Shen DZ . Preliminary development and evaluation of the scale for primary hypertension with excessive rise of liver-yang[J]. Zhongguo Lin Chuang Kang Fu, 2006,10(43):20-23
郭全, 陈泽奇, 刘小珍, 申定珠 . 原发性高血压肝阳上亢证评定量表的初步编制及考评[J]. 中国临床康复, 2006,10(43):20-23
[5] Li LZ, Dong GJ, Wang CL, Shi DZ, Zi MJ, He FY, Liu BY . Statistical analysis of efficacy evaluation based on questionnaire of cardiovascular diseases[J]. Zhong Xi Yi Jie He Xin Nao Xue Guan Bing Za Zhi, 2008,6(7):757-759
doi: 10.3969/j.issn.1672-1349.2008.07.001
李立志, 董国菊, 王承龙, 史大卓, 訾明杰, 何翻云, 刘保延 . “基于心血管疾病病人报告的临床疗效评价量表”的研制及统计学分析[J]. 中西医结合心脑血管病杂志, 2008,6(7):757-759
doi: 10.3969/j.issn.1672-1349.2008.07.001
[6] Zhu T, Mao JY . Design idea of item of QOL scale with TCM characteristics to patients with CAD[J]. Liaoning Zhong Yi Yao Da Xue Xue Bao, 2008,10(7):11-13
doi: 10.3969/j.issn.1673-842X.2008.07.006
朱婷, 毛静远 . 中医特色冠心病生存质量量表条目的设计思路[J]. 辽宁中医药大学学报, 2008,10(7):11-13
doi: 10.3969/j.issn.1673-842X.2008.07.006
[7] Zhu T, Mao JY . Formulation and evaluation of QOL scale with TCM characteristics for patients with CAD[J]. Liaoning Zhong Yi Za Zhi, 2008,35(6):854-855
doi: 10.3969/j.issn.1000-1719.2008.06.027
朱婷, 毛静远 . 中医特色冠心病生存质量量表的制定及考评[J]. 辽宁中医杂志, 2008,35(6):854-855
doi: 10.3969/j.issn.1000-1719.2008.06.027
[8] He QY, Wang J, Shi Z, Xiong XJ . The conception of theoretical structure of PRO efficacy scale of traditional Chinese medicine in coronary heart disease[J]. Zhonghua Zhong Yi Yao Za Zhi, 2010,25(1):42-45
何庆勇, 王阶, 施展, 熊兴江 . 冠心病心绞痛中医PRO疗效评价量表理论结构模型构想[J]. 中华中医药杂志, 2010,25(1):42-45
[9] He QY, Wang J, Zhu MJ, Ma CS, Ye Y, Lin Q, Zhong JB, Tang YL, Xiong XJ, Wang YX, Jing L, Nong YB . Item selection analysis on rating scale based on angina pectoris patients-reported outcomes[J]. Zhonghua Zhong Yi Yao Za Zhi, 2010,25(12):2216-2221
何庆勇, 王阶, 朱明军, 马长生, 叶勇, 林谦, 衷敬柏, 汤艳莉, 熊兴江, 王永霞, 荆鲁, 农一兵 . 基于冠心病心绞痛患者报告临床结局评价量表的条目筛选分析[J]. 中华中医药杂志, 2010,25(12):2216-2221
[10] He QY, Wang J, Yao KW, Ma CS . Establishment and primary screening of primitive entry pool of rating scale for patient-reported outcomes of coronary heart disease angina[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2011,31(1):15-18
何庆勇, 王阶, 姚魁武, 马长生 . 冠心病心绞痛患者报告临床结局评价量表条目池的建立和初步筛选[J]. 中国中西医结合杂志, 2011,31(1):15-18
[11] Lin Q, Nong YB, Wan J, Lu JJ, Wen ZH, An C . A clinical study of scale for evaluating the quality of life in patients with chronic heart failure treated with traditional Chinese and Western medicine[J]. Zhongguo Zhong Xi Yi Jie He Ji Jiu Za Zhi, 2008,15(3):131-134
林谦, 农一兵, 万洁, 逯金金, 温志浩, 安超 . 慢性心力衰竭中西医结合生存质量量表的临床研究[J]. 中国中西医结合急救杂志, 2008,15(3):131-134
[12] Lu JJ, Lin Q, Nong YB, Wan J . Study on the reliability and responsibility of chronic heart failure quality of life scale of integrated Chinese and Western medicine with the 36-item short-form health status survey[J]. Zhong Yi Za Zhi, 2011,52(10):837-840
