1023中药合剂对实验性癌前损害癌变的阻断作用及其机制

doi:10.3736/jcim20040415

Abstract

Objective: To study the effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental oral precancerous lesion and its mechanism.Methods: We treated the experimental oral precancerous lesion in hamster's cheek pouch using 1023 Recipe (consisting of Radix Astragali, Gynostemma Pentaphyllum, Rhizoma Chuanxiong and selenium-rich green tea) for 6 weeks, and observed its effect in blocking cancer transformation, detected 2 kinds of agglutinin receptors (receptors of wheat germ agglutinin and Ricinus communis agglutinin) in the mucosa of the hamster's cheek pouch.Results: The rate of cancer transformation in 1023 Recipe treated group was lower than that in the control group without treatment (P<0.05). Agglutinin receptors in the two groups were different significantly.Conclusion: 1023 Recipe is effective in treating hyperplasia, and can prevent its cancer transformation. The mechanism may be that 1023 Recipe can induce precancerous lesions to differentiate into normal tissues.

Key words: Chinese herbal medicine 1023 Recipe, precancerous lesion, blocking of cancer transformations, agglutinin receptors

CLC Number:

R273.98

Zuo-liang Chen, Yu-qin Guan, Xi Chen, Xiao-ling Chen, Jin-chun Chen. Effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental precancerous lesion and its mechanism. Journal of Chinese Integrative Medicine, 2004, 2(4): 281-284.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20040415

http://www.jcimjournal.com/EN/Y2004/V2/I4/281

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Group	n	Tumor forming case	Tumor number	Diameter of tumor		Atypical hyperplasia
Group	n	Tumor forming case	Tumor number	<1 cm	>1 cm	Light	Moderate	Severe
1023 Recipe treated	10	2	3	2	1	6	3	1
Control	10	2	4	3	1	7	2	1

Group	n	Atypical hyperplasia			Tumor forming case	Tumor forming rate（％）
Group	n	Light	Moderate	Severe	Tumor forming case	Tumor forming rate（％）
1023 Recipe treated
2nd week	10	2	6	2
4th week	10	2	2	2	4	40.0*
6th week	20	1	2	3	14	70.0*
Control
2nd week	10	1	5	3	1	10.0
4th week	10			3	7	70.0
6th week	20				20	100.0

Group	n	Tumor number	Average tumor number	Tumor size
Group	n	Tumor number	Average tumor number	<1 cm	>1 cm
1023 Recipe treated	20	30	1.5*	18	12
Control	20	58	2.9	15	43

Tissue	WGA	RCA1	DBA	UEA1	PNA	BSA
Stratum corneum	+++	+	+	+	-	+
Stratum granulosum	++	+/–	–	+/–	–	–
Stratum spinosum	++	–	–	–	–	–
Stratum basale	+	–	–	–	–	–
Basilar membrane	–	–	–	–	–	–

Tissue	Normal	Hyperkeratosis	Hyperplasia
Tissue	Normal	Hyperkeratosis	Light	Moderate	Severe
Stratum corneum	+++	+++	+	++	+
Stratum granulosum	++	+++	++	++	+
Stratum spinosum	++	++	++	++	++
Stratum basale	+	+	+	+	–

Effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental precancerous lesion and its mechanism

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