Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (6): 551-555.doi: 10.3736/jcim20060601

• Editorial •     Next Articles

Guideline for the diagnosis and treatment of liver fibrosis with integrative medicine

Chinese Association of Integrative Medicine, Liver Disease Committee   

  • Online:2006-11-30 Published:2006-11-15

Key words: Liver fibrosis, Integrative medicine, Diagnosis, treatment, Guideline

CLC Number: 

  • R2-031

"

证据等级 定义
随机对照临床试验
Ⅱ-1 有对照但非随机的临床试验
Ⅱ-2 队列研究或病例对照研究
Ⅱ-3 多时间点病例系列分析,结果明显的非对照试验
专家观点及描述性流行病学研究

"

炎症活动度 纤维化程度
级(G) 汇管区及周围 小叶内 期(S) 纤维化程度
0 无炎症 无炎症 0
1 汇管区炎症 变性及少数点状坏死 1 汇管区纤维化扩大,局限窦周及小叶内纤维化
2 轻度PN或嗜酸小体 变性,点、灶状坏死 2 汇管区周围纤维化,纤维间隔形成,小叶结构保留
3 中度PN 融合坏死或见BN 3 纤维间隔伴小叶结构紊乱,无肝硬化
4 重度PN BN广泛,累及多个小叶(多小叶坏死) 4 早期肝硬化
[1] Liaw YF, Tai DI, Chu CM , et al. The development of cirrhosis in patients with chronic type B hepatitis: a prospective study[J]. Hepatology, 1988,8(3):493-496
[2] Hsu YS, Chien RN, Yeh CT , et al. Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B[J]. Hepatology, 2002,35(6):1522-1527
doi: 10.1053/jhep.2002.33638 pmid: 12029639
[3] 巫贵成, 周卫平, 赵有蓉 , 等. 慢性乙型肝炎自然史的研究[J]. 中华肝脏病杂志, 2002,10(1):46-48
[4] 中华肝脏病学会肝纤维化学组. 肝纤维化诊断及疗效评估共识[J]. 中华肝脏病杂志, 2002,10(5):327-328
[5] Knodell RG, Ishak KG, Black WC , et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis[J]. Hepatology, 1981,1(5):431-435
[6] Ishak KG . Pathologic features of chronic hepatitis. A review and update[J]. Am J Clin Patho1, 2000,113(1):40-55
[7] Scheuer PJ, Standish RA , Dhillon AP.Scoring of chronic hepatitis[J].Clin Liver Dis, 2002, 6(2):335-347, ⅴ-ⅵ
[8] Chevallier M, Guerret S, Chossegros P , et al. A histological semiquantitative scoring system for evaluation of hepatic fibrosis in needle liver biopsy specimens: comparison with morphometric studies[J]. Hepatology, 1994,20(2):349-355
[9] 上海市肝纤维化课题协作组. 肝纤维化的CT、MR诊断初步探讨[J]. 上海医学, 2002,25(4):210-213
doi: 10.3969/j.issn.0253-9934.2002.04.005
[10] Bissell DM . Assessing fibrosis without a liver biopsy: are we there yet?[J]. Gastroenterology, 2004,127(6):1847-1849
doi: 10.1053/j.gastro.2004.10.012 pmid: 15578524
[11] Rosenberg WM, Voelker M, Thiel R , et al. Serum markers detect the presence of liver fibrosis: a cohort study[J]. Gastroenterology, 2004,127(6):1704-1713
[12] Kelleher TB, Mehta SH, Bhaskar R , et al. Prediction of hepatic fibrosis in HIV/HCV co-infected patients using serum fibrosis markers: The SHASTA index[J]. J Hepatol, 2005,43(1):78-84
[13] Zeng MD, Lu LG, Mao YM , et al. Prediction of significant fibrosis in HBeAg-positive patients with chronic hepatitis B by a noninvasive model[J]. Hepatology, 2005,42(6):1437-1445
[14] 曾民德, 陆伦根, 苏益民 . 肝纤维化的诊断方法及其评估(下)[J]. 肝脏, 2006,11(3):181-183
doi: 10.3969/j.issn.1008-1704.2006.02.011
