[an error occurred while processing this directive]

Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (9): 809-813.doi: 10.3736/jcim20090902

• Systematic Review • Previous Articles     Next Articles

Efficacy of Maxing Shigan Decoction combined with Western medicine for pneumonia in children: A systematic review and meta-analysis

Ling Lia, Fang-guo Lua, Qing-hu Heb   

  1. a Department of Microbiology, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China
    b College of Integrated Traditional Chinese and Western Medicine,Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China
  • Received:2009-06-18 Accepted:2009-07-27 Online:2009-09-20 Published:2009-09-15
  • Contact: Fang-guo Lu E-mail:lufangguo@tom.com

Objective

To systematically evaluate the clinical effects of Maxing Shigan Decoction (MXSGD), a compound traditional Chinese herbal medicine, combined with Western medicine on pneumonia in children.
Methods

In this study, the relative trials published from 1994 to 2008 were searched in Chongqing Weipu Database, Chinese Journal Full-text Database, Wanfang database, Chinese Biomedical Literature Database and other electronic database by using the method of Cochrane systematic review. At the same time the information from related journals, professional data and network were hand-searched. The methodological quality of the included trials was assessed by two evaluators, and homogeneous evaluation by meta-analysis was performed. Statistical analysis of clinical data was performed by using RevMan 4.2.7 software provided by the Cochrane Collaboration.
Results

A total of 146 reports were found, while only eight randomized controlled trials met the inclusion criteria. The methodology quality of the reports included in the study was evaluated by the Jadad scale, and the specific random method, allocation concealment, blinding and intention-to-treat analysis were not described in all of the eight trial reports. As MXSGD combined with Western medicine group (treatment group) was compared with Western medicine group (control group), the meta-analysis indicated that the odds ratio for the total effective rate was 4.06, and the 95% confidence interval was from 2.63 to 6.27. MXSGD combined with Western medicine was good at increasing the total effective rate as compared with Western medicine, and the difference was statistically significant (P<0.000 01).
Conclusion

MXSGD combined with Western medicine can improve clinical symptoms and increase the total effective rate of the patients with pneumonia in children. However, its clinical effects should be further identified by high quality, multicenter and randomized controlled trials with large-scale design.

Key words: Maxing Shigan Decoction, Infantile pneumonia, Randomized controlled trial, Systematic review, Meta-analysis

Table 1

Clinical characteristics of enrolled trials"

Study Intervention Cases (male/female) Age ($\bar{x}$±s, years)
Treatment
group
Control
group
Treatment
group
Control
group
Duration
(day)
Treatment
group
Control
group
1 Guo JP[3] MXSGD and control
intervention
Basic therapy and
symptomatic support
145(85/60) 80(45/35) 7-9 Did not report
mean age
Did not report mean age
2 Wei YJ et al[4] MXSGD and control
intervention
Basic therapy 64(42/22) 64(48/16) 7 Did not report
mean age
Did not report
mean age
3 Zhang XP[5] MXSGD and control
intervention
Basic therapy 100(74/26) 100(68/32) 20 Did not report
mean age
Did not report
mean age
4 Ye HN et al[6] MXSGD and control
intervention
Basic therapy 50(24/26) 50(28/22) 10 Did not report
mean age
Did not report
mean age
5 Wen JL[7] MXSGD and control
intervention
Basic therapy and
symptomatic support
40(21/19) 40(25/15) 10 Did not report
mean age
Did not report
mean age
6 He ZM[8] MXSGD and control
intervention
Basic therapy and
symptomatic support
82(42/40) 67(34/33) 7 2.26±1.04 2.32±1.29
7 Li J[9] MXSGD and control
intervention
Basic therapy and
symptomatic support
48(28/20) 28(16/12) 10 Did not report
mean age
Did not report
mean age
8 Hou L et al[10] MXSGD and control
intervention
Basic therapy 24(13/11) 22(12/10) 5 2.8±1.0 2.5±1.1

Table 2

Methodological quality of enrolled trials"

Study number Randomization Allocation concealment Blinding Blinding method ITT Jadad score
1 Yes Not mentioned No Not mentioned No 1
2 Yes Not mentioned No Not mentioned No 1
3 Yes Not mentioned No Not mentioned No 1
4 Yes Not mentioned No Not mentioned No 1
5 Yes Not mentioned No Not mentioned No 1
6 Yes Not mentioned Yes Not mentioned No 2
7 Yes Not mentioned No Not mentioned No 1
8 Yes Not mentioned No Not mentioned No 1

