Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (3): 310-317.doi: 10.3736/jcim20120310

• Original Clinical Research • Previous Articles     Next Articles

Effects of Chinese herbal medicine Bushen Huoxue Granule on quality of life of patients with Parkinson disease: a randomized, double-blinded and placebo-controlled trial

Li Min(),Yang Ming-hui,Liu Yi   

  1. Institute of Traditional Chinese Medicine, General Hospital of the People’s Liberation Army, Beijing 100853, China
  • Received:2011-07-06 Accepted:2011-08-01 Online:2012-03-20 Published:2018-10-10

BACKGROUND: The main clinical symptoms of Parkinson disease (PD) are resting tremor, muscle rigidity and bradykinesia. There is currently no effective treatment for PD, and dyskinesia symptoms affect the quality of life of patients with PD. The Chinese medicine therapy used for reinforcing kidney and activating blood circulation in treatment of PD was reported to achieve good clinical effects.
OBJECTIVE: To study the effects of Bushen Huoxue Granule, a compound traditional Chinese herbal medicine, on the quality of life of patients with PD.
DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: A total of 120 patients were enrolled from General Hospital of the People’s Liberation Army in China and divided into two groups randomly. Patients in the control group were treated with a placebo and in the treatment group with Bushen Huoxue Granule based on treating with levodopa. A double-blinded clinical trial was adopted over a 3-month treatment with a follow-up period lasting 6 months.
MAIN OUTCOME MEASURES: Unified Parkinson Disease Rating Scale Ⅱ (UPDRSⅡ), questionnaire-39 (PDQ-39) and Parkinson’s disease sleep scale (PDSS) were adopted to measure the quality of life at baseline, after 3 months of treatment and at a 6-month follow-up.
RESULTS: Bushen Huoxue Granule showed a higher efficacy than the control in improving life quality of patients with PD by improving scores of UPDRSⅡ, PDQ-39 and PDSS (P<0.05). No adverse effects were found in this trial.
CONCLUSION: Bushen Huoxue Granule can markedly improve the quality of life of patients with PD.

Key words: Parkinson disease, drugs, Chinese herbal, quality of life, randomized controlled trials, double-blinded method, placebos

Table 1

Characteristics of patients of two groups"

Group n Sex (Male/female) Age (x±s, years) Period of PD (x±s, years) H-Y stage (x±s) Levodopa (x±s, mg)
BSHXG 60 31/27 66.6±1.2 5.2±0.4 2.5±0.1 494.38±19.43
Control 60 42/20 67.3±1.2 5.1±0.5 2.3±0.1 475.00±19.43

Figure 1

Flow diagram of this randomized trial"

Table 2

UPDRSⅡ scores before and after treatment in two groups in treatment period (x±s)"

Group n UPDRSⅡ score
Before treatment One-month treatment Two-month treatment Three-month treatment
Control 51 15.41±0.90 14.98±0.87 15.02±0.90 14.71±0.87
BSHXG 55 16.49±0.87 15.98±0.84 15.38±0.87 14.62±0.84

Table 3

UPDRSⅡ scores before and after treatment in two groups in follow-up period (x±s)"

Group n UPDRSⅡ score
Before treatment After 6-month treatment After 9-month treatment
Control 51 15.41±0.90 15.22±0.81 16.88±0.83
BSHXG 55 16.49±0.87 14.13±0.77 12.86±0.78

Table 4

The changes of UPDRSⅡ scores after treatment in two groups (x±s)"

Group n The changes of UPDRSⅡ score
One-month treatment Two-month treatment Three-month treatment Six-month treatment Nine-month treatment
Control 51 2.38±0.29 1.96±0.44 2.22±0.17 1.20±0.56 0.04±0.93
BSHXG 55 2.77±0.32 2.89±0.57 4.68±0.21 5.07±0.28 8.33±0.19

Table 5

PDQ-39 scores before and after treatment in two groups (x±s)"

Group n PDQ-39 score
Before treatment After 1-month
After 2-month
After 3-month
After 6-month
After 9-month
Control 51 29.28±1.20 28.95±1.99 28.23±1.99 28.34±2.05 29.81±1.93 32.82±1.85
BSHXG 55 33.57±1.89 32.53±1.88 30.89±1.88 29.36±1.93 26.85±1.82 23.23±1.75

Table 6

The changes of PDQ-39 scores after treatment in two groups (x±s)"

