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Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (7): 636-640.doi: 10.3736/jcim20100706

• Original Clinical Research • Previous Articles     Next Articles

Effects of moxibustion at head-points on levels of somatostatin and arginine vasopressin from cerebrospinal fluid in patients with vascular dementia: A randomized controlled trial

 Pin Wanga, Jun Yangb, Gang Liub, Hao Chenb, Fan Yanga   

  1. a School of Acupuncture and Osteology, Anhui University of Traditional Chinese Medicine, Hefei 230038,Anhui Province, China
    b Acupuncture Hospital, Anhui University of Traditional Chinese Medicine, Hefei 230061, Anhui Province, China
  • Received:2009-12-31 Online:2010-07-20 Published:2010-07-15
  • Contact: Pin Wang E-mail:wangpin1890@163.com

Background

There are obvious changes in neuropeptides from plasma and cerebrospinal fluid in patients with vascular dementia (VaD), and regulating the levels of neuropeptides is a key for prevention and treatment of VaD.
Objective

To observe the clinical efficacy of moxibustion at head-points in treatment of vascular dementia (VaD), and assess its effects on memory-related neuropeptides.
Design, setting, participants and interventions

A total of 65 VaD patients from Acupuncture Hospital, Anhui University of Traditional Chinese Medicine, were randomly divided into moxibustion group (33 cases) and Western medicine group (32 cases). Patients in the moxibustion group were treated with indirect moxibustion with common monkshood cake for 20 min. Patients in the Western medicine group were orally administered piracetam tablets, 0.8 g for three times a day. One treatment course was 4 weeks, and they were treated for 4 treatment courses.
ain outcome measures

 The scores of Hasegawa’s Dementia Scale (HDS), Mini-Mental State Examination (MMSE), and Activity of Daily Living Scale (ADL), as well as the levels of learning and memory-related neuropeptides from cerebrospinal fluid such as somatostatin (SS) and arginine vasopressin (AVP) were measured before and after treatment in the two groups.
Results

Total response rate was significantly higher in the moxibustion group than in the Western medicine group (P<0.01). There were significant differences in scores of HDS, MMSE and ADL between before and after treatment in the two groups(P<0.05 or P<0.01). After treatment, the scores of HDS, MMSE and ADL in the moxibustion group were more improved as compared with those in the Western medicine group (P<0.05 or P<0.01). The levels of SS and AVP after treatment were higher than those before treatment in the two groups(P<0.01). After treatment, the increased levels of SS and AVP were higher in the moxibustion group than in the Western medicine group (P<0.01).
Conclusion

Moxibustion is effective in improving the clinical symptom scores and regulating the levels of neuropeptides associated with learning and memory in VaD patients.

Key words: Vascular dementia, Acupuncture moxibustion, Somatostatin, Arginine vasopressin, Randomized controlled trial

Figure 1

Flow diagram of this randomized trial"

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[1] Lu YW, Li ZX, Rong BB . Neuropetides and vascular dementia[J]. Yi Xue Zong Shu, 2006,12(6):348-350
doi: 10.3969/j.issn.1006-2084.2006.06.013
卢燕婉, 李作孝, 荣本兵 . 神经肽和血管性痴呆[J]. 医学综述, 2006,12(6):348-350
doi: 10.3969/j.issn.1006-2084.2006.06.013
[2] Baldereschi M, Amato MP, Nencini P, Pracucci G, Lippi A, Amaducci L, Gauthier S, Beatty L, Quiroga P, Klassen G, Galea A, Muscat P, Osuntokun B, Ogunniyi A, Portera-Sanchez A, Bermejo F, Hendrie H, Burdine V, Brashear A, Farlow M, Maggi S, Katzman R . WHO-PRA Age-Associated Dementia Working Group, WHO Program for Research on Aging, Health of Elderly Program. Cross-national interrater agreement on the clinical diagnostic criteria for dementia[J]. Neurology, 1994,44(2):239-242
doi: 10.1212/WNL.44.2.239
[3] Li WH . Criteria for clinical neurological impairment score in patients with cerebral apoplexy(1995)[J]. Zhonghua Shen Jing Ke Za Zhi, 1996,29(6):381
李文慧 . 脑卒中患者临床神经功能缺损程度评分标准(1995)[J]. 中华神经科杂志, 1996,29(6):381
[4] Liang YD . Revised Hasegawa Dementia Scale for diagnosis of dementia[J]. Riben Yi Xue Jie Shao, 1992,13(9):420
梁亦邓 . 用于痴呆诊断的修订长谷川量表[J]. 日本医学介绍, 1992,13(9):420
[5] State Bureau of Technical Supervision. National standard of People’s Republic of China: location of points[M]. Beijing: Standards Press of China,1990:
国家技术监督局. 中华人民共和国国家标准·经穴部位[M]. 北京: 中国标准出版社, 1990
[6] Gao SR, Yuan JM. Diagnostics and treatment of dementia[M]. Beijing: Beijing Science and Technology Press, 1998: 79
高素荣, 袁锦楣 . 痴呆诊疗学[M]. 北京: 北京科学技术出版社, 1998: 79
[7] Devanand DP, Folz M, Gorlyn M, Moeller JR, Stern Y . Questionable dementia: clinical course and predictors of outcome[J]. Am Geriatr Soc, 1997,45(3):321-328
doi: 10.1111/j.1532-5415.1997.tb00947.x pmid: 9063278
[8] Ministry of Health of the People’s Republic of China. Guidelines for clinical research on Chinese new herbal medicines[M]. Beijing: China Medical Science and Technology Press, 2000
中华人民共和国卫生部. 中药新药临床研究指导原则[M]. 北京: 中国医药科技出版社, 2000
[9] Yin XL, Li H, Jiao XM . Acupuncture treatment of vascular dementia research[J]. Shi Yong Zhong Yi Nei Ke Za Zhi, 2009,23(5):5-6
doi: 10.3969/j.issn.1671-7813.2009.05.02
殷晓莉, 李浩, 焦晓民 . 针灸治疗血管性痴呆研究述要[J]. 实用中医内科杂志, 2009,23(5):5-6
doi: 10.3969/j.issn.1671-7813.2009.05.02
[10] Wang JZ, Li Q, Gao C, Gao D, Zhang LL, Zhou HJ, Yao GE . Study on activity changes of angiotensinⅡ and arginine vasopresin in cerebrospinal fluid and its correlation with P300 peak latency in 50 patients with vascular dementia[J]. Zhongguo Lin Chuang Kang Fu, 2003,7(10):1500-1505
doi: 10.3321/j.issn:1673-8225.2003.10.009
王景周, 李强, 高唱, 高东, 张莉莉, 周红杰, 姚国恩 . 血管性痴呆50例脑脊液血管紧张素Ⅱ、精氨酸血管加压素变化与P300潜伏期的相关性[J]. 中国临床康复, 2003,7(10):1500-1505
doi: 10.3321/j.issn:1673-8225.2003.10.009
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