Figure 1

Meta analysis of MXSGD combined with Western medicine in treatment of pneumonia in children"

Figure 2

Funnel plot analysis"

[1] Jadad AR, Moore A, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ , McQuay HJ.Assessing the quality of reports of randomized clinical trials: is blinding necessary?[J]. Control Clin Trials, 1996,17(1):1-12
doi: 10.1016/0197-2456(95)00134-4
[2] Mulrow CD , Oxman AD. Cochrane collaboration handbook[M]. Oxford: The Cochrane Library, 1997
[3] Guo JP . Modified Maxing Shigan Decoction in treatment of infantile pneumonia[J]. Shi Yong Zhong Xi Yi Jie He Za Zhi, 1997,10(19):1903
郭建平 . 麻杏石甘汤加减治疗小儿肺炎[J]. 实用中西医结合杂志, 1997,10(19):1903
[4] Wei YJ, Zhao GF, Ren PR . Clinical observation of integrated traditional Chinese and Western medicine in treatment of 64 cases of infantile bronchopneumonia[J]. Gansu Zhong Yi, 2001,14(2):9
doi: 10.3969/j.issn.1004-6852.2001.02.007
魏永俭, 赵国福, 任培荣 . 中西医结合治疗小儿支气管肺炎64例临床观察[J]. 甘肃中医, 2001,14(2):9
doi: 10.3969/j.issn.1004-6852.2001.02.007
[5] Zhang XP . Integrated traditional Chinese and Western medicine in treatment of 100 cases of infantile pneumonia[J]. Shanghai Zhong Yi Yao Za Zhi, 2003,37(2):27-28
张小平 . 中西医结合治疗小儿肺炎100例[J]. 上海中医药杂志, 2003,37(2):27-28
[6] Ye HN, Liang SX, Hu DL . Evaluation of integrated traditional Chinese and Western medicine in treatment of infantile pneumonia[J]. Xian Dai Lin Chuang Yi Xue Sheng Wu Gong Cheng Xue Za Zhi, 2004,10(3):251-252
doi: 10.3760/cma.j.issn.1674-1927.2004.03.037
叶慧宁, 梁少娴, 胡大磊 . 中西医结合治疗小儿肺炎评价[J]. 现代临床医学生物工程学杂志, 2004,10(3):251-252
doi: 10.3760/cma.j.issn.1674-1927.2004.03.037
[7] Wen JL . Clinical study of modified Maxing Shigan Decoction in treatment of bronchopneumonia(phlegm-heat blocking lung)[M]. Changchun: Changchun University of Traditional Chinese Medicine, 2005
文吉莲 . 麻杏石甘汤加味治疗支气管肺炎(痰热闭肺型)的临床研究[M]. 长春: 长春中医药大学, 2005
[8] He ZM . Clinical effects of Maxing Shigan Decoction combined with Western medicine in treatment of 82 cases of infantile pneumonia[J]. Sichuan Zhong Yi, 2005,23(3):74-75
doi: 10.3969/j.issn.1000-3649.2005.03.047
何志明 . 麻杏石甘汤联合西药治疗小儿支气管肺炎82例[J]. 四川中医, 2005,23(3):74-75
doi: 10.3969/j.issn.1000-3649.2005.03.047
[9] Li J . Clinical observation of Jiawei Maxing Shigan Decoction in complementary treatment of 48 cases of infantile mycoplasma pneumonia[J]. Zhong Yi Er Ke Za Zhi, 2007,3(3):40-41
doi: 10.3969/j.issn.1673-4297.2007.03.017
李静 . 加味麻杏石甘汤佐治小儿支原体肺炎48例临床观察[J]. 中医儿科杂志, 2007,3(3):40-41
doi: 10.3969/j.issn.1673-4297.2007.03.017
[10] Hou L, Zhou B . Effect observation of integrated traditional Chinese and Western medicine in treatment of 100 cases of infantile bronchopneumonia[J]. Lin Chuang He Shi Yan Yi Xue Za Zhi, 2008,7(6):170
doi: 10.3969/j.issn.1671-4695.2008.06.120
侯利, 周博 . 中西医结合治疗小儿支气管肺炎的疗效观察[J]. 临床和实验医学杂志, 2008,7(6):170
doi: 10.3969/j.issn.1671-4695.2008.06.120
[1] Jing-lin Shi, Wan-hong Miao. Effects of acupuncture on lactoferrin content in tears and tear secretion in patients suffering from dry eyes: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(9): 1003-1008.
[2] Ming T. Tan , Jian-ping Liu , Lixing Lao. Adequate application of quantitative and qualitative statistic analytic methods in acupuncture clinical trials. Journal of Chinese Integrative Medicine, 2012, 10(8): 847-852.
[3] Lu Yu, Shui-miao Lin, Ru-qian Zhou, Wei-jun Tang, Pin-xian Huang, Ying Dong, Jian Wang, Zhi-hua Yu, Jiu-lin Chen, Li Wei, San-li Xing, Hui-juan Cao, Hong-bin Zhao. Chinese herbal medicine for patients with mild to moderate Alzheimer disease based on syndrome differentiation: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(7): 766-776.