逯金金, 林谦, 农一兵, 万洁 . 慢性心力衰竭中西医结合生存质量量表与SF-36简明健康状况量表信度、反应度对比研究[J]. 中医杂志, 2011,52(10):837-840
[13] Zi MJ, Liu BY, Liu ZS, Hu JQ . Symptom evaluation based on apoplexy spastic-paralysis patients’ reported outcomes[J]. Zhong Yi Za Zhi, 2008,49(10):890-893
訾明杰, 刘保延, 刘志顺, 胡镜清 . 基于中风痉挛性偏瘫患者报告的自觉症状评价[J]. 中医杂志, 2008,49(10):890-893
[14] Wang Y, Zhao H, Liu ZS, Liu BY . Reliability, validity and response of patient-reported-outcome scale in stroke patients with spastic paralysis[J]. Zhongguo Quan Ke Yi Xue, 2009,12(7A):1168-1170
王扬, 赵宏, 刘志顺, 刘保延 . 基于中风痉挛性瘫痪患者报告的临床结局评价量表的信度、效度及反应度[J]. 中国全科医学, 2009,12(7A):1168-1170
[15] Zhang YH, Liu BY, He LY, Zi MJ, Liu ZS, Zhao H . Preliminary study on performance evaluation of “self-evaluating instrument based on patient reported outcome for apoplexy spastic-paralysis patients”[J]. Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2011,18(2):18-21
doi: 10.3969/j.issn.1005-5304.2011.02.009
张艳宏, 刘保延, 何丽云, 訾明杰, 刘志顺, 赵宏 . “基于中风痉挛性瘫痪患者报告的临床结局评价量表”性能评价的初步研究[J]. 中国中医药信息杂志, 2011,18(2):18-21
doi: 10.3969/j.issn.1005-5304.2011.02.009
[16] Zhang YH, Liu BY, He LY, Zi MJ, Liu ZS, Wang Y, Zhao H . Analyses on reliability and validity of the evaluation scale of patient-reported-outcome based on the windstroke patients with spastic paralysis[J]. Zhong Yi Za Zhi, 2008,49(8):698-700
张艳宏, 刘保延, 何丽云, 訾明杰, 刘志顺, 王寅, 赵宏 . 基于中风痉挛性瘫痪患者报告的临床结局评价量表的信度、效度分析[J]. 中医杂志, 2008,49(8):698-700
[17] Hu XJ, Zhang BL, Cai GX . Developing and evaluating a quality of life instrument for stroke patients[J]. Zhong Yi Yao Xue Kan, 2006,24(9):1638-1640
doi: 10.3969/j.issn.1673-7717.2006.09.025
胡学军, 张伯礼, 蔡光先 . 中风病患者生存质量量表的研制与考评[J]. 中医药学刊, 2006,24(9):1638-1640
doi: 10.3969/j.issn.1673-7717.2006.09.025
[18] Hu XJ, Zhang BL, Cai GX . Constituting and valuating a quality of life instruments for stroke patients(2) — with quality of life instruments for stroke patients attached[J]. Zhonghua Zhong Yi Yao Xue Kan, 2007,25(2):270-272
doi: 10.3969/j.issn.1673-7717.2007.02.035
胡学军, 张伯礼, 蔡光先 . 中风病患者生存质量量表的研制与考评(续)——附中风病患者生存质量量表[J]. 中华中医药学刊, 2007,25(2):270-272
doi: 10.3969/j.issn.1673-7717.2007.02.035
[19] Li H, Liang WX . Study and development of TCM stroke scale for quality of life measurement(1) — establishment of the scale[J]. Liaoning Zhong Yi Za Zhi, 2008,35(3):376-378
doi: 10.3969/j.issn.1000-1719.2008.03.028
李慧, 梁伟雄 . 中医中风生存质量量表的研究编制(1)——量表的建立[J]. 辽宁中医杂志, 2008,35(3):376-378
doi: 10.3969/j.issn.1000-1719.2008.03.028
[20] Li H, Liang WX . Study and development of TCM stroke scale for quality of life measurement(2) — verification of the scale[J]. Liaoning Zhong Yi Za Zhi, 2008,35(4):529-531
李慧, 梁伟雄 . 中医中风生存质量量表的研究编制(2)——量表的考核. 2008; 35(4):529-531.
