Ethnobotany and phytopharmacology of Pinus roxburghii Sargent: A plant review

doi:10.3736/jintegrmed2013053

Abstract

Traditional medicine is a blend of information gathered over generations from various communities and cultures. Pinus roxburghii Sargent (Pinaceae) commonly known as “chir pine” is widely used in traditional and folkloric systems of medicine. The all parts of the plant are believed to possess medicinal qualities in Ayurvedic and Unani systems of medicine. In these traditional systems of medicine, the plant is used to heal many diseases, including afflictions of the eyes, ears, throat, blood, and skin. The plant parts are rich in various bioactive compounds such as α-pinene, abietic acid, quercetin and xanthone. Resin acids and flavanoid form a major portion of these bioactive compounds. This review presents examples of traditional medicinal uses for P. roxburghii, and subsequently explores the current understanding of the chemical, pharmacological, and biochemical properties of the extracts and the main active constituents found in each tissue of the plant. Clinical trial information is also included where available. Careful evaluation of these data may be helpful for scientists and researchers to discover and evaluate the specific chemical entities responsible for the traditional medicinal uses of P. roxburghii.

Key words: Pinus roxburghii Sargeant, Phytochemistry, Pharmacology, Ethnopharmacology, Review

Pawan Kaushik, Dhirender Kaushik, Sukhbir Lal Khokra. Ethnobotany and phytopharmacology of Pinus roxburghii Sargent: A plant review. Journal of Chinese Integrative Medicine, 2013, 11(6): 371-376.

