SUBSCRIBE
Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (10): 917-927.doi: 10.3736/jcim20101003

• Systematic Review • Previous Articles     Next Articles

Integrated traditional Chinese and Western medicine versus Western medicine in treatment of arteriosclerosis obliterans: A systematic review of randomized controlled trials

 Xue-mei Youa, Xiao Qina, Zhi-yong Dongb, Guan-liang Wangb   

  1. a Department of Hepatobiliary Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi Province, China
    b Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received:2010-03-09 Accepted:2010-05-07 Online:2010-10-20 Published:2010-10-15

RichHTML

3

PDF (PC)

125

Like

Background

The conventional therapy for arteriosclerosis obliterans (ASO) is Western medicine. However, it has some adverse effects and does not respond to some patients, and it is also very expensive.
Objective

To evaluate the efficacy of integrated traditional Chinese (TCM) and Western medicine (WM) in treatment of ASO.
Search strategy

Electronic and manual searches were conducted and the searches ended on May 20, 2009.
Inclusion criteria

We included randomized controlled trials (RCT) evaluating integrated TCM and WM (as treatment group) versus WM used alone (as control group), and no language limits were set.
Data extraction and analysis

Selection of trials for inclusion, assessment for methodological quality, data extraction and data syntheses were conducted according to protocol of a Cochrane systematic review by the authors.
Results

Thirteen RCT were included, which encompassed a total of 968 patients. The results showed that all of the 13 included trials did not report mortality rate of ASO. The studies displayed that the amputation rate in the treatment group was lower than that in the control group, but there was no statistical significance. Ten studies adopted inefficiency analysis and 2 of them showed that the ineffective rate in the treatment group was lower than that in the control group, and the relative risk (RR) and 95% CI were 0.36 [0.13, 0.99]. We performed descriptive analysis on other 8 studies; analyses of secondary outcomes such as intermittent claudication, ankle brachial index, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) showed that integrated TCM and WM therapy was more effective than WM treatment alone; one study showed that WM was better than integrated TCM and WM therapy in decreasing the content of fibrinogen. All of the included trials did not report any critical adverse reactions occurred in the treatment group.
Conclusion

The current evidence shows that integrated TCM and WM therapy is safe and effective in treating ASO, and tends to reduce amputation rate, improve intermittent claudication, decrease the levels of fibrinogen, HDL and LDL, and increase ankle brachial index, without obvious adverse reactions. Due to the low methodological quality of trials included, more prospective, multicenter, large-scale, high-quality RCTs are needed.

Key words: Integrated traditional Chinese and Western medicine, Arteriosclerosis obliterans, Systematic review, Meta-analysis

Figure 1

Flow diagram of literature retrieval and selection"

Table 1

Characteristics of included studies"