[21] Yu LH, Zou YH, Cao KG . Symptom items selection for patient-reported outcome of migraine disorders[J]. Zhongguo Quan Ke Yi Xue, 2011,14(5B):1535-1536
doi: 10.3969/j.issn.1007-9572.2011.14.008
俞丽华, 邹忆怀, 曹克刚 . 基于偏头痛患者报告的结局评价量表症状条目初步筛选[J]. 中国全科医学, 2011,14(5B):1535-1536
doi: 10.3969/j.issn.1007-9572.2011.14.008
[22] Zhou JW, Zhang F, Li CY, Wang M . Preliminary research on the formation and validity of the TCM syndrome scale for patients with nerve-root cervical spondylosis[J]. Sichuan Yi Xue, 2006,27(8):777-779
周建伟, 张凡, 李春雨, 王敏 .颈椎病( 神经根型 ) 证候测评量表编制及效度初步考察[J]. 四川医学, 2006,27(8):777-779
[23] Zhou JW, Zhang F, Li CY, Wang M . Formation and reliability test of the TCM syndrome scale for patients with nerve-root cervical spondylosis[J]. Sichuan Zhong Yi, 2006,24(8):31-33
周建伟, 张凡, 李春雨, 王敏 .颈椎病( 神经根型 ) 中医证候测评量表编制及信度测试[J]. 四川中医, 2006,24(8):31-33
[24] Yan P, Zhou JW, Yu YM, Li J, Pi Y, Xie HJ, Han JT . Preliminary research on the reliability of the disease and syndrome combined scale on nerve-root cervical spondylosis[J]. Zhong Yi Zheng Gu, 2011,23(5):10-12, 18
严攀, 周建伟, 虞亚明, 李静, 皮燕, 谢慧君, 韩进涛 . 神经根型颈椎病“病证结合”评价量表信度的初步研究[J]. 中医正骨, 2011,23(5):10-12, 18
[25] Pi Y, Zhou JW, Yan P, Han JT . Preliminary research on the formulation of the evaluation scale for combining syndrome with nerve-root cervical spondylosis[J]. Jiangxi Zhong Yi Yao, 2011,42(8):6-9
doi: 10.3969/j.issn.0411-9584.2011.08.003
皮燕, 周建伟, 严攀, 韩进涛 . 神经根型颈椎病“病证结合”评价量表的初步编制[J]. 江西中医药, 2011,42(8):6-9
doi: 10.3969/j.issn.0411-9584.2011.08.003
[26] Jiang FC, Li YL . Hypothesizing the conceptual framework of a PRO scale with TCM characteristics for patients with stable chronic obstructive pulmonary disease[J]. Zhong Yi Za Zhi, 2011,52(12):1008-1010
江芳超, 李友林 . 反映中医内容特征的慢性阻塞性肺疾病稳定期PRO量表理论结构模型的构建思路[J]. 中医杂志, 2011,52(12):1008-1010
[27] Li YL, Zhu YB, Wang W . Constructing the structure of the patient-reported outcome scale for patients with stable chronic obstructive pulmonary disease based on the theory of “unity of body and spirit”[J]. Shandong Zhong Yi Yao Da Xue Xue Bao, 2011,35(3):220-221
李友林, 朱燕波, 王伟 . 基于“形神一体观”建立COPD稳定期疗效量表的思路[J]. 山东中医药大学学报, 2011,35(3):220-221
[28] Zhu YB, Li YL, Wang W, Jiang FC . Development of a patient-reported outcome scale for stable chronic obstructive pulmonary disease and its clinical applicability[J]. J Chin Integr Med, 2011,9(8):857-865
朱燕波, 李友林, 王伟, 江芳超 . 慢性阻塞性肺疾病稳定期患者报告结局量表的研制与临床适用性[J]. 中西医结合学报, 2011,9(8):857-865
[29] Li JS, Wang MH, Yu XQ, Li SY, Wang HF, Li Y . Study and preliminary assessment of chronic obstructive pulmonary disease patients report circulating ending scale[J]. Zhong Yi Xue Bao, 2011,26(3):270-274
李建生, 王明航, 余学庆, 李素云, 王海峰, 李亚 . 慢性阻塞性肺疾病稳定期患者报告结局量表的研制及初步考核[J]. 中医学报, 2011,26(3):270-274
[30] Ren M, Sun ZT, Feng JH, Shang HC, Zhang BL . Establishment of the conceptual framework of self-reported scale for patients with chronic obstruction pulmonary disease in TCM[J]. Zhongguo Zhong Yi Yao Xian Dai Yuan Cheng Jiao Yu, 2010,8(17):151-153
doi: 10.3969/j.issn.1672-2779.2010.18.120
任明, 孙增涛, 封继宏, 商洪才, 张伯礼 . 中医慢性阻塞性肺疾病病人自报告量表(TCMPRO-COPD)理论模型的建立[J]. 中国中医药现代远程教育, 2010,8(17):151-153
doi: 10.3969/j.issn.1672-2779.2010.18.120
[31] Ren M, Sun ZT, Feng JH, Liu WW, Li J, Liu D, Shang HC . Evaluating of self-reported scale for patients with chronic obstruction pulmonary disease in TCM[J]. Tianjin Zhong Yi Yao, 2011,28(2):101-103
doi: 10.3736/jcim20110602
任明, 孙增涛, 封继宏, 刘薇薇, 李晶, 刘丹, 商洪才 . 中医慢性阻塞性肺疾病患者自报告量表的考核[J]. 天津中医药, 2011,28(2):101-103
doi: 10.3736/jcim20110602
[32] Liu XL, Deng J, Liu FB, Chen XG, Chen JF . Establishment of the scale of the quality of life for ankylosing spondylists[J]. Guangzhou Zhong Yi Yao Da Xue Xue Bao, 2005,22(4):315-319
刘晓玲, 邓健, 刘凤斌, 陈光星, 陈纪藩 . 强直性脊柱炎患者生存质量测定量表的制定[J]. 广州中医药大学学报, 2005,22(4):315-319
[33] Liu HX, Jiang Q, Liu BY, Zi MJ, Mu XZ, Wang HL . Preliminary construction of questionnaire based on rheumatoid arthritis patients-reported outcomes[J]. Zhong Yi Za Zhi, 2009,50(6):503-506
刘宏潇, 姜泉, 刘保延, 訾明杰, 母小真, 王海隆 . 基于类风湿关节炎患者报告的临床结局测量量表的初步构建[J]. 中医杂志, 2009,50(6):503-506
[34] Liu FB, Wang WQ . Consideration of constructing the conceptual framework of a PRO scale for spleen-stomach diseases in TCM[J]. Guangzhou Zhong Yi Yao Da Xue Xue Bao, 2008,25(1):12-14
刘凤斌, 王维琼 . 中医脾胃系疾病PRO量表理论结构模型的构建思路[J]. 广州中医药大学学报, 2008,25(1):12-14
[35] Liu FB, Wang WQ . Establishment of the spleen-stomach patients reported outcomes scale in Chinese medicine and the corresponding item selection[J]. Shi Jie Ke Xue Ji Shu Zhong Yi Yao Xian Dai Hua, 2009,11(4):527-531
刘凤斌, 王维琼 . 中医脾胃系疾病PRO量表的研制与条目筛选[J]. 世界科学技术——中医药现代化, 2009,11(4):527-531
[36] Wang TF, Shi PY . A study on quality of life scale in patients with liver cirrhosis[J]. Zhonghua Shi Yong Zhong Xi Yi Za Zhi, 2009,22(9):503-505
王同发, 石鹏岩 . 肝硬化中医生存质量量表的研制与验证[J]. 中华实用中西医杂志, 2009,22(9):503-505
[37] Liu L, Chang YS, Shen SW, Yuwen Y, Hui JP, Huang YJ . Development and reliability and validity analysis of patient-reported outcome scale for precancerous lesion of atrophic gastritis[J]. Zhong Yi Za Zhi, 2011,52(10):834-836
刘力, 常玉双, 沈舒文, 宇文亚, 惠建萍, 黄毓娟 . 慢性萎缩性胃炎癌前病变患者报告临床结局评价量表的编制及信度、效度分析[J]. 中医杂志, 2011,52(10):834-836
[38] She SF, Liu FB, Luo SJ . Discussion on constructing the conceptual framework of an assessing scale for the curative effect of patients with liver disease in TCM[J]. Zhong Yao Xin Yao Yu Lin Chuang Yao Li, 2010,21(4):449-450
佘世锋, 刘凤斌, 罗仕娟 . 中医肝病临床疗效评价量表理论结构模型构建的探讨[J]. 中药新药与临床药理, 2010,21(4):449-450
[39] Guo Q, Chen ZQ, Liu XZ, Shen DZ . Preliminary development and evaluation of scale for chronic hepatitis B with type of damp-heat in liver and gallbladder[J]. Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2007,14(7):9-12
郭全, 陈泽奇, 刘小珍, 申定珠 . 慢性乙型肝炎肝胆湿热证评定量表的初步编制及考评[J]. 中国中医药信息杂志, 2007,14(7):9-12
[40] Le M, Huang X, Gao YQ . Establishment of measurement scale for spleen deficiency syndrome in chronic hepatitis B[J]. Shanghai Zhong Yi Yao Za Zhi, 2008,42(3):6-9
乐敏, 黄杏, 高月求 . 慢性乙型肝炎脾虚证候量表研制初探[J]. 上海中医药杂志, 2008,42(3):6-9
[41] Zhang W . Consideration on establishing a traditional Chinese medicine quality of life scale for patients with chronic hepatitis B[J]. Zhong Xi Yi Jie He Gan Bing Za Zhi, 2010,20(1):53-55
张玮 . 建立慢性乙型肝炎患者中医生存质量量表的设想[J]. 中西医结合肝病杂志, 2010,20(1):53-55
[42] Yang ZB, Liu J, Liu X, Sun J, Zeng BJ . Development of quality of life scale for chronic eczema patients[J]. Zhong Yi Yao Dao Bao, 2008,14(8):1-5
杨志波, 刘娟, 刘翔, 孙洁, 曾碧君 . 建立慢性湿疹中医生存质量量表的初步研究[J]. 中医药导报, 2008,14(8):1-5
[43] Yang ZB, Wang C . Development strategy and item selection of quality of life scale for psoriasis patient[J]. Zhong Yi Yao Dao Bao, 2008,14(9):4-7
doi: 10.3969/j.issn.1672-951X.2008.09.002
杨志波, 王畅 . 银屑病患者生存质量量表的编制策略及条目筛选[J]. 中医药导报, 2008,14(9):4-7
doi: 10.3969/j.issn.1672-951X.2008.09.002
[44] Xiang YP, Chen LM, Yang ZB, Wang C . Study of quality of life(QOL) scale on patients with vitiligo in TCM[J]. Hunan Zhong Yi Yao Da Xue Xue Bao, 2010,30(1):56-59
向亚平, 陈立明, 杨志波, 王畅 . 白癜风患者中医生存质量量表的研究[J]. 湖南中医药大学学报, 2010,30(1):56-59
[45] Zhu MF, Ren Q, Tan QW, Liu X, Yang ZB, Wang JW, Zhang YM . Study on quality of life scale for patients with alopecia areata in TCM[J]. Hunan Zhong Yi Yao Da Xue Xue Bao, 2010,30(9):149-151
doi: 10.3969/j.issn.1674-070X.2010.
朱明芳, 任群, 谭清文, 刘翔, 杨志波, 王军文, 张依敏 . 建立斑秃中医生活质量量表的初步研究[J]. 湖南中医药大学学报, 2010,30(9):149-151
doi: 10.3969/j.issn.1674-070X.2010.
[46] Zhang ML, Wei JY, Wu YM, Guo XX, Su FJ . Preparing scale of living quality on HIV/AIDS(HIV/AIDSQOL-46)[J]. Zhong Yi Xue Bao, 2009,24(5):6-8
张明利, 魏俊英, 吴毓敏, 郭选贤, 苏方静 . 艾滋病生存质量量表(HIV/AIDSQOL-46)的研制[J]. 中医学报, 2009,24(5):6-8
[47] Zhang ML, Wei JY, Wu YM, Guo XX . Study on assessing the quality of life scale for HIV/AIDS(HIV/AIDSQOL-46)[J]. Zhong Yi Yan Jiu, 2009,22(11):10-13
doi: 10.3969/j.issn.1001-6910.2009.11.005
张明利, 魏俊英, 吴毓敏, 郭选贤 . 艾滋病生存质量量表(HIV/AIDSQOL-46)的测评研究[J]. 中医研究, 2009,22(11):10-13
doi: 10.3969/j.issn.1001-6910.2009.11.005
[48] Liu FB, Guo L, Liu XB . Discussion on establishing the conceptual framework of the patient-reported outcome scale for myasthenia gravis[J]. Xin Zhong Yi, 2009,41(9):27-29
刘凤斌, 郭丽, 刘小斌 . 建立中医重症肌无力PRO量表的理论结构模型构想的探讨[J]. 新中医, 2009,41(9):27-29
[49] Guo L, Liu FB, Chen XL . Establishment of the patient-reported outcome scale for myasthenia gravis and the corresponding item selection[J]. Guangzhou Zhong Yi Yao Da Xue Xue Bao, 2009,26(6):570-573
郭丽, 刘凤斌, 陈新林 . 重症肌无力患者PRO量表的研制和条目筛选[J]. 广州中医药大学学报, 2009,26(6):570-573
[50] Chen XL, Liu FB, Guo L, Liu XB . Development of patient-reported outcome scale for myasthenia gravis: a psychometric test[J]. J Chin Integr Med, 2010,8(2):121-125