Group n The changes of PDQ-39 score
After 1-month
After 2-month
After 3-month
After 6-month
After 9-month
Control 51 1.28±0.27 1.48±0.49 1.77±1.82 3.38±1.22 7.20±2.30
BSHXG 55 1.33±1.20 4.92±1.78 6.75±2.04 7.89±1.33 12.80±1.04

Table 7

PDSS scores before and after treatment in two groups in treatment period (x±s)"

Group n PDSS score
Before treatment After 1-month treatment After 2-month treatment After 3-month treatment
Control 51 98.14±4.11 101.84±3.40 103.06±3.80 102.61±3.78
BSHXG 55 89.02±3.96 94.29±3.85 99.06±3.66 101.46±3.64

Table 8

PDSS scores before and after treatment in two groups in follow-up period (x±s)"

Group n PDSS score
Before treatment After 6-month treatment After 9-month treatment
Control 51 98.14±4.11 96.69±3.35 91.49±2.97
BSHXG 55 89.02±3.96 103.76±3.17 110.56±2.80

Table 9

The changes of PDSS scores after treatment in two groups (x±s)"

Group n The changes of PDSS score
One-month treatment Two-month treatment Three-month treatment Six-month treatment Nine-month treatment
Control 51 6.07±0.45 7.29±1.44 6.12±0.97 2.12±1.39 5.13±1.47
BSHXG 55 10.70±1.01 17.96±1.38 19.27±2.09 23.18±0.24 38.21±2.16
[1] Hely MA, Morris JG, Reid WG, Trafficante R . Sydney Multicenter Study of Parkinson' disease: non- L-dopa-responsive problems dominate at 15 years. Mov Disord. 2005; 20(2):190-199.
doi: 10.1002/(ISSN)1531-8257
[2] Siderowf A, McDermott M, Kieburtz K, Blindauer K, Plumb S, Shoulson I; Parkinson Study Group . Test- retest reliability of the unified Parkinson’s disease rating scale in patients with early Parkinson's disease: results from a multicenter clinical trial. Mov Disord. 2002; 17(4) : 758-763.
doi: 10.1002/(ISSN)1531-8257
[3] Gibb WR, Lees AJ . The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1988; 51(6):745-752.
doi: 10.1136/jnnp.51.6.745
[4] Hoehn MM, Yahr MD . Parkinsonism: onset, progression and mortality. Neurology. 1967 ; 17(5) : 427-442.
doi: 10.1212/WNL.17.5.427
[5] Li M, Yang MH . Effects of strengthening kidney and activating circulation therapy on symptoms of TCM in Parkinson's patients. Zhonghua Zhong Yi Yao Za Zhi. 2010 ; 25 (12): 2346-2351. Chinese with abstract in English.
李敏, 杨明会 . 补肾活血法对帕金森患者中医证候的影响.中华中医药杂志. 2010; 25(12):2346-2351.
[6] Ministry of Health of the Peopled Republic of China. Clinical guideline of new drugs for traditional Chinese medicine (trial implementation) . Beijing: China Medical Science Press. 1993 : 91-94. Chinese.
中华人民共和国卫生部. 中药新药临床研究指导原则 (试行).北京: 中国医药科技出版社. 1993: 91-94.
[7] Bian ZX, Li YP, Moher D, Dangenais S, Liu L, Wu TX, Miao JX, Kwan AKL, Song L . Improving the quality of randomized controlled trials in Chinese herbal medicine, part I : clinical trial design and methodology. J Chin Integr Med. 2006; 4(2): 120-129. Chinese with abstract in English.
卞兆祥, 李幼平, Moher D, Dangenais S, 刘良,吴泰相,缪江霞,关家伦,宋丽 .提髙中草药随机对照试验的质量I :临床试验设计和方法学.中西医结合学报. 2006; 4(2) : 120-129.
[8] Peto V, Jenkinson C, Fitzpatrick R . PDQ-39 : a review of the development, validation and application of a Parkinson’s disease quality of life questionnaire and its associated measures. J Neurol. 1998; 245(Suppl 1):S10-S14.
doi: 10.1007/PL00007730
[9] Chaudhuri KR . Nocturnal symptom complex in PD and its management. Neurology. 2003; 61(6 Suppl 3):S17-S23.
doi: 10.1212/WNL.61.6_suppl_3.S17
[10] Den Oudsten BL, Van Heck GL, De Vries J . Quality of life and related concepts in Parkinson’s disease: a systematic review. Mov Disord. 2007 ; 22(11) : 1528-1537.
doi: 10.1002/(ISSN)1531-8257
[11] Porter B, Macfarlane R, Walker R . The frequency and nature of sleep disorders in a community-based population of patients with Parkinson's disease. Eur J Neurol. 2008; 15(1) : 50-54.
[12] Souza RG, Borges V, Silva SM, Ferraz HB . Quality of life scale in Parkinson’s disease PDQ-39 —(Brazilian Portuguese version) to assess patients with and without levodopa motor fluctuation. Arq Neuropsiquiatr. 2007; 65(3B) : 787-791.
doi: 10.1590/S0004-282X2007000500010
[13] Cornelia CL . Sleep disturbances and excessive daytime sleepiness in Parkinson disease: an overview. J Neural Transm Suppl. 2006; ( 70):349-355.
[14] Dzirasa K, Ribeiro S, Costa R, Santos LM, Lin SC, Grosmark A, Sotnikova TD, Gainetdinov RR, Caron MG, Nicolelis MA . Dopaminergic control of sleep-wake states. J Neurosci. 2006; 26(41):10577-10589.
doi: 10.1523/JNEUROSCI.1767-06.2006
[15] Yang MH, Li M, Dou YQ, Liu Y, Luo XD, Chen JZ , Shi HJ. Effects of Bushen Huoxue Granule on motor function in patients with Parkinson’s disease. J Chin Integr Med. 2010; 8(3): 231-237. Chinese with abstract in English.
