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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (5): 323-325.doi: 10.3736/jcim20040502

Special Issue: Traditional Chinese Medicine

• Expert Forum • Previous Articles     Next Articles

Application of genomics and proteomics in study of traditional Chinese medicine

Jin-kun Wen(), Mei Han   

  1. Institute of Integrated Traditional Chinese and Western Medicine, HeBei Medical University, Shijiazhuang, HeBei Province 050017, China
  • Received:2004-08-02 Online:2004-09-20 Published:2018-10-20

The technique of genomics and proteomics is one of the fastest developments with the farest-reaching consequences in the high and new biotechnology in the world of today. It can be used to screen the target molecules of the action of traditional Chinese medicines, to identify the new effective components from traditional Chinese medicines,and to explore the mechanisms of the effects of traditional Chinese medicines. It meets the shortcomings of the conventional methodology being applied in the current studies of traditional Chinese medicine. Application of the theories and technique of genomics and proteomics in the study of traditional Chinese medicine would be of great significance for opening new research field of traditional Chinese medicine, for facilitating the integration of traditional Chinese medicine and modern biological science and technology, and for promoting the internationalization of traditional Chinese medicine.

Key words: genomice, proteomics, traditional Chinese medicine

CLC Number: 

  • R282
[1] Venter JC, Adams MD, Myers EW , et al. The sequence of the human genome[J]. Science, 2001,291(5507):1304-1351
doi: 10.1126/science.1058040
[2] