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Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (9): 809-813.doi: 10.3736/jcim20090902

• Systematic Review • Previous Articles     Next Articles

Efficacy of Maxing Shigan Decoction combined with Western medicine for pneumonia in children: A systematic review and meta-analysis

Ling Lia, Fang-guo Lua, Qing-hu Heb   

  1. a Department of Microbiology, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China
    b College of Integrated Traditional Chinese and Western Medicine,Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China
  • Received:2009-06-18 Accepted:2009-07-27 Online:2009-09-20 Published:2009-09-15
  • Contact: Fang-guo Lu E-mail:lufangguo@tom.com

Objective

To systematically evaluate the clinical effects of Maxing Shigan Decoction (MXSGD), a compound traditional Chinese herbal medicine, combined with Western medicine on pneumonia in children.
Methods

In this study, the relative trials published from 1994 to 2008 were searched in Chongqing Weipu Database, Chinese Journal Full-text Database, Wanfang database, Chinese Biomedical Literature Database and other electronic database by using the method of Cochrane systematic review. At the same time the information from related journals, professional data and network were hand-searched. The methodological quality of the included trials was assessed by two evaluators, and homogeneous evaluation by meta-analysis was performed. Statistical analysis of clinical data was performed by using RevMan 4.2.7 software provided by the Cochrane Collaboration.
Results

A total of 146 reports were found, while only eight randomized controlled trials met the inclusion criteria. The methodology quality of the reports included in the study was evaluated by the Jadad scale, and the specific random method, allocation concealment, blinding and intention-to-treat analysis were not described in all of the eight trial reports. As MXSGD combined with Western medicine group (treatment group) was compared with Western medicine group (control group), the meta-analysis indicated that the odds ratio for the total effective rate was 4.06, and the 95% confidence interval was from 2.63 to 6.27. MXSGD combined with Western medicine was good at increasing the total effective rate as compared with Western medicine, and the difference was statistically significant (P<0.000 01).
Conclusion

MXSGD combined with Western medicine can improve clinical symptoms and increase the total effective rate of the patients with pneumonia in children. However, its clinical effects should be further identified by high quality, multicenter and randomized controlled trials with large-scale design.

Key words: Maxing Shigan Decoction, Infantile pneumonia, Randomized controlled trial, Systematic review, Meta-analysis

Table 1

Clinical characteristics of enrolled trials"

Study Intervention Cases (male/female) Age ($\bar{x}$±s, years)
Treatment
group
Control
group
Treatment
group
Control
group
Duration
(day)
Treatment
group
Control
group
1 Guo JP[3] MXSGD and control
intervention
Basic therapy and
symptomatic support
145(85/60) 80(45/35) 7-9 Did not report
mean age
Did not report mean age
2 Wei YJ et al[4] MXSGD and control
intervention
Basic therapy 64(42/22) 64(48/16) 7 Did not report
mean age
Did not report
mean age
3 Zhang XP[5] MXSGD and control
intervention
Basic therapy 100(74/26) 100(68/32) 20 Did not report
mean age
Did not report
mean age
4 Ye HN et al[6] MXSGD and control
intervention
Basic therapy 50(24/26) 50(28/22) 10 Did not report
mean age
Did not report
mean age
5 Wen JL[7] MXSGD and control
intervention
Basic therapy and
symptomatic support
40(21/19) 40(25/15) 10 Did not report
mean age
Did not report
mean age
6 He ZM[8] MXSGD and control
intervention
Basic therapy and
symptomatic support
82(42/40) 67(34/33) 7 2.26±1.04 2.32±1.29
7 Li J[9] MXSGD and control
intervention
Basic therapy and
symptomatic support
48(28/20) 28(16/12) 10 Did not report
mean age
Did not report
mean age
8 Hou L et al[10] MXSGD and control
intervention
Basic therapy 24(13/11) 22(12/10) 5 2.8±1.0 2.5±1.1

Table 2

Methodological quality of enrolled trials"

Study number Randomization Allocation concealment Blinding Blinding method ITT Jadad score
1 Yes Not mentioned No Not mentioned No 1
2 Yes Not mentioned No Not mentioned No 1
3 Yes Not mentioned No Not mentioned No 1
4 Yes Not mentioned No Not mentioned No 1
5 Yes Not mentioned No Not mentioned No 1
6 Yes Not mentioned Yes Not mentioned No 2
7 Yes Not mentioned No Not mentioned No 1
8 Yes Not mentioned No Not mentioned No 1

Figure 1

Meta analysis of MXSGD combined with Western medicine in treatment of pneumonia in children"

Figure 2

Funnel plot analysis"

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