[15] 张文胜, 王宝恩, 王泰龄 , 等. 慢性乙型肝炎肝纤维化无创性诊断模型的建立[J]. 中华肝脏病杂志, 2006,14(3):169-173
doi: 10.3760/j.issn:1007-3418.2006.03.004
[16] 中华医学会肝病学分会感染病学分会. 慢性乙型肝炎防治指南[J]. 中华肝脏病杂志, 2005,13(12):881-891
doi: 10.3969/j.issn.1008-7125.2006.10.010
[17] 中华医学会肝病学分会, 中华医学会传染病与寄生虫病学分会. 丙型肝炎防治指南[J]. 中华肝脏病杂志, 2004,12(4):194-198
[18] 中华医学会肝病学分会脂肪肝和酒精性肝病学组. 酒精性肝病诊疗指南[J]. 中华肝脏病杂志, 2006,14(3):164-166
doi: 10.3969/j.issn.1008-7125.2010.10.011
[19] 中华医学会肝病学分会脂肪肝和酒精性肝病学组. 非酒精性脂肪性肝病诊疗指南[J]. 中华肝脏病杂志, 2006,14(3):161-163
doi: 10.3969/j.issn.1008-1704.2006.01.032
[20] 中华人民共和国国家标准.UDC-GB15977. 日本血吸虫病诊断标准和处理标准. 1995.
[21] Liu P, Hu YY, Liu C , et al. Multicenter clinical study on Fuzhenghuayu capsule against liver fibrosis due to chronic hepatitis B[J]. World J Gastroenterol, 2005,11(19):2892-2899
[22] 周光德, 李文淑, 赵景民 , 等. 复方鳖甲软肝片抗肝纤维化机制的临床病理研究[J]. 解放军医学杂志, 2004,29(7):563-564
[23] 胡义扬, 刘平, 刘成 , 等. 大黄虫丸抗慢性肝损伤及肝纤维化作用的实验研究[J]. 中西医结合肝病杂志, 1995,5(3):28-30
[24] 孙克伟, 陈翔, 刘伟士 , 等. 大黄虫丸抗大鼠免疫性肝纤维化研究[J]. 中国中药杂志, 1998,23(8):497-499
[25] 刘平, 刘成, 陈高潮 , 等. 扶正化瘀319方治疗慢性乙型肝炎及其对纤维化血清学指标的影响[J]. 中国中西医结合杂志, 1996,16(10):588-592
doi: 10.7661/CJIM.1996.10.588
[26] 邝卫红, 李建华 . 鳖甲煎汤抗大鼠肝纤维化作用[J]. 中药新药与临床药理, 2004,15(5):314-317
doi: 10.3321/j.issn:1003-9783.2004.05.005
[27] 赵治友, 钟庆平, 朱飞燕 , 等. 古方鳖甲煎丸抗肝纤维化40例疗效观察[J]. 肝脏, 2001,6(2):105-106
[28] Shimizu I . Sho-saiko-to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma[J]. J Gastroenterol Hepatol, 2000,15(Suppl):D84-D90
doi: 10.1046/j.1440-1746.2000.02138.x pmid: 10759225
[29] 杨柳明, 徐克成, 赵延龙 , 等. 强肝胶囊治疗慢性乙型肝炎肝纤维化的临床病理研究[J]. 胃肠病学和肝病学杂志, 2001,10(3):247-249
[30] 尹珊珊, 王宝恩, 王泰龄 , 等. 复方861治疗慢性乙型肝炎肝纤维化与早期肝硬化的临床研究[J]. 中华肝脏病杂志, 2004,12(8):467-470
doi: 10.3760/j.issn:1007-3418.2004.08.007
[31] 程明亮, 丁一生, 罗永芳 , 等. 汉丹必妥治疗慢性活动性肝炎肝纤维化的临床研究[J]. 中国中西医结合杂志, 1996,16(7):431-432
doi: 10.7661/CJIM.1996.7.431
[32] 翁红雷, 蔡卫民, 王宝恩 , 等. 重组干扰素γ治疗慢性乙型肝炎肝纤维化临床研究[J]. 中华医学杂志, 2003,83(11):943-947
[33] 杜心芳, 翁红雷, 蔡卫民 . IFN-γ治疗20例慢性乙型肝炎肝纤维化患者肝组织学变化[J]. 中华肝脏病杂志, 2001,9(5):273-275
doi: 10.3760/j.issn:1007-3418.2001.05.007
[34] 茅益民, 曾民德, 陆伦根 , 等. 氧化苦参碱胶囊治疗慢性病毒性肝炎肝纤维化的随机、双盲、安慰剂对照多中心临床研究(II)[J]. 肝脏, 2002,7(4):222-225
doi: 10.3969/j.issn.1008-1704.2002.04.003
[1] Tara Rajendran. Addressing the need for personalizing music therapy in integrative oncology. Journal of Integrative Medicine, 2022, 20(4): 281-283.
[2] Ye-juan Jia, Tian-yu Li, Peng Han, Yu Chen, Li-jia Pan, Chun-sheng Jia. Effects of different courses of moxibustion treatment on intestinal flora and inflammation of a rat model of knee osteoarthritis. Journal of Integrative Medicine, 2022, 20(2): 173-181.
[3] Rui-jin Qiu, Min Li, Jia-yuan Hu, Jing Chen, Hong-cai Shang. Methods for development of a core outcome set for clinical trials integrating traditional Chinese medicine and Western medicine. Journal of Integrative Medicine, 2021, 19(5): 389-394.