Study ID Participant [Cases(male/female)] Intervention Treatment course Outcome
Control Treatment Control Treatment
Li 2003[14] 92 (80/12) 92 (80/12) Buffered aspirin
tablet and urokinase		 Kangmai Injection
plus control
interventions		 30 days Total effective rate and immunity erythrocyte index
Zhao 2008[15] 37 (33/4) 43 (38/5) Lovastatin, aspirin,
and prostaglandin E1		 Huoxue Wenmai
Tang plus control
interventions		 180 days Clinical symptom score; total
effective rate, blood lipid,
hemorheology, colour Doppler, and adverse reactions
Li 2004[16] 28 (27/1) 28 (26/2) Vasodilation,
thrombolysis, and
prescriptions for
lowering blood lipids and sugar		 Gubu Tang and
Danggui Sini Tang
plus control
interventions		 15-30 days Total effective rate
Wang 1999[17] 30 (25/5) 30 (25/5) Prostaglandin E1,
venoruton and
low-molecular-weight dextran		 Compound traditional
Chinese herbal
medicine plus control interventions		 60-90 days Total effective rate, and the
levels of endothelin-1, nitric
oxide, apolipoprotein and HDL
Mou 2002[18] 36 (26/10) 56 (48/8) Prostaglandin E1,
venoruton and
low-molecular-weight dextran		 Wentong Tang plus
control interventions		 60-90 days Total effective rate, effective
rate of different stage and
grade, main symptoms and
signs, hemorheology, ABI, and
skin temperature
Wu 2008[19] 32 (26/6) 32 (27/5) Prostaglandin E1 Wenjing Fumai Tang
plus control
interventions		 66 days Total effective rate, improvement of inner diameter, plaque area and intima thickness of vessel, and clinical symptom score
Li 2008[20] 28 (20/8) 30 (22/8) Prostaglandin E1 Danhong Injection
plus control
interventions		 14 days Total effective rate,
hemorheology, Doppler of
femoral artery, and adverse
reactions
Wang 2008[21] 36 (no
report of
the gender
ratio)		 31 (no
report of
the gender ratio)		 Defibrase, aspirin,
lovastatin and
pentoxifylline		 Danhong Injection
plus control
interventions		 10 days Total effective rate,
hemorheology, and adverse
reactions
Wang 2008[22] 15 (11/4) 17 (12/5) Warfarin Liuchong Capsule
plus control
interventions		 180 days Incidence rate of intermittent
claudication, amputation rate,
hemorheology, patency rate of
artificial blood vessel one year
after operation, and adverse
reactions
Zhuang 2007[23] 18 (no
report of
the gender
ratio)		 20 (no
report of
the gender
ratio)		 Low-molecular-weight heparin, and
warfarin		 Refined Xuefu
Capsule plus control
interventions		 90 days Clinical effects, and patency
rate of artificial blood vessel one
year after operation
Chan 2008[24] 58 (no
report of
the gender
ratio)		 63 (no
report of
the gender
ratio)		 Prescriptions for
controlling plasma
glucose, vasodilators, and debridement
therapy		 Qizhi Gubu Capsule
plus control
interventions		 28-84 days Total effective rate, blood lipid,
hemorheology, and adverse
reactions
Mao 2003[25] 30 (24/6) 30 (25/5) Prescriptions for
controlling plasma
glucose and actovegin		 Honghua Injection
plus control
interventions		 20 days Total effective rate, blood lipid
and plasma glucose,
hemorheology, and adverse
reactions
Han 2007[26] 28 28 Prescriptions for
controlling plasma
glucose, aspirin and
prostaglandin E1		 Leigongteng powder
plus control
interventions		 84 days Symptoms and signs, lesion
nature of crura vesse, and the
levels of APO and HDL

Table 2

Quality assessment of included studies"

Study ID Method of
randomization		 Allocation
concealment		 Blinding Incomplete
outcome data
addressed		 Selective
reporting		 Other bias
Li 2003[14] Random number
table		 Unclear Unclear Unclear Yes Unclear
Zhao 2008[15] Drawing lots Yes Unclear Unclear Yes Unclear
Li 2004[16] Drawing lots Unclear Unclear Unclear Yes Unclear
Wang 1999[17] Unclear Unclear Unclear Unclear Yes Unclear
Mou 2002[18] Unclear Unclear Unclear Unclear Yes Unclear
Wu 2008[19] Computer
randomization		 Unclear Single blind
method		 Unclear Yes Unclear
Li 2008[20] Unclear Unclear Unclear Unclear Yes Unclear
Wang 2008[21] Unclear Unclear Unclear Unclear Yes Unclear
Wang 2008[22] Drawing lots Unclear Unclear Unclear Yes Unclear
Zhuang 2007[23] Computer
randomization		 Unclear Unclear Unclear Yes Unclear
Chan 2008[24] Unclear Unclear Unclear Unclear Yes Unclear
Mao 2003[25] Unclear Unclear Unclear Unclear Yes Unclear
Han 2007[26] Unclear Unclear Unclear Unclear Yes Unclear

Figure 2

Descriptive analysis of amputation rates in integrated traditional Chinese and Western medicine group and Western medicine group"

Figure 3

Meta-analysis of inefficiency rates in integrated traditional Chinese and Western medicine group and Western medicine group"

Figure 4

Descriptive analysis of inefficiency rates in integrated traditional Chinese and Western medicine group and Western medicine group"

[1] Vascular Surgery Group of Surgery Branch of Chinese Medical Association. Guideline for treatment of lower extremity arteriosclerosis obliterans[J]. Zhongguo Shi Yong Wai Ke Za Zhi, 2008,28(11):923-924
中华医学会外科学分会血管外科学组. 下肢动脉硬化性闭塞症治疗指南[J]. 中国实用外科杂志, 2008,28(11):923-924
[2] Management of peripheral arterial disease(PAD).TransAtlantic Inter-Society Consensus(TASC)[J].Eur J Vasc Endovasc Surg, 2000, 19(Suppl A):Si-xxviii, S1-250
doi: 10.1016/S0741-5214(00)81002-2
[3] Ouriel K . Peripheral arterial disease[J]. Lancet, 2001,358(9289):1257-1264
doi: 10.1016/S0140-6736(01)06351-6
[4] Clement DL . Medical treatment of peripheral artery occlusive disease(PAOD)[J]. Acta Chir Belg, 2000,100(5):190-193
doi: 10.1038/sj.bdj.4800777a pmid: 11143319
[5] Paumier A, Abraham P, Mahé G, Maugin E, Enon B, Leftheriotis G, Picquet J . Functional outcome of hypogastric revascularisation for prevention of buttock claudication in patients with peripheral artery occlusive disease[J]. Eur J Vasc Endovasc Surg, 2010,39(3):323-329
doi: 10.1016/j.ejvs.2009.10.009
[6] Steg PG, Tanlil O, Aubailly N, Caillaud JM, Dedieu JF, Berthelot K, Roux AL, Feldman L, Perricaudet M, Denèfle P, Branellec D . Reduction of restenosis after angioplasty in an atheromatous[J]. Circulation, 1997,96(2):408-411
doi: 10.1161/01.CIR.96.2.408
[7] Shang DJ, Wang JJ, Zhang BG. Peripheral vascular surgery of integrated traditonal Chinese and Western medicine[M]. Beijing: People’s Medical Publishing House,2004: 272-274
尚德俊, 王嘉桔, 张柏根 . 中西医结合周围血管疾病学[M]. 北京: 人民卫生出版社,2004: 272-274
[8] Tian DL. Traditional Chinese internal medicine[M]. Beijing: People’s Medical Publishing House,2002: 168-170
田德禄 . 中医内科学[M]. 北京: 人民卫生出版社,2002: 168-170
[9] Hou YF, Chen BN, Zhou T, Jin X, Zhou LL, Qin HS, Liu CM, Li ZH, Han QC, Liu M, Liu HP, Zhao XD . Clinical research on arteriosclerosis obliterans treated by Mairong Mixtrure[J]. Zhongguo Zhong Xi Yi Jie He Wai Ke Za Zhi, 1999,5(2):70
侯玉芬, 陈柏楠, 周涛, 金星, 周黎丽, 秦红松, 刘春梅, 李昭辉, 韩秋成, 刘明, 刘洪普, 赵绚德 . 脉荣合剂治疗肢体动脉硬化性闭塞症临床研究[J]. 中国中西医结合外科杂志, 1999,5(2):70
[10] Dong JS, Wang CX, Hang LN, Wu XZ . Observation on effect of integrated Chinese and Western medicine treatment in patients with atherosclerosis obliterans[J]. Zhongguo Zhong Xi Yi Jie He Wai Ke Za Zhi, 1999,5(3):133-136
董均树, 王春喜, 韩丽娜, 吴咸中 . 中西医结合治疗动脉粥样硬化闭塞症疗效观察[J]. 中国中西医结合外科杂志, 1999,5(3):133-136