杨明会, 李敏, 窦永起, 刘毅, 雒晓东, 陈建宗, 史恒军 . 补肾活血颗粒对帕金森病患者运动功能的影响.中西医结合学报. 2010; 8(3):231-237.
[1] Gerli E.G. Herr, Fábio Goulart da Silva, Francisco José Cidral-Filho, Fabricia Petronilho, Lucinéia Gainski Danielski, Mariana Pereira de Souza Goldim, Afonso Shiguemi Inoue Salgado, Franciane Bobinski, Daniel Fernandes Martins, Eliane R. Winkelmann. Effects of the use of bioceramic wraps in patients with lower limb venous ulcers: A randomized double-blind placebo-controlled trial. Journal of Integrative Medicine, 2020, 18(1): 27-.
[2] Goulnar Kasymjanova, Anh-Thi Tran, Victor Cohen, Carmela Pepe, Lama Sakr, David Small, Jason Scott Agulnik, Robert Thomas Jagoe. The use of a standardized Chinese herbal formula in patients with advanced lung cancer: A feasibility study. Journal of Integrative Medicine, 2018, 16(6): 390-395.
[3] Ching-Feng Su. Home care with acupuncture increased the quality of life in a patient with advanced cancer with neuropathic pain induced by bone metastasis: A case report. Journal of Integrative Medicine, 2018, 16(3): 208-210.
[4] Hidetoshi Mori, Hiroshi Kuge, Shunji Sakaguchi, Tim Hideaki Tanaka, Junji Miyazaki. Determination of symptoms associated with hiesho among young females using hie rating surveys. Journal of Integrative Medicine, 2018, 16(1): 34-38.
[5] Molly J. Mallory, Alexander Do, Sara E. Bublitz, Susan J. Veleber, Brent A. Bauer, Anjali Bhagra. Puncturing the myths of acupuncture. Journal of Integrative Medicine, 2016, 14(5): 311-314.
[6] Susana Seca, Sebastian Kirch, António S.Cabrita, Henry J.Greten. Evaluation of the effect of acupuncture on hand pain, functional deficits and health-related quality of life in patients with rheumatoid arthritis—A study protocol for a multicenter, double-blind, randomized clinical trial. Journal of Integrative Medicine, 2016, 14(3): 219-227.
[7] Maria T.Chao, AlexandraChang, SanjayReddy, James D.Harrison, JosephAcquah, MiriaToveg, TrilceSantana, Frederick M.Hecht. Adjunctive acupuncture for pain and symptom management in the inpatient setting: Protocol for a pilot hybrid effectiveness-implementation study. Journal of Integrative Medicine, 2016, 14(3): 228-238.
[8] Paulo AraujoDias, André Brito Bastos Guimarães, Andrea de Oliveira Albuquerque, Karoline Lucasde Oliveira, Maria Luzete CostaCavalcante, Sergio BotelhoGuimarães. Short-term complementary and alternative medicine on quality of life in women with fibromyalgia. Journal of Integrative Medicine, 2016, 14(1): 29-35.
[9] Nouran A. Aleyeidi, Khaled S. Aseri, Shadia M. Matbouli, Albaraa A. Sulaiamani, Sumayyah A. Kobeisy. Effects of wet-cupping on blood pressure in hypertensive patients: A randomized controlled trial. Journal of Integrative Medicine, 2015, 13(6): 391-399.
[10] May To, Caroline Alexander. The effects of Park sham needles: A pilot study. Journal of Integrative Medicine, 2015, 13(1): 20-24.
[11] Zhong-liang Liu, Wei-rong Zhu, Wen-chao Zhou, Hai-feng Ying, Lan Zheng, Yuan-biao Guo, Jing-xian Chen, Xiao-heng Shen. Traditional Chinese medicinal herbs combined with epidermal growth factor receptor tyrosine kinase inhibitor for advanced non-small cell lung cancer: A systematic review and meta-analysis. Journal of Integrative Medicine, 2014, 12(4): 346-358.
[12] Zhi-yi Zhou, Ling Xu, He-gen Li, Jian-hui Tian, Li-jing Jiao, Sheng-fu You, Zhi-fen Han, Yi Jiang, Hui-ru Guo​, Hui Liu​. Chemotherapy in conjunction with traditional Chinese medicine for survival of elderly patients with advanced non-small-cell lung cancer: Protocol for a randomized double-blind controlled trial. Journal of Integrative Medicine, 2014, 12(3): 175-181.
[13] Heather Ann Hausenblas, Debbie Saha, Pamela Jean Dubyak, Stephen Douglas Anton. Saffron (Crocus sativus L.) and major depressive disorder: A meta-analysis of randomized clinical trials. Journal of Chinese Integrative Medicine, 2013, 11(6): 377-383.
[14] Jian Liu, Chuan-bing Huang, Yuan Wang, Gui-qin Xu, Yuan-yuan Cheng, Yun-xia Feng, Lei Liu, Ya-jun Qi. Chinese herbal medicine Xinfeng Capsule in treatment of rheumatoid arthritis: Study protocol of a multicenter randomized controlled trial. Journal of Chinese Integrative Medicine, 2013, 11(6): 428-434.
[15] Jie Zhang, Yun-zhi Ma, Xiao-ming Shen. Evaluation on the efficacy and safety of Chinese herbal medication Xifeng Dingchan Pill in treating Parkinson’s disease: Study protocol of a multicenter, open-label, randomized active-controlled trial. Journal of Chinese Integrative Medicine, 2013, 11(4): 285-290.
Full text



