Journal of Chinese Integrative Medicine ›› 2011, Vol. 9 ›› Issue (7): 702-710.doi: 10.3736/jcim20110702
• Systematic Review • Previous Articles Next Articles
Chit Moy Ley1, Amalia Tsiami1, Qing Ni2, Nicola Robinson3()
[1] | World Health Organization. Cardiovascular diseases. ( 2011)[ 2011-02-03]. 2011) [2011-02-03]. |
[2] | World Health Organization. Cardiovascular diseases (CVDs). (2011-01)[ 2011-02-03]. Cardiovascular diseases (CVDs). (2011-01) [2011-02-03]. |
[3] | British Heart Foundation , 1999-2009: a decade of achievements. ( 2010)[ 2011-02-03]. 2010) [2011-02-03]. . |
[4] | American Heart Association. Diabetes and cardiovascular disease. (2010-09-08)[ 2011-02-03]. Diabetes and cardiovascular disease. (2010-09-08) [2011-02-03]. . |
[5] |
Jackson PPR, Aarabi M, Wallis E .Aspirin for primary prevention of coronary heart disease[J].Cochrane Database Syst Rev, 2004,(1):CD004586
doi: 10.1002/14651858.CD004586 |
[6] |
Lip GY, Felmeden DC .Antiplatelet agents and anticoagulants for hypertension[J].Cochrane Database Syst Rev, 2004,( 3):CD003186
doi: 10.1002/14651858.CD003186.pub3 pmid: 22161375 |
[7] | Perez MI, Musini VM, Wright JM .Effect of early treatment with anti-hypertensive drugs on short and long-term mortality in patients with an acute cardiovascular event[J].Cochrane Database Syst Rev, 2009,( 4):CD006743 |
[8] | Taylor F, Ward K, Moore TH, Burke M, Davey Smith G, Casas JP , Ebrahim S.Statins for the primary prevention of cardiovascular disease[J].Cochrane Database Syst Rev, 2011,( 1):CD004816 |
[9] |
King DE, Ellis TM, Everett CJ, Mainous AG3rd .Medication use for diabetes, hypertension, and hypercholesterolemia from 1988-1994 to 2001-2006[J]. South Med J, 2009,102(11):1127-1132
doi: 10.1097/SMJ.0b013e3181bc74c8 pmid: 19864974 |
[10] |
Heinicke RM, Gortner WA . Stem bromelain — a new protease preparation from pineapple plants[J]. Econ Bot, 1957,11(3):225-234
doi: 10.1007/BF02860437 |
[11] | Kelly GS . Bromelain: a literature review and discussion of its therapeutic applications[J]. Alt Med Rev, 1996,1(4):243-257 |
[12] |
Guimarães-Ferreira CA, Rodrigues EG, Mortara RA, Cabral H, Serrano FA, Ribeiro-dos-Santos R, Travassos LR . Antitumor effects in vitro and in vivo and mechanisms of protection against melanoma B16F10-Nex2 cells by fastuosain, a cysteine proteinase from Bromelia fastuosa[J]. Neoplasia, 2007,9(9):723-733
doi: 10.1593/neo.07427 |
[13] |
Heinicke RM, van der Wal L, Yokoyama M . Effect of bromelain(Ananase) on human platelet aggregation[J]. Experientia, 1972,28(7):844-845
doi: 10.1007/BF01923166 pmid: 4658882 |
[14] | Metzig C, Grabowska E, Eckert K, Rehse K, Maurer HR . Bromelain proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo[J]. In Vivo, 1999,13(1):7-12 |
[15] |
Felton GE . Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients[J]. Med Hypotheses, 1980,6(11):1123-1133
doi: 10.1016/0306-9877(80)90134-6 pmid: 6256612 |
[16] | Pirotta F, De Giuli-Morghen C .Bromelain — a deeper pharmacological study. NoteⅠ. Antiinflammatory and serum fibrinolytic activity after oral administration in the rat[J]. Drugs Exp Clin Res, 1978,4:1-20 |
[17] |