[11] Cui GR . Necessity and feasibility of integrated traditional Chinese and Western medicine therapy in treatment of arteriosclerosis obliterans[J]. Zhongguo Zhong Xi Yi Jie He Wai Ke Za Zhi, 2005,11(2):91-92
崔公让 . 动脉硬化闭塞症中西医结合治疗的必然性与可行性[J]. 中国中西医结合外科杂志, 2005,11(2):91-92
[12] Committee of Peripheral Vascular Disease, China Society of Integrated Traditional Chinese and Western Medicine.Criteria for diagnosis and therapeutic effect evaluation of peripheral vascular diseases[M].Fuzhou: The Fourth National Integrated Chinese and Western Medicine Treatment of Vascular Diseases: Academic Conference Proceedings, 1995: 10
中国中西医结合学会周围血管疾病专业委员会 .周围血管疾病诊断及疗效标准[M].福州: 全国第4届中西医结合治疗周围血管疾病学术会议论文集, 1995: 10
[13] Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.0.1 [updated September 2008
[14] Li LG, Xu H, Zhao G, Wu MY, Li RH . Kangmai Injection combined with Western medicine in treatment of 92 cases of arteriosclerosis obliterans[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2003,23(7):555
李令根, 徐恒, 赵钢, 吴明远, 李日恒 . 康脉注射液结合西药治疗动脉硬化闭塞症92例[J]. 中国中西医结合杂志, 2003,23(7):555
[15] Zhao F . Integrated traditional Chinese and Western medicine in treatment of 43 cases of arteriosclerosis obliterans[J]. Xin Zhong Yi, 2008,40(2):47-49
doi: 10.3969/j.issn.0256-7415.2008.02.027
赵峰 . 中西医结合治疗闭塞性动脉硬化症43例临床观察[J]. 新中医, 2008,40(2):47-49
doi: 10.3969/j.issn.0256-7415.2008.02.027
[16] Li C, Wen Z . Integrated traditional Chinese and Western medicine in treatment of 28 cases of arteriosclerosis obliterans[J]. Jilin Zhong Yi Yao, 2004,24(4):30
李春, 温忠 . 中西医结合治疗动脉硬化性闭塞症28例[J]. 吉林中医药, 2004,24(4):30
[17] Wang CX, Qi QH, Wu XZ . Observation on effect of integrated Chinese and Western medicine in treating patients with peripheral atherosclerosis[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 1999,19(6):332-334
doi: 10.7661/CJIM.1999.6.332
王春喜, 齐清会, 吴咸中 . 中西医结合治疗周围动脉粥样硬化闭塞症疗效观察[J]. 中国中西医结合杂志, 1999,19(6):332-334
doi: 10.7661/CJIM.1999.6.332
[18] Mou X, Ma GL . Clinical research of Wentong Tang in treatment of arteriosclerosis obliterans[J]. Beijing Zhong Yi Za Zhi, 2002,21(6):341-343
doi: 10.3969/j.issn.1674-1307.2002.06.008
牟新, 马国玲 . 温通汤治疗动脉硬化性闭塞症的临床研究[J]. 北京中医杂志, 2002,21(6):341-343
doi: 10.3969/j.issn.1674-1307.2002.06.008
[19] Wu YQ . Clinical observation of Wenjing Fumai Tang in treatment of 32 cases of arteriosclerosis obliterans in stage Ⅱ[J]. Beijing Zhong Yi Yao, 2008,27(6):453-455
吴玉泉 . 温经复脉汤治疗Ⅱ期闭塞性动脉硬化症32例临床观察[J]. 北京中医药, 2008,27(6):453-455
[20] Li F, Liu FQ, Tang Y, Zhang HF . Clinical research of Danhong Injection plus prostacyclin E1 in treatment of lower extremity arteriosclerosis obliterans[J]. Zhong Xi Yi Jie He Xin Nao Xue Guan Bing Za Zhi, 2008,6(8):987-988
doi: 10.3969/j.issn.1672-1349.2008.08.057
李峰, 刘凤芹, 唐勇, 张华芳 . 丹红注射液联合前列环素E1治疗下肢动脉硬化闭塞症疗效观察[J]. 中西医结合心脑血管病杂志, 2008,6(8):987-988
doi: 10.3969/j.issn.1672-1349.2008.08.057
[21] Wang NM, Zhao XL, Jin ML . Clinical observation of defibrase in treatment of lower extremity arteriosclerosis obliterans[J]. Zhongguo Wu Zhen Xue Za Zhi, 2008,8(1):677-678
