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Journal of Integrative Medicine ›› 2022, Vol. 20 ›› Issue (3): 193-203.doi: 10.1016/j.joim.2022.02.008

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Effects of turmeric (Curcuma longa) and its constituent (curcumin) on the metabolic syndrome: An updated review

Zeinab Vafaeipoura,b, Bibi Marjan Razavib,c, Hossein Hosseinzadehb,d   

  1. a. Student Research Committee, Mashhad University of Medical Sciences, Mashhad 9177948954, Iran
    b. Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 9177948954, Iran
    c. Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177948954, Iran
    d. Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177948954, Iran
  • Received:2020-12-06 Accepted:2022-01-13 Online:2022-05-09 Published:2022-03-09
  • Contact: Hossein Hosseinzadeh E-mail:hosseinzadehh@mums.ac.ir

Metabolic syndrome (MS) involves people with the following risk factors: obesity, hypertension, high glucose level and hyperlipidemia. It can increase the risk of heart disease, stroke and type 2 diabetes mellitus. The prevalence of MS in the world’s adult population is about 20%–25%. Today, there is much care to use medicinal plants. Turmeric (Curcuma longa) as well as curcumin which is derived from the rhizome of the plant, has been shown beneficial effects on different components of MS. Thus, the purpose of this manuscript was to introduce different in vitroin vivo and human studies regarding the effect of turmeric and its constituent on MS. Moreover, different mechanisms of action by which this plant overcomes MS have been introduced. Based on studies, turmeric and its bioactive component, curcumin, due to their anti-inflammatory and antioxidant properties, have antidiabetic effects through increasing insulin release, antihyperlipidemic effects by increasing fatty acid uptake, anti-obesity effects by decreasing lipogenesis, and antihypertensive effects by increasing nitric oxide. According to several in vivoin vitro and human studies, it can be concluded that turmeric or curcumin has important values as a complementary therapy in MS. However, more clinical trials should be done to confirm these effects. 

Key words: Turmeric, Curcuma longa, Curcumin, Metabolic syndrome, Diabetes, Hyperlipidemia

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