陈新林, 刘凤斌, 郭丽, 刘小斌 . 重症肌无力患者报告结局指标量表的研制——计量心理学测评[J]. 中西医结合学报, 2010,8(2):121-125
[51] Gao XF, Liu S, Chen HF, Que HF, Lu JG, Cao YQ, Chen WJ, Qiu JY . Development and preliminary application of the TCM scale of depression after breast cancer[J]. Zhonghua Zhong Yi Yao Za Zhi, 2010,25(12):2264-2267
高秀飞, 刘胜, 陈红风, 阙华发, 陆金根, 曹永清, 陈维珺, 仇剑崟 . 乳腺癌术后抑郁障碍中医量表的研制[J]. 中华中医药杂志, 2010,25(12):2264-2267
[52] Zhang J, Shen Y, Bian WH, Pan LQ . Research on the design of primary TCM PRO questionnaire for breast cancer[J]. Nanjing Zhong Yi Yao Da Xue Xue Bao, 2011,27(3):295-297
张珺, 沈毅, 卞卫和, 潘立群 . 乳腺癌中医PRO调查问卷的研究[J]. 南京中医药大学学报, 2011,27(3):295-297
[53] Yang HY, Wang XY, Nie GN, Xie YN, Wen ZH, Zhang CL, Cheng FP, Zhao CM . Construction of outcome assessment scale in menopause syndrome[J]. Xun Zheng Yi Xue, 2007,7(3):172-174, 192
doi: 10.3969/j.issn.1671-5144.2007.03.018
杨洪艳, 王小云, 聂广宁, 解亚宁, 温泽淮, 张春玲, 成方平, 赵春梅 . 绝经综合征疗效评定量表构建思路和循证研究探讨[J]. 循证医学, 2007,7(3):172-174, 192
doi: 10.3969/j.issn.1671-5144.2007.03.018
[54] Wang XY, Yang HY, Nie GN, Wen ZH, Sun YM, Cheng FP, Wu DR, Lai SL . Constructing thinking of the Chinese menopause rating scale[J]. Xing Zhong Yi, 2007,39(3):4-6
王小云, 杨洪艳, 聂广宁, 温泽淮, 孙艳梅, 成方平, 吴大嵘, 赖世隆 . 绝经综合征疗效评定量表设计思路[J]. 新中医, 2007,39(3):4-6
[55] Nie GN, Yang HY, Wang XY, Wen ZH, Wang L, Xie YN, Wu DR, Zhao CM . The construction and preliminary screening of item pool on Chinese menopause rating scale[J]. Xun Zheng Yi Xue, 2008,8(3):177-180
doi: 10.3969/j.issn.1671-5144.2008.03.013
聂广宁, 杨洪艳, 王小云, 温泽淮, 王玲, 解亚宁, 吴大嵘, 赵春梅 . 绝经综合征评定量表条目池的建立和初步筛选研究[J]. 循证医学, 2008,8(3):177-180
doi: 10.3969/j.issn.1671-5144.2008.03.013
[56] Wen ZH, Nie GN, Wang XY, Yang HY, Zhang CL, Wu DR, Wei SB, He JC, Lu S . Pretest survey on the Chinese menopause rating scale[J]. Zhonghua Liu Xing Bing Xue Za Zhi, 2008,29(10):985-988
温泽淮, 聂广宁, 王小云, 杨洪艳, 张春玲, 吴大嵘, 魏绍斌, 何金彩, 卢苏 . 绝经综合征评定量表的预调查研究[J]. 中华流行病学杂志, 2008,29(10):985-988
[57] Wang XY, Yang HY, Nie GN, Wen ZH, Wu DR, Zhang CL, Wang L, Jiang HZ, Han LL . Study on reliability and validity of the Chinese menopause rating scale(CMRS)[J]. Zhonghua Liu Xing Bing Xue Za Zhi, 2008,29(9):882-886
doi: 10.3321/j.issn:0254-6450.2008.09.008
王小云, 杨洪艳, 聂广宁, 温泽淮, 吴大嵘, 张春玲, 王玲, 姜惠中, 韩丽琳 . 绝经综合征评定量表的信度、效度、反应度研究[J]. 中华流行病学杂志, 2008,29(9):882-886
doi: 10.3321/j.issn:0254-6450.2008.09.008
[58] Wang XY, Nie GN, Yang HY, Wen ZH, Zhang CL, Qing LH, Zhao CM . A confirmatory analysis of the structure of the Chinese menopause rating scale[J]. Jun Yi Jin Xiu Xue Yuan Xue Bao, 2010,31(5):440-441
王小云, 聂广宁, 杨洪艳, 温泽淮, 张春玲, 秦莉花, 赵春梅 . 绝经综合征评定量表的验证性因素分析[J]. 军医进修学院学报, 2010,31(5):440-441
[59] Nie GN, Wang XY, Yang HY . Research on the test and adjustment of rating scale of menopausal syndrome[J]. Zhong Yi Xue Bao, 2011,26(4):461-462
聂广宁, 王小云, 杨洪艳 . 绝经综合征评定量表的试测与调适研究[J]. 中医学报, 2011,26(4):461-462
[60] Wang ZH, Chen ZQ, Wang SS, Ou AH, Mao W . Preliminary establishment and assessment of postoperative recovery scale[J]. Guangzhou Zhong Yi Yao Da Xue Xue Bao, 2007,24(3):195-197
王昭辉, 陈志强, 王树声, 欧爱华, 毛炜 . 外科术后康复量表的制订与初步评价[J]. 广州中医药大学学报, 2007,24(3):195-197
[61] Su BY, Liu SN, Li XY, Wen ZH, Cao LX, Wu DR, Chen ZQ . Development of the theoretical framework and the item pool of the peri-operative recovery scale for integrative medicine[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2011,31(11):1554-1560
苏碧莹, 刘少南, 李晓彦, 温泽淮, 曹立幸, 吴大嵘, 陈志强 . 中西医结合围手术期康复量表理论框架及条目池构建[J]. 中国中西医结合杂志, 2011,31(11):1554-1560
[62] Huang W, Wang XF . Preliminary evaluation of traditional Chinese medicine syndrome scale for children with cerebral palsy[J]. Zhong Yi Kang Fu Li Lun Yu Shi Jian, 2010,16(7):608-609
黄伟, 王雪峰 . 小儿脑性瘫痪中医证候量表的初步考核[J]. 中医康复理论与实践, 2010,16(7):608-609
[63] Peng JQ, Zhao H, Chen JX, Wang SX, Li XH, Cui HZ, Ji N, Li C, Sun LL, Wang N . Validity and response of clearing heat to eliminate fire efficacy scale of Chinese herbal toothpastes[J]. Zhonghua Zhong Yi Yao Za Zhi, 2010,25(8):1324-1326
彭建琼, 赵晖, 陈家旭, 王少贤, 李晓红, 崔海珍, 吉宁, 李春, 孙丽丽, 王楠 . 中草药牙膏清热祛火功效评价量表的信度与效度分析[J]. 中华中医药杂志, 2010,25(8):1324-1326
[64] Fowler FJ . Patient reports of symptoms and quality of life following prostate surgery[J]. Eur Urol, 1991,20(Suppl 1):44-49
doi: 10.1159/000471746
[65] U. S Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER). Guidance for industry: clinical trial endpoints for the approval of cancer drugs and biologics. (2007-05)[2011-05-09] .S Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER). Guidance for industry: clinical trial endpoints for the approval of cancer drugs and biologics. (2007-05)[2011-05-09] .
[66] Guo QK. Principle and application of psychological testing[M]. Beijing: People’s Military Medical Press, 2002: 82
郭庆科 . 心理测验的原理与应用[M]. 北京: 人民军医出版社, 2002: 82
[67] Wu ML. Application of statistical package for the social science: analysis and statistics of questionnaire[M]. Beijing: Science Press, 2003: 108-109
吴明隆 . SPSS统计应用务实——问卷分析与应用统计[M]. 北京: 科学出版社, 2003: 108-109
[68] Xu WH, Liang WX, Wang Q, Wen ZH . Problems to pay attention to in taking patient-reported outcomes as clinical outcomes assessment[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2011,31(8):1135-1137, 1145
许卫华, 梁伟雄, 王奇, 温泽淮 . 以患者报告结局为疗效评价指标时需注意的问题[J]. 中国中西医结合杂志, 2011,31(8):1135-1137, 1145
[1] Sherman Gu, Arthur Yin Fan. Controversial conclusions from two randomized controlled trials for acupuncture's effects on polycystic ovary syndrome or in vitro fertilization support. Journal of Integrative Medicine, 2020, 18(2): 89-91.
[2] Xue-qing Yu, Shu-guang Yang, Yang Xie, Jian-sheng Li. Traditional Chinese medicine in the treatment of idiopathic pulmonary fibrosis based on syndrome differentiation: Study protocol of exploratory trial. Journal of Integrative Medicine, 2020, 18(2): 163-168.