doi: 10.3969/j.issn.1009-6647.2008.01.050
王乃梅, 赵晓玲, 金明磊 . 降纤酶治疗下肢动脉硬化闭塞症的临床观察[J]. 中国误诊学杂志, 2008,8(1):677-678
doi: 10.3969/j.issn.1009-6647.2008.01.050
[22] Wang LM, Wang TN, Zhao HF, Zhang CY . Clinical observation of Chinese herbal medicine in treatment of postoperation of vascular prosjournal by pass for lower extremity arteriosclerosis obliterans[J]. Liaoning Zhong Yi Za Zhi, 2008,35(5):729-730
doi: 10.3969/j.issn.1000-1719.2008.05.046
王立敏, 王铁牛, 赵红放, 张春彦 . 中药治疗下肢动脉硬化闭塞症人工血管旁路术后疗效观察[J]. 辽宁中医杂志, 2008,35(5):729-730
doi: 10.3969/j.issn.1000-1719.2008.05.046
[23] Zhuang BX, Ma LB, Yu CL, Zhang T, Yang S, Shi B, Shi DZ . Effects of Refined Xuefu Capsule on vascular patency rate after femoral-popliteal by pass[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2007,27(1):69-71
doi: 10.3321/j.issn:1003-5370.2007.01.016
庄百溪, 马鲁波, 于春利, 张童, 杨森, 石波, 史大卓 . 精制血府胶囊对股腘动脉人工血管旁路术后通畅率的影响[J]. 中国中西医结合杂志, 2007,27(1):69-71
doi: 10.3321/j.issn:1003-5370.2007.01.016
[24] Chan SL, Li SJ, Li SL, Run JM, Liu LH, Sun FQ, Kong HY, Cui MX . Clinical observation of Qizhi Gubu Capsule in treatment of 63 cases of arteriosclerosis obliterans complicated with diabetes[J]. Xin Zhong Yi, 2008,40(6):23-24
doi: 10.3969/j.issn.0256-7415.2008.06.015
缠双鸾, 李素君, 李书林, 润景谟, 刘丽华, 孙凤芹, 孔海燕, 崔茂香 . 芪蛭顾步胶囊治疗糖尿病并发动脉硬化闭塞症63例疗效观察[J]. 新中医, 2008,40(6):23-24
doi: 10.3969/j.issn.0256-7415.2008.06.015
[25] Mao LH . Integrated traditional Chinese and Western medicine in treatment of 60 cases of arteriosclerosis obliterans complicated with diabetes[J]. Zhong Xi Yi Jie He Xin Nao Xue Guan Bing Za Zhi, 2003,1(7):393-394
doi: 10.3969/j.issn.1672-1349.2003.07.011
毛林华 . 中西医结合治疗糖尿病周围动脉粥样硬化闭塞症60例疗效观察[J]. 中西医结合心脑血管病杂志, 2003,1(7):393-394
doi: 10.3969/j.issn.1672-1349.2003.07.011
[26] Han JQ, Zhang YN, Zhao TZ, Zhang JG, Hu SQ, Fang LH . Tripterygium wilfordii in treatment of lower extremity arteriosclerosis obliterans complicated with diabetes[J]. Shi Yong Tang Niao Bing Za Zhi, 2007,3(1):50-51
韩建勤, 张彦宁, 赵通洲, 张建刚, 胡守琪, 方利华 . 雷公藤治疗糖尿病下肢动脉硬化闭塞症[J]. 实用糖尿病杂志, 2007,3(1):50-51
[27] Picquet J, Jacquinandi V, Saumet JL, Leftheriotis G, Enon B, Abraham P . Systematic diagnostic approach to proximal-without-distal claudication in a vascular population[J]. Eur J Intern Med, 2005,16(8):575-579
doi: 10.1016/j.ejim.2005.06.013 pmid: 16314239
[28] Fu JY . Current status of research on complementary and alternative medicine in the United States: in comparison with that on traditional Chinese medicine in China[J]. J Chin Integr Med, 2008,6(6):551-554
傅俊英 . 美国补充替代医学的科研现状及其与中国中医药研究的比较[J]. 中西医结合学报, 2008,6(6):551-554
[29] Liao X, Xie YM . Application of semi-structured and in-depth interview on optimization of clinical research program in traditional Chinese medicine[J]. J Chin Integr Med, 2009,7(4):309-314
doi: 10.3736/jcim20090403
