Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (3): 215-219.doi: 10.3736/jcim20100303
• Original Clinical Research • Previous Articles Next Articles
Discussion of the correlation between phlegm and tumor microenvironment
Ci-an Zhang
,Pin-kang Wei, Yong-jin Li
- Department of Traditional Chinese Medicine, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
| [1] |
Gatenby RA, Gawlinski ET, Gmitro AF, Kaylor B, Gillies RJ . Acid-mediated tumor invasion: a multidisciplinary study[J]. Cancer Res, 2006,66(10):5216-5223
doi: 10.1158/0008-5472.CAN-05-4193 |
| [2] |
van den Beucken T, Ramaekers CH, Rouschop K, Koritzinsky M, Wouters BG . Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment[J]. Radiother Oncol, 2009,92(3):437-442
doi: 10.1016/j.radonc.2009.06.018 |
| [3] |
Lee HC, Wei YH . Mitochondrial DNA instability and metabolic shift in human cancers[J]. Int J Mol Sci, 2009,10(2):674-701
doi: 10.3390/ijms10020674 |
| [4] |
Gatenby RA, Gillies RJ . Glycolysis in cancer: a potential target for therapy[J]. Int J Biochem Cell Biol, 2007,39(7-8):1358-1366
doi: 10.1016/j.biocel.2007.03.021 |
| [5] | Harguindey S, Orive G, Luis Pedraz J, Paradiso A, Reshkin SJ . The role of pH dynamics and the Na+/H+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin — one single nature[J]. Biochim Biophys Acta, 2005,1756(1):1-24 |
| [6] |
Reshkin SJ, Bellizzi A, Caldeira S, Albarani V, Malanchi I, Poignee M, Alunni-Fabbroni M, Casavola V, Tommasino M . Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes[J]. FASEB J, 2000,14(14):2185-2197
doi: 10.1096/fj.00-0029com |
| [7] |
Hopfl G, Ogunshola O, Gassmann M . HIFs and tumors — causes and consequences[J]. Am J Physiol Regul Integr Comp Physiol, 2004,286(4):R608-R623
doi: 10.1152/ajpregu.00538.2003 |
| [8] |
Favaro E, Nardo G, Persano L, Masiero M, Moserle L, Zamarchi R, Rossi E, Esposito G, Plebani M, Sattler U, Mann T, Mueller-Klieser W, Ciminale V, Amadori A, Indraccolo S . Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death[J]. Am J Pathol, 2008,173(4):1186-1201
doi: 10.2353/ajpath.2008.071183 |
| [9] |
Otrock ZK, Hatoum HA, Awada AH, Ishak RS, Shamseddine AI . Hypoxia-inducible factor in cancer angiogenesis: structure, regulation and clinical perspectives[J]. Crit Rev Oncol Hematol, 2009,70(2):93-102
doi: 10.1016/j.critrevonc.2009.01.001 |
| [10] |
Kizaka-Kondoh S, Tanaka S, Harada H, Hiraoka M . The HIF-1-active microenvironment: an environmental target for cancer therapy[J]. Adv Drug Deliv Rev, 2009,61(7-8):623-632
doi: 10.1016/j.addr.2009.01.006 |
| [11] |
Marín-Hernández A, Gallardo-Pérez JC, Ralph SJ, Rodríguez-Enríquez S, Moreno-Sánchez R . HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms[J]. Mini Rev Med Chem, 2009,9(9):1084-1101
doi: 10.2174/138955709788922610 |
| [12] |
Semenza GL . Regulation of cancer cell metabolism by hypoxia-inducible factor 1[J]. Semin Cancer Biol, 2009,19(1):12-16
doi: 10.1016/j.semcancer.2008.11.009 |
| [13] |
Winum JY, Rami M, Scozzafava A, Montero JL, Supuran C . Carbonic anhydrase Ⅸ: a new druggable target for the design of antitumor agents[J]. Med Res Rev, 2008,28(3):445-463
doi: 10.1002/(ISSN)1098-1128 |
| [14] | Wei PK, Xu L, Sun DZ, Shi J, Qin ZF, Lu Y . The correlation between phlegm and gastric carcinoma[J]. Zhong Yi Za Zhi, 2006,47(3):166-168 |
| 魏品康, 许玲, 孙大志, 施俊, 秦志丰, 陆烨 . 痰与胃癌发生发展的关系[J]. 中医杂志, 2006,47(3):166-168 | |
| [15] | Li YY . Phlegm and cancer[J]. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi, 1995,1(4):46-47 |
| 李以义 . 痰浊与癌症[J]. 中国中医基础医学杂志, 1995,1(4):46-47 | |
| [16] | Wang J, Xu ZW, Yan C, Pan Y . Mechanism of phlegm syndrome from pathological changes of mucus-like materials[J]. Shanghai Zhong Yi Yao Za Zhi, 2005,39(10):44-45 |
| 王剑, 徐志伟, 严灿, 潘毅 . 从黏液类物质病理改变探讨痰证机理[J]. 上海中医药杂志, 2005,39(10):44-45 | |
| [17] | Wang J, Yan C, Deng ZY . Mechanism of phlegm syndrome from adhesion molecule metabolic disorders[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2000,20(4):296-297 |
| 王剑, 严灿, 邓中炎 . 从粘附分子代谢失常探讨痰证机理[J]. 中国中西医结合杂志, 2000,20(4):296-297 | |
| [18] | Zhang S, Wei PK, He J, Xiao Y, Chen GQ, Gu JZ, Lin HM, Xu L . Effect of Jinlongshe Recipe on metastasis and expression of various adhesion molecules of orthotopic transplanted gastric carcinoma MKN-45 in nude mice[J]. Zhong Liu, 2006,26(6):519-524 |
| 张申, 魏品康, 何金, 肖艳, 陈国强, 顾坚忠, 林晖明, 许玲 . 金龙蛇方对人胃癌MKN-45裸小鼠原位移植瘤生长转移及多种粘附分子蛋白表达的影响[J]. 肿瘤, 2006,26(6):519-524 | |
| [19] | Zhou JL . Discussion of the correlations between mitochondria and spleen[J]. Liaoning Zhong Yi Za Zhi, 2006,33(3):287 |
| 周俊亮 . 中医脾与线粒体关系探讨[J]. 辽宁中医杂志, 2006,33(3):287 | |
| [20] | Song YF, Liu YZ, Ji AD, Liu J . Discussion of the correlations between mitochondria and spleen controlling transportation and transformation[J]. Liaoning Zhong Yi Za Zhi, 2007,34(1):23-24 |
| 宋雅芳, 刘友章, 姬爱冬, 刘静 . 脾主运化与细胞线粒体相关再探析[J]. 辽宁中医杂志, 2007,34(1):23-24 | |
| [21] | Xu RH, Pelicano H, Zhou Y, Carew JS, Feng L, Bhalla KN, Keating MJ, Huang P . Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia[J]. Cancer Res, 2005,65(2):613-621 |
| [22] | Sun YL, Hu YD . Progress in study of mitochondrial DNA correlating with carcinoma[J]. Zhonghua Zhong Liu Fang Zhi Za Zhi, 2006,13(12):951-955 |
| 孙玉兰, 胡义德 . 线粒体DNA与肿瘤关系的研究进展[J]. 中华肿瘤防治杂志, 2006,13(12):951-955 | |
| [23] | Wei PK, Sun DZ, Xu L, Qin ZF, Shi J, Zhang S, Peng HD, Lu Y, Li XY, Xiao Y, Xiu LJ, Ju DW, Yu S, Wu F, Li J, Chen TC . The correlations between gastric carcinoma and phlegm nature[J]. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi, 2009,15(2):104-106 |
| 魏品康, 孙大志, 许玲, 秦志丰, 施俊, 张申, 彭海东, 陆烨, 李相勇, 肖艳, 修丽娟, 巨大维, 俞珊, 武峰, 李峻, 陈天池 . 胃癌与恶痰内涵关系[J]. 中国中医基础医学杂志, 2009,15(2):104-106 | |
| [24] | Zhao YJ, Wang L, Hou L, Zhang XN, Ji ZQ, Yue W . A study on the anti-tumor effect of polysaccharides from Pinellia tuber[J]. Zhongguo Yao Li Xue Tong Bao, 2006,22(3):368-371 |
| 赵永娟, 王蕾, 侯琳, 张向农, 吉中强, 岳旺 . 半夏多糖抗肿瘤作用研究[J]. 中国药理学通报, 2006,22(3):368-371 | |
| [25] | Yang ZH, Yin JY, Wei ZR, Yan WQ . A study on the effects and mechanism of Arisaema extract in inducing hepatocellular carcinoma(SMMC-7721) cell apoptosis[J]. Zhongguo Lao Nian Xue Za Zhi, 2007,27(2):142-144 |
| 杨宗辉, 尹建元, 魏征人, 颜炜群 . 天南星提取物诱导人肝癌SMMC-7721细胞凋亡及其机制的实验研究[J]. 中国老年学杂志, 2007,27(2):142-144 |
| [1] | Yan-bo Zhu , Hideki Origasa, Xiao-xia Luo, Yang-yang Wang , Jie Di , Lin Lin. Responsiveness of three subjective report of outcome measures for chronic heart failure. Journal of Chinese Integrative Medicine, 2012, 10(12): 1375-1381. |
| [2] | Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228. |