Brien S, Lewith G, Walker A, Hicks SM, Middleton D . Bromelain as a treatment for osteoarthritis: a review of clinical studies[J]. Evid Based Complement Alternat Med, 2004,1(3):251-257
doi: 10.1093/ecam/neh035 pmid: 538506 |
[18] |
Brien S, Lewith G, Walker AF, Middleton R, Prescott P, Bundy R . Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study[J]. QJM, 2006,99(12):841-850
doi: 10.1093/qjmed/hcl118 |
[19] |
Rosenberg L, Lapid O, Bogdanov-Berezovsky A, Glesinger R, Krieger Y, Silberstein E, Sagi A, Judkins K, Singer AJ . Safety and efficacy of a proteolytic enzyme for enzymatic burn debridement: a preliminary report[J]. Burns, 2004,30(8):843-850
doi: 10.1016/j.burns.2004.04.010 |
[20] |
Neumayer C, Fügl A, Nanobashvili J, Blumer R, Punz A, Gruber H, Polterauer P, Huk I . Combined enzymatic and antioxidative treatment reduces ischemia-reperfusion injury in rabbit skeletal muscle[J]. J Surg Res, 2006,133(2):150-158
doi: 10.1016/j.jss.2005.12.005 |
[21] |
Bahde R, Palmes D, Minin E, Stratmann U, Diller R, Haier J, Spiegel HU . Bromelain ameliorates hepatic microcirculation after warm ischemia[J]. J Surg Res, 2007,139(1):88-96
doi: 10.1016/j.jss.2006.10.004 pmid: 17292418 |
[22] |
Gutfreund AE, Taussig SJ, Morris AK . Effect of oral bromelain on blood pressure and heart rate of hypertensive patients[J]. Hawaii Med J, 1978,37(5):143-146
pmid: 659096 |
[23] |
Taussig SJ . The mechanism of the physiological action of bromelain[J]. Med Hypotheses, 1980,6(1):99-104
doi: 10.1016/0306-9877(80)90038-9 pmid: 7382892 |
[24] |
Tochi BN, Wang Z, Xu SY, Zhang WB . Therapeutic application of pineapple protease(bromelain): a review[J]. Pakistan J Nutr, 2008,7(4):513-520
doi: 10.3923/pjn.2008.513.520 |
[25] | Joanna Briggs Institute . JBI comprehensive systematic review training program: Module 3 — The appraisal, extraction and pooling of quantitative Data. 2010. |
[26] |
Stevinson C, Lawlor DA . Searching multiple databases for systematic reviews: added value or diminishing returns?[J]. Complement Ther Med, 2004,12(4):228-232
doi: 10.1016/j.ctim.2004.09.003 pmid: 15649836 |
[27] |
Juhasz B, Thirunavukkarasu M, Pant R, Zhan L, Penumathsa SV, Secor ER Jr, Srivastava S, Raychaudhuri U, Menon VP, Otani H, Thrall RS, Maulik N . Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium[J]. Am J Physiol Heart Circ Physiol, 2008,294(3):H1365-H1370
doi: 10.1152/ajpheart.01005.2007 |
[28] |
Gaciong Z, Paczek L, Bojakowski K, Socha K, Wisniewski M, Heidland A . Beneficial effect of proteases on allograft arteriosclerosis in a rat aortic model[J]. Nephrol Dial Transplant, 1996,11(6):987-989
doi: 10.1093/oxfordjournals.ndt.a027521 pmid: 8671957 |
[29] | Nieper HA . Effect of bromelain on coronary heart disease and angina pectoris[J]. Acta Med Empirica, 1978,5:274-278 |
[30] |
Seligman B . Oral bromelains as adjuncts in the treatment of acute thrombophlebitis[J]. Angiology, 1969,20(1):22-26
doi: 10.1177/000331976902000103 pmid: 4885019 |
[31] |
Maurer HR . Bromelain: biochemistry, pharmacology and medical use[J]. Cell Mol Life Sci, 2001,58(9):1234-1245
doi: 10.1007/PL00000936 pmid: 11577981 |
[32] |
Malezieux E . Global network for pineapple research[J]. Acta Hortic, 2000,529:35-47
doi: 10.17660/ActaHortic.2000.529.2 |
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