廖星, 谢雁鸣 . 基于半结构深度访谈法探讨中医临床研究的方案优化[J]. 中西医结合学报, 2009,7(4):309-314
doi: 10.3736/jcim20090403
[30] Wu TX, Li YP, Bian ZX, Li TQ, Li J, Dagenais S, Moher D, CONSORT for TCM Group .Consolidated standards for reporting trials of traditional Chinese medicine(CONSORT for TCM)[J]. Zhongguo Xun Zheng Yi Xue Za Zhi, 2007,7(8):601-605
doi: 10.3969/j.issn.1672-2531.2007.08.013
吴泰相, 李幼平, 卞兆祥, 李廷谦, 李静, Dagenais S, Moher D . 中医药临床随机对照试验报告规范(征求意见稿)[J]. 中国循证医学杂志, 2007,7(8):601-605
doi: 10.3969/j.issn.1672-2531.2007.08.013
[1] Ming-min Xu, Pei Guo, Qing-yu Ma, Xuan Zhou, Yu-long Wei, Lu Wang, Yue Chen, Yu Guo. Can acupuncture enhance therapeutic effectiveness of antidepressants and reduce adverse drug reactions in patients with depression? A systematic review and meta-analysis. Journal of Integrative Medicine, 2022, 20(4): 305-320.
[2] Ting-ting Lu, Cun-cun Lu, Mei-xuan Li, Li-xin Ke, Hui Cai, Ke-hu Yang. Reporting and methodological quality of meta-analyses of acupuncture for patients with migraine: A methodological investigation with evidence map. Journal of Integrative Medicine, 2022, 20(3): 213-220.
[3] Witoo Dilokthornsakul, Ramanya Kosiyaporn, Rattanamanee Wuttipongwaragon, Piyameth Dilokthornsakul. Potential effects of propolis and honey in COVID-19 prevention and treatment: A systematic review of in silico and clinical studies. Journal of Integrative Medicine, 2022, 20(2): 114-125.
[4] Deng-chao Wang, Miao Yu, Wen-xian Xie, Li-yan Huang, Jian Wei, Yue-hua Lei. Meta-analysis on the effect of combining Lianhua Qingwen with Western medicine to treat coronavirus disease 2019. Journal of Integrative Medicine, 2022, 20(1): 26-33.
[5] Jun-peng Yao, Li-ping Chen, Xian-jun Xiao, Ting-hui Hou, Si-yuan Zhou, Ming-min Xu, Kai Wang, Yu-jun Hou, Lin Zhang, Ying Li. Effectiveness and safety of acupuncture for treating functional constipation: An overview of systematic reviews. Journal of Integrative Medicine, 2022, 20(1): 13-25.
[6] Yang-hao-tian Wu, Wen-bo He, Yin-yan Gao, Xue-mei Han. Effects of traditional Chinese exercises and general aerobic exercises on older adults with sleep disorders: A systematic review and meta-analysis. Journal of Integrative Medicine, 2021, 19(6): 493-502.
[7] Yi Yuan, Rui-Ting Wang, Jun Xia, Hui-Juan Cao. Interventions for preventing influenza: an overview of Cochrane systematic reviews and a Bayesian network meta-analysis. Journal of Integrative Medicine, 2021, 19(6): 503-514.
[8] Meng-zhu Zhao, Chen Zhao, Shuang-shuang Tu, Xu-xu Wei, Hong-cai Shang. Evaluating the methodology of studies conducted during the global COVID-19 pandemic: A systematic review of randomized controlled trials. Journal of Integrative Medicine, 2021, 19(4): 317-326.
[9] Qiu-yu Tong, Ran Liu, Kun Zhang, Yuan Gao, Guang-wei Cui, Wei-dong Shen. Can acupuncture therapy reduce preoperative anxiety? A systematic review and meta-analysis. Journal of Integrative Medicine, 2021, 19(1): 20-28.