[3] Deng-hai Zhang, Kun-lun Wu, Xue Zhang, Sheng-qiong Deng, Bin Peng. In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus. Journal of Integrative Medicine, 2020, 18(2): 152-158.
[4] Chang-quan Ling. Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2). Journal of Integrative Medicine, 2020, 18(2): 87-88.
[5] Dona Nirmani Ann Wijewickrama Samarakoon, Deepthi Inoka Uluwaduge, Malith Aravinda Siriwardhene. Mechanisms of action of Sri Lankan herbal medicines used in the treatment of diabetes: A review. Journal of Integrative Medicine, 2020, 18(1): 13-20.
[6] Wen Qiang Lee, Jeremy Teoh, Pei Zheng Kenneth Lee, Zhi Xiong Gerard Low, Xueling Sim, Foong Fong Mary Chong, Norbert Ludwig Wagner. Factors influencing communication of traditional Chinese medicine use between patients and doctors: a multisite cross-sectional study. Journal of Integrative Medicine, 2019, 17(6): 396-403.
[7] Lena Grönblom Lundström, Ulrika Aasa, Yan Zhang, Tobias Sundberg. Health care in light of different theories of health—A proposed framework for integrating a social humanistic perspective into health care. Journal of Integrative Medicine, 2019, 17(5): 321-327.
[8] Mikhail Teppone. Medicine has always been “Modern” and “Scientific” from ancient times to the present day. Journal of Integrative Medicine, 2019, 17(4): 229-237.
[9] Charles Dalcanale Tesser, Ari Ojeda Ocampo Moré, Melissa Costa Santos, Emiliana Domingues Cunha da Silva, Fátima Terezinha Pelachini Farias, Lúcio José Botelho. Auriculotherapy in primary health care: A large-scale educational experience in Brazil. Journal of Integrative Medicine, 2019, 17(4): 302-309.
[10] Rachael Farrington, Ian F.Musgrave, Roger W.Byard. Evidence for the efficacy and safety of herbal weight loss preparations. Journal of Integrative Medicine, 2019, 17(2): 87-92.
[11] Fung-Kei Cheng. An overview of the contribution of acupuncture to thyroid disorders. Journal of Integrative Medicine, 2018, 16(6): 375-383.
[12] Jia Xu, Fu-qing Zhang, Jian Pei, Jun Ji . Acupuncture for migraine without aura: A systematic review and meta-analysis. Journal of Integrative Medicine, 2018, 16(5): 312-321.
[13] Chang-quan Ling, Jia Fan, Hong-sheng Lin, Feng Shen, Zhen-ye Xu, Li-zhu Lin, Shu-kui Qin, Wei-ping Zhou, Xiao-feng Zhai, Bai Li, Qing-hui Zhou, on behalf of the Chinese Integrative Therapy of Primary Liver Cancer Working Group. Clinical practice guidelines for the treatment of primary liver cancer with integrative traditional Chinese and Western medicine. Journal of Integrative Medicine, 2018, 16(4): 236-248.
[14] Carola Analía Torres, Cristina Marisel Pérez Zamora, María Beatriz Nuñez, Ana María Gonzalez. In vitro antioxidant, antilipoxygenase and antimicrobial activities of extracts from seven climbing plants belonging to the Bignoniaceae. Journal of Integrative Medicine, 2018, 16(4): 255-262.
[15] Hidetoshi Mori, Hiroshi Kuge, Shunji Sakaguchi, Tim Hideaki Tanaka, Junji Miyazaki. Determination of symptoms associated with hiesho among young females using hie rating surveys. Journal of Integrative Medicine, 2018, 16(1): 34-38.
Full text



[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[3] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[4] Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[5] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. Guiding principles of clinical research on mild cognitive impairment (protocol). Journal of Chinese Integrative Medicine, 2008, 6(1): 9-14
[6] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[8] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022
[9] Wei Xu, Meng Shi, Jian-gang Liu, Cheng-long Wang . Collagen protein expressions in ischemic myocardium of rats with acute myocardial infarction and effects of qi-tonifying, yin-tonifying and blood-activating herbs and detoxifying and blood-activating herbs. Journal of Chinese Integrative Medicine, 2010, 8(11): 1041-1047
[10] Ya-hui Liang , Ping Li, Jing-xia Zhao, Xin Liu, Qi-fu Huang. Acetyl-11-keto-beta-boswellic acid and arsenic trioxide regulate the productions and activities of matrix metalloproteinases in human skin fibroblasts and human leukemia cell line THP-1. Journal of Chinese Integrative Medicine, 2010, 8(11): 1060-1069