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[1]	Shah R . Description of Pinus roxburghii Sarg[J]. Nat Med Plants Uttaranchal, 2006,1:18-19
[2]	The wealth of India: A dictionary of Indian raw materials and industrial products.Vol 1[M]. New Delhi: Council of Scientific and Industrial Research, 1985, 69-83
[3]	Price RA, Liston A, Strauss SH. Phylogeny and systematics of Pinus. In: Richardson DM.Ecology and biogeography of Pinus[M]. Cambridge: Cambridge University Press, 1998, 49-68
[4]	Wu ZY, Raven PH, Garden MB. Flora of China. Vol 4. Beijing: Science Press & St Louis: Missouri Botanical Garden Press. 1999.
[5]	Arya S, Kalia RK, Arya ID . Induction of somatic embryogenesis in Pinus roxburghii Sarg[J]. Plant Cell Reports, 2000,19(8):775-780 doi: 10.1007/s002990000197
[6]	Tiwari DN . A monograph on chir pine (Pinus roxburghii Sarg). Dehra Dun: Indian Council of Forestry Reaseach and Education. 1994.
[7]	Khare CP . Indian medicinal plants: an illustrated dictionary[M]. Berlin/Heidelberg: Springer Science+Business Media, LLC, 2007, 496-497
[8]	Siddiqui MF, Ahmed M, Wahab M, Khan N, Khan MU, Nazim K, Hussain SS . Phytosociology of Pinus roxburghii Sargent(Chir pine) in lesser Himalayan and Hindukush range of Pakistan[J]. Pak J Bot, 2009,41(5):2357-2359
[9]	Puri A, Srivastava AK, Singhal B, Mishra SK, Srivastava S, Lakshmi V . Antidyslipidemic and antioxidant activity of Pinus roxburghii needles[J]. Med Chem Res, 2011,20:1589-1593 doi: 10.1007/s00044-010-9424-0
[10]	Abbasi AM, Khan MA, Ahmad M, Zafar M, Jahan S, Sultana S . Ethnopharmacological application of medicinal plants to cure skin diseases and in folk cosmetics among the tribal communities of North-West Frontier Province. Pakistan[J]. J Ethnopharmacol, 2010,128(2):322-335 doi: 10.1016/j.jep.2010.01.052
[11]	Smaleh M, Sharma OP, Dobhal NP. Chemical composition of turpentine oil from oleoresin (Pinus roxburghii Sargent) tapped by chemical stimulants. Indian Perfumer. 1976; XX(1B):15-19.
[12]	Kunwar RM, Uprety Y, Burlakoti C, Chowdhary CL, Bussmann RW . Indigeneous use and ethanopharmacology of medicinal plants in far-west Nepal[J]. Ethnobot Res Applic, 2009,7:5-28 doi: 10.17348/era.7.0.5-28
[13]	Gangwar AK, Ramakrishnan PS . Ethnobiological notes on some tribes of Arunachal Pradesh, Northeastern India[J]. Econ Bot, 1990,44(1):94-105 doi: 10.1007/BF02861071
[14]	Singh H, Saklani A, Lal B . Ethnobotanical observations on some gymnosperms of Garhwal Himalaya, Uttar Pradesh, India[J]. Econ Bot, 1990,44(3):349-354 doi: 10.1007/BF03183917
[15]	Bhattarai NK . Medical ethnobotany in the Karnali zone. Nepal[J]. Econ Bot, 1992,46(3):257-261 doi: 10.1007/BF02866624
[16]	Joshi K, Joshi R, Joshi AR . Indigenous knowledge and uses of medicinal plants in Macchegaun, Nepal[J]. Indian J Tradi Knowl, 2011,10(2):281-286
[17]	Manandhar NP. Plant and people of Nepal. Portland: Timber Press Inc. 2002.
[18]	Murad W, Ahmad A, Gilani SA, Khan MA . Indigenous knowledge and folk use of medicinal plants by the tribal communities of Hazar Nao Forest, Malakand District, North Pakistan[J]. J Med Plant Res, 2011,5(7):1072-1086
[19]	Ajmal SA, Mohammad S, Zahid K, Bakht Z, Habib A, Alam MZ . Ethnomedicinal and phytoeconomic elaboration of Lilownai Valley, District Shangla, Pakistan[J]. Int Res J Pharma, 2012,3(4):164-169
[20]	Hussain M . Medicinal plants of mansehra[M]. Peshawar: Botany Department, University of Peshawar, 1987,174
[21]	Krithikar KR, Basu BD . Indian medicinal plants.2nd ed[M]. Dehardun: International Book Distributors, 1999, 2385-2388
[22]	Arshad M, Ahmad M .Medico-botanical investigation of medicinally important plants from Galliyat areas, NWFP(Pakistan) [J].Ethnobot Leaflets, 2005, 2005(1):Article 23
[23]	Uniyal SK, Singh KN, Jamwal P, Lal B . Traditional use of medicinal plants among the tribal communities of Chhota Bhangal, Western Himalaya[J]. J Ethnobiol Ethnomed, 2006,2:14 doi: 10.1186/1746-4269-2-14
[24]	Bajracharya MB. Ayurvedic medicinal plants and general treatments[M]. Kathmandu: Jore Ganesh Press Pvt Ltd, 1979,230
[25]	Dash VB, Gupta KK . Materia medica of Ayurveda. New Delhi: Health Harmony, B. Jain Publishers, Ltd. 1991.
[26]	Jain SK . Medicinal plants.6th ed[M]. New Delhi: National Book Trust, 1994,216
[27]	Marles RJ, Farnsworth NR . Antidiabetic plants and their active constituents[J]. Phytomedicine, 1995,2(2):137-189 doi: 10.1016/S0944-7113(11)80059-0
[28]	Chaturvedi S, Dass S . Traditional medicinal and economic uses of gymnosperms[J]. Bull Env Pharmacol Life Sci, 2011,1(1):70-72
[29]	Kala CP . Indigenous uses and structure of chir pine forest in Uttaranchal Himalaya, India[J]. Int J Sust Dev World Ecol, 2004,11(2):205-210 doi: 10.1080/13504500409469824
[30]	Chatterjee A, Dhara KP, Rej RN, Ghosh PC . Hexacosylferulate, a phenolic constituent of Pinus roxburghii[J]. Phytochemistry, 1977,16(3):397-398 doi: 10.1016/0031-9422(77)80076-9
[31]	Rawat U, Srivastava B, Semwal S, Sati OP . Xanthones from Pinus roxburghii[J]. J Indian Chem Soc, 2006,83(4):391-392
