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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (5): 364-366.doi: 10.3736/jcim20040516

• Original Experimental Research • Previous Articles     Next Articles

Anti-lipid peroxidation effect of Rosa davurica Pall. fruit

Shu-ping Jiao, Biao Chen, Pei-ge Du   

  1. Department of Biochemistry, College of Medicine, Beihua University, Jilin, Jilin Province 132001,China
  • Received:2003-10-20 Online:2004-09-20 Published:2018-10-20

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Objective: To study the anti-lipid peroxidation action of Rosa davurica Pall. fruit.Methods: The contents of malondialdehyde (MDA) of the tissue homogenate of the liver, heart, kidney, brain and of the red blood cells induced by hydrogen peroxide in mice were measured. The contents of MDA and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of ischemic myocardium of mice were measured.Results: 0.2 g/L Rosa davurica Pall. fruit could decrease significantly the contents of MDA of the all tissue (P<0.05). Inhibition rate of 6.7 g/L Rosa davurica Pall. fruit on MDA of the red blood cells induced by hydrogen peroxide was 89.2%. Administration of this extraction successively for six days (ig, 2.0 g·kg -1·d -1) can significantly reduce the content of MDA (P<0.01) and augment the activities of SOD and GHS-Px (P<0.05) in the ischemic myocardium of mice. Conclusion: Rosa davurica Pall. fruit can significantly prevent the lipid peroxidation.

Key words: Rosa davurica Pall. fruit, lipid peroxides, superoxide dismutase, glutathione peroxidase

CLC Number: 

  • R285

Tab 1

Anti-lipid peroxidation effect of extract of Rosa davurica Pall. fruit on tissue homogenate of mice ($\bar{x}$±s )"

Group n Heart Liver Kidney Brain
MDA
(nmol/g)		 Inhibition
(%)		 MDA
(nmol/g)		 Inhibition
(%)		 MDA
(nmol/g)		 Inhibition
(%)		 MDA
(nmol/g)		 Inhibition
(%)
Control 5 571.3±88.1 826.3±113.1 447.2±91.3 845.2±103.3
Rosa davurica Pall.（0.2 g/L） 5 472.4±91.4* 17.3 567.4±93.4* 31.7 328.6±84.9* 24.4 563.4±89.6* 33.4
Rosa davurica Pall.（0.4 g/L） 5 137.2±83.6** 77.1 103.6±86.7** 87.5 128.3±87.9** 71.4 113.8±84.9** 86.6

Tab 2

Effect of extract of Rosa davurica Pall. fruit on MDA, SOD, GSH-Px of ischemic myocardium of mice ($\bar{x}$±s )"

Group n MDA (nmol/g) SOD (U/mg) GSH-Px (U/mg)
Control group 10 483.5±113.7 3.45±0.71 27.6±5.1
Model group 10 815.6±135.5** 2.24±0.38** 18.3±5.1**
Rosa davurica Pall. (4.0 g/kg) 10 503.7±121.9ΔΔ 3.64±0.77ΔΔ 28.9±6.2ΔΔ
Rosa davurica Pall. (2.0 g/kg) 10 596.2±122.3Δ 3.06±0.68Δ 23.3±4.7Δ
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