[10] Liang Dai, Ka Kei Chan, Jian-chun Mao, Yu Tian, Jun-hua Gu, Jun Zhou, Linda L.D. Zhong. Modified Zhibai Dihuang pill, a traditional Chinese medicine formula, on steroid withdrawal in systemic lupus erythematosus: A systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(6): 478-491.
[11] Arthur Yin Fan, Sherman Gu, Sarah Faggert Alemi, Research Group for Evidence-based Chinese Medicine. Chinese herbal medicine for COVID-19: Current evidence with systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(5): 385-394.
[12] Xian-jun Xiao, Lei-xiao Zhang, Yun-zhou Shi, Jun-peng Yao, Wei Cao, Ying Liu, Zi-hao Zou, Si-yuan Zhou, Ming-ling Chen, Chun-xiao Li, Qian-hua Zheng, Ying Li. Cupping therapy for patients with chronic urticaria: A systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(4): 303-312.
[13] Esmaeil Yousefi Rad, Behzad Nazarian, Somayeh Saboori, Ebrahim Falahi, Azita Hekmatdoost. Effects of L-arginine supplementation on glycemic profile: Evidence from a systematic review and meta-analysis of clinical trials. Journal of Integrative Medicine, 2020, 18(4): 284-291.
[14] Dong-dong Yu, Liang-zhen You, Wan-qiu Huang, Hui Cao, Fan-jing Wang, Xiu-qin Tang, Zhao-hui Fang, Guo-ming Shen, Yu-xiang Guan. Effects of traditional Chinese exercises on blood glucose and hemoglobin A1c levels in patients with prediabetes: A systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(4): 292-302.
[15] Hepatology Committee of Chinese Association of Integrative Medicine, China. Guidelines for diagnosis and treatment of hepatic fibrosis with integrated traditional Chinese and Western medicine (2019 edition). Journal of Integrative Medicine, 2020, 18(3): 203-213.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Jin-rong Fu. Establishment of multivariate diagnosis and treatment system of modern gynecology of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 22-24
[2] Hao Li, Ming-jiang Yao, Wen-ming Zhao, Jie Guan, Lin-lin Cai, Ling Cui. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment. Journal of Chinese Integrative Medicine, 2008, 6(1): 25-31
[3] Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[4] SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5] Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[6] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7] Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[8] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[9] Gui Yu, Jie Wang. Thinking on building the network cardiovasology of Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1206-1210
[10] Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239
Journal of Integrative Medicine, ISSN: 2095-4964 CN 31-2083/R
Copyright © Journal of Integrative Medicine
Powered by Beijing Magtech Co. Ltd
沪公网安备31010602003416号      沪ICP备18017633号-3