| [3] | Li Cai-hong, Qiu Qing-hua, Wu Xing-wei, Gong Yuan-yuan, Xie Zheng-gao, Song Yi, Gu Qing. Chinese herbal medicine Lingqi Huangban Granule protects retinal pigment epithelial cells against oxidative stress-induced injury in vitro. Journal of Chinese Integrative Medicine, 2012, 10(1): 85-90. |
| [4] | Lei Wang, Li-heng Guo, Jun Zhang, Xu-jie Zhao, Min-zhou Zhang. A study protocol for clinical pathways based on integrative medicine for patients with acute myocardial infarction. Journal of Chinese Integrative Medicine, 2011, 9(7): 725-731. |
| [5] | Li-xin Lang, Xiao-bo Wang, Wei Hou. Successful treatment of adult idiopathic pulmonary hemosiderosis with integrated traditional Chinese and Western medicine: A report of one case. Journal of Chinese Integrative Medicine, 2011, 9(5): 531-532. |
| [6] | Hong-cai Shang, Jin-ling Huang, Li-wei Han, Ling-peng Pei, Lin Guo, Na Lin, Chang-en Wang . Applications and approved projects on traditional Chinese medicine in National Natural Science Foundation of China in 2010. Journal of Chinese Integrative Medicine, 2011, 9(10): 1045-1050. |
| [7] | Zi-hui Li, JianWang, Rong-lin Cai. Progress in research on correlation between dampness disease and aquaporin. Journal of Chinese Integrative Medicine, 2011, 9(1): 5-10. |
| [8] | XQ Yue. Towards better understanding the definition of cancerous toxin. Journal of Chinese Integrative Medicine, 2010, 8(9): 829-831. |
| [9] | the Project Group for Demonstration Study of Syndrome Differentiation Protocol Effect Evaluation of Acute Ischemic Stroke, Yan Huang, Jian-wen Guo. Outcome and safety assessment of an herbal medicine treatment protocol for yin pattern of acute ischemic stroke. Journal of Chinese Integrative Medicine, 2010, 8(5): 417-426. |
| [10] | Hao Li , Long-tao Liu, Wen-ming Zhao, Jian-gang Liu, Ming-jiang Yao, Yong-xiang Han, Yan-peng Shen, Xing-dong Liu, Li Liu, Xue-mei Wang, Lin-lin Cai, Jie Guan. Traditional Chinese versus integrative treatment in elderly patients with isolated systolic hypertension: A multicenter, randomized, double-blind controlled trial. Journal of Chinese Integrative Medicine, 2010, 8(5): 410-416. |
| [11] | Ni-da Cao, Ai-guang Zhao, Jin-kun Yang. Survival time of advanced gastric cancer patients treated with integrated traditional Chinese and Western medicine therapy. Journal of Chinese Integrative Medicine, 2010, 8(2): 116-120. |
| [12] | Xue-mei You, Xiao Qin, Zhi-yong Dong, Guan-liang Wang. Integrated traditional Chinese and Western medicine versus Western medicine in treatment of arteriosclerosis obliterans: A systematic review of randomized controlled trials. Journal of Chinese Integrative Medicine, 2010, 8(10): 917-927. |
| [13] | Hao Li, Long-tao Liu. Considerations about treatment programs of elderly patients with hypertension. Journal of Chinese Integrative Medicine, 2009, 7(7): 607-610. |
| [14] | Ke-ji Chen, Yue-rong Jiang. Current status and problems in developing clinical guidelines for Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2009, 7(4): 301-305. |
| [15] | Ying-chun Miao , Jin-zhou Tian , Jing Shi , Min Mao , Xiao-dong Zhao , Li-yan Fang , Chui-you Zeng , Jian-ping Liu , Zhi-liang Wang , Xiao-bin Li. Correlation between cognitive functions and syndromes of traditional Chinese medicine in amnestic mild cognitive impairment. Journal of Chinese Integrative Medicine, 2009, 7(3): 205-211. |