[4] Sibel Şentürk, Dilek Efe Arslan, Adil Çetinkaya. Association of complementary and integrative therapy use and symptoms among Turkish patients with familial Mediterranean fever. Journal of Integrative Medicine, 2021, 19(4): 340-346.
[5] Ning Zhang, Xiao-he Xiao. Integrative medicine in the era of cancer immunotherapy: Challenges and opportunities. Journal of Integrative Medicine, 2021, 19(4): 291-294.
[6] Baoyi Shao, Saiying Hou, Yuenyan Chan, Changchun Shao, Lixing Lao. Remission of new-onset type 2 diabetes mellitus in an adolescent using an integrative medicine approach: A case report. Journal of Integrative Medicine, 2021, 19(1): 85-88.
[7] George Chengxi Bao. The idealist and pragmatist view of qi in tai chi and qigong: A narrative commentary and review. Journal of Integrative Medicine, 2020, 18(5): 363-368.
[8] Hepatology Committee of Chinese Association of Integrative Medicine, China. Guidelines for diagnosis and treatment of hepatic fibrosis with integrated traditional Chinese and Western medicine (2019 edition). Journal of Integrative Medicine, 2020, 18(3): 203-213.
[9] Brody Slostad, Tejinder Khalsa, Kathleen Young, Hildalicia Guerra, Anjali Bhagra. A case-based approach to integrative medicine for cardiovascular disease prevention. Journal of Integrative Medicine, 2020, 18(2): 159-162.
[10] Mikhail Teppone. Medicine has always been “Modern” and “Scientific” from ancient times to the present day. Journal of Integrative Medicine, 2019, 17(4): 229-237.
[11] Mohammad Hossein Ayati, Ata Pourabbasi, Nazli Namazi, Arman Zargaran, Zahra Kheiry, Amir Hooman Kazemi, Bagher Larijani. The necessity for integrating traditional, complementary, and alternative medicine into medical education curricula in Iran. Journal of Integrative Medicine, 2019, 17(4): 296-301.
[12] Tamer Aboushanab, Mohamed Khalil, YaserAl Ahmari. The present state of complementary medicine regulation in Saudi Arabia. Journal of Integrative Medicine, 2019, 17(3): 147-149.
[13] Arthur Yin Fan, Hui Ouyang, Xinru Qian, Hui Wei, David Dehui Wang, Deguang He, Haihe Tian, Changzhen Gong, Amy Matecki, Sarah Faggert Alemi. Discussions on real-world acupuncture treatments for chronic low-back pain in older adults. Journal of Integrative Medicine, 2019, 17(2): 71-76.
[14] Hanae Naceiri Mrabti, Nidal Jaradat, Mohamed Reda Kachmar, Abdelaziz Ed-Dra, Abdelilah Ouahbi, Yahia Cherrah, Moulay El Abbes Faouzi. Integrative herbal treatments of diabetes in Beni Mellal region of Morocco. Journal of Integrative Medicine, 2019, 17(2): 93-99.
[15] Fung-Kei Cheng. An overview of the contribution of acupuncture to thyroid disorders. Journal of Integrative Medicine, 2018, 16(6): 375-383.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228