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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (4): 281-284.doi: 10.3736/jcim20040415

• Original Experimental Research • Previous Articles     Next Articles

Effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental precancerous lesion and its mechanism

Zuo-liang Chen1, Yu-qin Guan1, Xi Chen2, Xiao-ling Chen1, Jin-chun Chen3   

  1. 1. Xiamen Hospital of Stomatalogy, Xiamen, Fujian Province 361001, China
    2. School of Stomatalogy, Wuhan University, Wuhan, Hubei Province 430079, China
    3. Department of Internal Medicine, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, Fujian Province 361001, China
  • Received:2003-08-18 Online:2004-07-20 Published:2018-10-20

Objective: To study the effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental oral precancerous lesion and its mechanism.Methods: We treated the experimental oral precancerous lesion in hamster's cheek pouch using 1023 Recipe (consisting of Radix Astragali, Gynostemma Pentaphyllum, Rhizoma Chuanxiong and selenium-rich green tea) for 6 weeks, and observed its effect in blocking cancer transformation, detected 2 kinds of agglutinin receptors (receptors of wheat germ agglutinin and Ricinus communis agglutinin) in the mucosa of the hamster's cheek pouch.Results: The rate of cancer transformation in 1023 Recipe treated group was lower than that in the control group without treatment (P<0.05). Agglutinin receptors in the two groups were different significantly.Conclusion: 1023 Recipe is effective in treating hyperplasia, and can prevent its cancer transformation. The mechanism may be that 1023 Recipe can induce precancerous lesions to differentiate into normal tissues.

Key words: Chinese herbal medicine 1023 Recipe, precancerous lesion, blocking of cancer transformations, agglutinin receptors

CLC Number: 

  • R273.98

Tab 1

Tumor forming and atypical hyperplasia in 2 groups before experiment"

Group n Tumor forming case Tumor number Diameter of tumor Atypical hyperplasia
<1 cm >1 cm Light Moderate Severe
1023 Recipe treated 10 2 3 2 1 6 3 1
Control 10 2 4 3 1 7 2 1

Tab 2

Pathological histology test in 2 groups at different experimental time"

Group n Atypical hyperplasia Tumor forming case Tumor forming rate(%)
Light Moderate Severe
1023 Recipe treated
2nd week 10 2 6 2
4th week 10 2 2 2 4 40.0*
6th week 20 1 2 3 14 70.0*
Control
2nd week 10 1 5 3 1 10.0
4th week 10 3 7 70.0
6th week 20 20 100.0

Tab 3

Tumor number and size in 2 groups at the 6th week"

Group n Tumor number Average tumor number Tumor size
<1 cm >1 cm
1023 Recipe treated 20 30 1.5* 18 12
Control 20 58 2.9 15 43

Tab 4

Six kinds of agglutinin receptors in mucosa of normal hamster’s cheek pouch"

Tissue WGA RCA1 DBA UEA1 PNA BSA
Stratum corneum +++ + + + - +
Stratum granulosum ++ +/– +/–
Stratum spinosum ++
Stratum basale +
Basilar membrane

Tab 5

Staining of WGA receptor in different kinds of tissues"

Tissue Normal Hyperkeratosis Hyperplasia
Light Moderate Severe
Stratum corneum +++ +++ + ++ +
Stratum granulosum ++ +++ ++ ++ +
Stratum spinosum ++ ++ ++ ++ ++
Stratum basale + + + +

Tab 6

Staining of WGA receptor in different kinds of tissues in 1023 Recipe treated group"

Tissue Hyperkeratosis Hyperplasia
Light Moderate Severe
Stratum corneum +++ ++ ++ +
Stratum granulosum +++ +++ +++ ++
Stratum spinosum ++ ++ ++ +++
Stratum basale + + + +/–
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