[32]	Beri RM . Chemical constituents of the bark of Pinus roxburghii Sargent[J]. Indian J Chem, 1970,8(5):469-470
[33]	Willf?r S, Ali M, Karonen M, Reunanen M, Arfan M, Harlamow R . Extractives in bark of different conifer species growing in Pakistan[J]. Holzforschung, 2009,63(5):551-558
[34]	Coppen JJ, Robinson JM, Kaushal AN . Composition of xylem resin from Pinus wallichiana and P. roxburghii[J]. Phytochemistry, 1988,27(9):2873-2875 doi: 10.1016/0031-9422(88)80679-4
[35]	Naeem I, Taskeen A, Mubeen H, Maimoona A . Characterization of flavonols present in barks and needles of Pinus wallichiana and Pinus roxburghii[J]. Asian J Chem, 2010,22(1):41-44
[36]	Ahmad M, Nazli S, Anwar MM . Studies on tannins from barks of Pinus roxburghii[J]. J Chem Soc Pak, 1989,11(3):213-217
[37]	Satyal P, Paudel P, Raut J, Deo A, Dosoky NS, Setzer WN . Volatile constituents of Pinus roxburghii from Nepal[J]. Pubmed Res, 2013,5(1):43-48
[38]	Zafar I, Fatima A, Khan SJ, Rehman Z, Mehmud S . GC-MS studies of needles essential oil of Pinus roxburghaii and their antimicrobial activity from Pakistan[J]. Electr J Environ Agric Food Chem, 2010,9(3):468-473
[39]	Hassan A, Amjid I . Gas chromatography-mass spectrometric studies of essential oil of Pinus roxburghii stems and their antibacterial and antifungal activities[J]. J Med Plants Res, 2009,3(9):670-673
[40]	Swales M, Dev I . Indian wood turpentine oil: scope, production and chemical composition. Indian Perfumer. 1979; XXIII(2):79-83.
[41]	Mishra AN, Soman R, Dev S . Monoterpenoids-VI: On the optical purity of(+)-car-3-ene from Pinus roxburghi and the source of racemization of(-)-menthol derived therefrom[J]. Tetrahedron, 1988,44:6941-6946 doi: 10.1016/S0040-4020(01)86224-4
[42]	Ahmad M, Nazli S, Mohammad B . Separation and analysis of sugars from Pinus roxburghii bark[J]. Pak J Sci Ind Res, 1990,33(12):558-560
[43]	Maimoona A, Naeem I, Shujaat S, Saddiqe Z, Mughal T, Mehmood T . Comparison of radical scavenging capacity of different extracts of bark and needles of Pinus roxburghii and Pinus wallichiana[J]. Asian J Chem, 2011,23(2):819-822
[44]	Maimoona A, Naeem I, Saddiqe Z, Ali N, Ahmed G, Shah I . Analysis of total flavonoids and phenolics in different fractions of bark and needle extracts of Pinus roxburghii and Pinus wallichiana[J]. J Med Plant Res, 2011,5(13):2724-2728
[45]	Khan I, Singh V, Chaudhary AK . Hepatoprotective activity of Pinus roxburghii Sarg. wood oil against carbon tetrachloride and ethanol induced hepatotoxicity[J]. Bangladesh J Pharmacol, 2012,7(2):94-99
[46]	Bissa S, Bohra A, Bohra A . Antibacterial potential of three naked-seeded(Gymnosperm) plants[J]. Indian J Nat Prod Radiance, 2008,7(5):420-425
[47]	Parihar P, Parihar L, Bohra A . Antibacterial activity of extracts of Pinus roxburghii Sarg[J]. Bangladesh J Bot, 2006,35(1):85-86
[48]	Chaudhary KA, Ahmad S, Mazumder A . Study of antibacterial and antifungal activity of traditional Cedrus deodara and Pinus roxburghii Sarg[J]. TANG, 2012,2(4):e37
[49]	Melkania NP, Singh JS, Bisht KKS . Allelopathic potential of Artemisia vulgaris L. and Pinus roxburghii Sargent: A bioassay study[J]. Proc Indian Nat Sci Acad B, 1982,48(5):685-688
[50]	Kaushik D, Kumar A, Kaushik P, Rana AC . Analgesic and anti-inflammatory activity of Pinus roxburghii Sarg[J]. Adv Pharmacol Sci, 2012,2012:245431
[51]	Kaushik D, Kumar A, Kaushik P, Rana AC . Anticonvulsant activity of alcoholic extract of bark of Pinus roxburghii Sarg[J]. J Chin Integr Med, 2012,10(9):1056-1060
[52]	Kaushik DK . Phytochemical and pharmacological evaluation of Pinus roxburghii Sarg. Kurukshetra: Kurukshetra University. 2011.
[53]	Mahajan VK, Sharma NL . Occupational airborne contact dermatitis caused by Pinus roxburghii sawdust[J]. Contact Dermat, 2011,64(2):110-111 doi: 10.1111/cod.2011.64.issue-2
[54]	Chaudhary AK, Ahmad S , Mazumder A. Cognitive enhancement in aged mice after chronic administration of Cedrus deodara Loud. and Pinus roxburghii Sarg. with demonstrated antioxidant properties. J Nat Med. 2013 May 5. Epub ahead of print.
[55]	Azmat A, Ahmed KZ, Ahmed M, Tariq B . Antinociceptive effects of poly herbal oil extract(PHOE)[J]. Pak J Pharmacol, 2006,23(2):1-7
[56]	Rastogi S, Shukla A, Kolhapure SA . Evaluation of the clinical efficacy and safety of RG-01(Rumalaya gel) in the management of chronic sub-acute inflammatory joint disorder[J]. Med Update, 2004,12(1):31-37
[57]	Sharma A, Kolhapure SA . Evaluation of the efficacy and safety of Rumalaya gel in the management of acute and chronic inflammatory musculoskeletal disorders: an open, prospective, noncomparative, phase III clinical trial[J]. Med Update, 2005,12(10):39-45
[58]	Ahmad R, Rao RAK, Masood MM . Removal and recovery of Cr(VI) from synthetic and industrial wastewater using bark of Pinus roxburghii as an adsorbent[J]. Water Qual Res J Canada, 2005,40(4):462-468 doi: 10.2166/wqrj.2005.049

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