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Journal of Integrative Medicine ›› 2023, Vol. 21 ›› Issue (3): 236-244.doi: 10.1016/j.joim.2023.03.004

• Review • Previous Articles     Next Articles

Neuroprotective potential of cannabidiol: Molecular mechanisms and clinical implications

Srushti M. Tambea, Suraj Malib, Purnima D. Amina, Mozaniel Oliveirac   

  1. a. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga East, Mumbai 400019, India
    b. Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Ranchi 835215, India
    c. Adolpho Ducke Laboratory, Emilio Goeldi Museum, Para 66077-830, Brazil
  • Received:2022-09-12 Accepted:2023-03-10 Online:2023-05-15 Published:2023-05-15
  • Contact: Mozaniel Oliveira

Cannabidiol (CBD), a nonpsychotropic phytocannabinoid that was once largely disregarded, is currently the subject of significant medicinal study. CBD is found in Cannabis sativa, and has a myriad of neuropharmacological impacts on the central nervous system, including the capacity to reduce neuroinflammation, protein misfolding and oxidative stress. On the other hand, it is well established that CBD generates its biological effects without exerting a large amount of intrinsic activity upon cannabinoid receptors. Because of this, CBD does not produce undesirable psychotropic effects that are typical of marijuana derivatives. Nonetheless, CBD displays the exceptional potential to become a supplementary medicine in various neurological diseases. Currently, many clinical trials are being conducted to investigate this possibility. This review focuses on the therapeutic effects of CBD in managing neurological disorders like Alzheimer’s disease, Parkinson’s disease and epilepsy. Overall, this review aims to build a stronger understanding of CBD and provide guidance for future fundamental scientific and clinical investigations, opening a new therapeutic window for neuroprotection.

Key words: Cannabis sativa, Cannabidiol, Natural products, Bioactive compounds, Anti-neurodegenerative diseases

[1] Marco Cascella, Maria Rosaria Muzio. Potential application of the Kampo medicine goshajinkigan for prevention of chemotherapy-induced peripheral neuropathy. Journal of Integrative Medicine, 2017, 15(2): 77-87.
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