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Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (7): 611-615.doi: 10.3736/jcim20090703

• Original Clinical Research • Previous Articles     Next Articles

Effects of Feitai Capsule on quality of life in patients with advanced non-small-cell lung cancer: A randomized controlled trial

Zhi-zhen Liu, Zong-yang Yu, Xue-nong Ouyang,Xi-hu Dai, Xi Chen, Zhong-quan Zhao, Wen-wu Wang, Jie Li, Hua Tu, Lei Ye, Yan Yan   

  1. Department of Oncology, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China
  • Received:2008-12-22 Accepted:2009-04-27 Online:2009-07-20 Published:2009-07-15
  • Contact: Xue-nong Ouyang E-mail:oyxn@pulic.fz.fj.cn

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Background

Recently the maintenance therapy of non-small-cell lung cancer (NSCLC) patients who completed required treatment cycles has caused widespread interests in the medical field. Traditional Chinese medicine may be a useful complement in maintenance treatment of mid-to-late stage NSCLC.
Objective

To observe the effects of Feitai Capsule, a compound traditional Chinese herbal medicine for expelling blood stasis and phlegm, on the quality of life of the NSCLC patients as a maintenance treatment.Design, setting, participants and interventions: A total of 62 mid-to-late stage NSCLC patients from Fuzhou General Hospital of Nanjing Military Region were included and randomly divided into treatment group (31 cases) and control group (31 cases). Patients in the treatment group were treated with Feitai Capsule, and patients in the control group did not accept any intervention. Regular observations and follow-up were performed for patients in the two groups.Main outcome measures: Analysis of variance, nonparametric test, and analysis of covariance were used to compare clinical features, amelioration of clinical symptoms, physical constitution and energy, and quality of life.
Results

There were two dropouts and 60 valid cases. The baseline characteristics of the two groups were similar. In the treatment group, symptom response and physical energy level were improved by 36.6% (Z=–2.632, P=0.008) and 26.7% (Z=–2.182, P=0.029), respectively. There was a positive correlation between these two factors (r=0.917, P<0.001). The patients in treatment group had a significantly improved quality of life after treatment. No serious adverse events were observed.
Conclusion

Feitai Capsule as maintenance treatment can improve the quality of life of the patients with mid-to-late stage NSCLC.

Key words: Non-small-cell lung carcinoma, Compound (traditional Chinese drug), Quality of life, Randomized controlled trial

Figure 1

Flow diagram of this randomized trial"

Table 1

Comparison of general information in patients between two groups"

Item n Control group (n=30) Treatment group (n=30) χ2 P
Sex
Male [Cases (%)] 39 20（66.7） 19（63.3） 0.073 0.787
Female [Cases (%)] 21 10（33.3） 11（36.7）
Age [Median (Q25, Q75)] 60 56（35, 73） 59（38, 77） – 0.523
Smoking
Smoker [Cases (%)] 32 15（50.0） 17（56.7） 0.268 0.605
Non-smoker [Cases (%)] 28 15（50.0） 13（43.3）
Stage
Ⅲa [Cases (%)] 9 4（13.3） 5（16.7） 0.271 0.602
Ⅲb [Cases (%)] 17 8（26.7） 9（30.0）
Ⅳ[Cases (%)] 34 18（60.0） 16（53.3）
KPS scale
60 [Cases (%)] 18 10（33.3） 8（26.7） 0.603 0.740
70-80 [Cases (%)] 31 14（46.7） 17（56.7）
90-100 [Cases (%)] 11 6（20.0） 5（16.7）

Table 2

Clinical symptom responses and KPS changes of patients in two groups [Cases (%)]"

Observation item Control group (n=30) Treatment group (n=30)
Symptom response
Good improvement 3（10.0） 7（23.3）
Improvement 8（26.7） 15（50.0）
Stability 12（40.0） 5（16.7）
Non-effective 7（23.3） 3（10.0）
Total improvement rate 11（36.7） 22（73.3）**
KPS scale
Good improvement 2（6.67） 5（16.7）
Improvement 6（20.0） 11（36.7）
Stable 17（56.7） 12（40.0）
Non-effective 5（16.7） 2（6.7）
Improvement rate 8（26.7） 16（53.4）*

Figure 2

Baseline changes of FACT-L scale in two groups before and after treatment Data were reprented as ?x±s, n=3. *P<0.05, vs control group."

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