[1] SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[2] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035
[3] Bing Hu , Hong-mei An , Ke-ping Shen , Qin Du. Senescence-inducing effects of Chinese herbal medicine Tenglong Buzhong Decoction on human colon carcinoma LS-174-T cells and the mechanism. Journal of Chinese Integrative Medicine, 2010, 8(11): 1048-1052
[4] Ya-bing Zhou, Jian-er Yu, Jie Wu, Li Bai, Li-li Huo, Xin-guang Zhang, Li-qing Li . Effects of Chinese herbal medicine Bushen Gubiao Recipe on toll-like receptor 4 and CD4 +CD25 +foxp3 +regulatory T cells in mice with recurrent respiratory tract infections. Journal of Chinese Integrative Medicine, 2010, 8(11): 1053-1059
[5] Chan Chen, Yong-mei Meng , Peng Zhang, Juan Wang, Hui-hui Zhao, Shu-zhen Guo , Wei Wang. Diagnosis and treatment rule of traditional Chinese medicine for syndrome factors of chronic congestive heart failure: a study based on Shannon entropy method. Journal of Chinese Integrative Medicine, 2010, 8(11): 1080-1084
[6] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[7] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[8] Ming-qing Wei , Jin-zhou Tian , Jing Shi , Fu-yun Ma , Ying-chun Miao , Yong-yan Wang. Effects of Chinese medicine for promoting blood circulation and removing blood stasis in treating patients with mild to moderate vascular dementia: a randomized, double-blind and parallel-controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(11): 1240-1246
[9] Nian-hong Wang , Jun-tao Yan , Wu-quan Sun , Yong-shan Hu , Jun Xia , Li-cheng Wei , Jie Jia , Gui-lin Ouyang , Yong He , Yan-ming Guo , Jie Xu . Effects of early application of Tuina treatment on quadriceps surface myoelectricity in patients after total knee arthroplasty: a randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(11): 1247-1253
[10] Ying Xu , Chang-chun Zeng , Xiu-yu Cai , Rong-ping Guo , Guang Nie , Ying Jin. Chromaticity and optical spectrum colorimetry of the tongue color in different syndromes of primary hepatic carcinoma. Journal of Chinese Integrative Medicine, 2012, 10(11): 1263-1271