[4] Peng Fu , Xue-qiang Huang, Ai-hong Yuan, Guang Yu, Xiao-bin Mei, Ruo-lan Cu. Effects of salvianolate combined with alprostadil and reduced glutathione on progression of chronic renal failure in patients with chronic kidney diseases: a long-term randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(6): 641-646.
[5] Hui Luo, Jian-ping Liu, Qing Li. Methodological issues and suggestions for improvement in randomized controlled trials of Chinese herbal medicine for recurrent miscarriage. Journal of Chinese Integrative Medicine, 2012, 10(6): 604-614.
[6] Shui-qiu Deng, Xue-nong Ouyang, Zong-yang Yu, Xi-hu Dai, Xi Chen, Fang-zheng Fang, Wen-wu Wang, Zhi-zhen Liu. Influence of Chinese herbal medicine Feitai Capsule on completion or delay of chemotherapy in patients with stage ⅢB/Ⅳ non-small-cell lung cancer: a Randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(6): 635-640.
[7] Ming-xing Zhao, Zhen-hua Dong, Zhong-hai Yu, Shi-yuan Xiao, Ya-ming Li . Effects of Ginkgo biloba extract in improving episodic memory of patients with mild cognitive impairment: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(6): 628-634.
[8] Ying-chun Miao , Jin-zhou Tian , Jing Shi , Min Mao. Effects of Chinese medicine for tonifying the kidney and resolving phlegm and blood stasis in treating patients with amnestic mild cognitive impairment: A randomized, double-blind and parallel-controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(4): 390-397.
[9] Xiao-hui Sun, Sheng Liu . External Chinese medical therapy for pain associated with hyperplastic disease of the breast: Study protocol of a randomized, double-blind, multicenter, controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(4): 384-389.
[10] Zhu Yan-feng, Luo Hai-ming, Deng Zhong-long, Fu De-yu, Yao Wang, Dai Jian. Effects of the Chinese patent medicine, Honghua Injection, on platelet glycoprotein Ⅱb/Ⅲa receptors in patients with acute coronary syndrome: a randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(3): 318-323.
[11] Li Min, Yang Ming-hui, Liu Yi. Effects of Chinese herbal medicine Bushen Huoxue Granule on quality of life of patients with Parkinson disease: a randomized, double-blinded and placebo-controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(3): 310-317.
[12] Paula de Sousa Fragoso Ana, de Sá Ferreira Arthur. Evaluation of the immediate effects of manual acupuncture on brachial bicep muscle function in healthy individuals and poststroke patients: a study protocol of a parallel-group randomized clinical trial. Journal of Chinese Integrative Medicine, 2012, 10(3): 303-309.
[13] Li-xin Ma, Yu-yi Wang, Xin-xue Li, Jian-ping Liu . Systematic review on methodology of randomized controlled trials of post-marketing Chinese patent drugs for treatment of type 2 diabetes. Journal of Chinese Integrative Medicine, 2012, 10(3): 279-292.
[14] Wang Yun-fei, Que Hua-fa, Xu Jie-nan, Tang Han-jun, Xiang Huan-yu, Liu Xiao-dong, Zhang Zhen, Xing Jie, Shen Liang, Shan Wei, Liu An-min, Qiu Lian-yin, Deng Da-yi, Gao Dan. Assessment of external methods of traditional Chinese medicine in patients with chronic ulcer of the lower extremities: study protocol of a multicenter, randomized, parallel-group, prospective trial. Journal of Chinese Integrative Medicine, 2012, 10(2): 166-175.
[15] Liu Jian, Gao Ying, Kan Bao-hong, Zhou Li. Systematic review and meta-analysis of randomized controlled trials of Chinese herbal medicine in treatment of multiple sclerosis. Journal of Chinese Integrative Medicine, 2012, 10(2): 141-153.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228
[an error occurred while processing this directive]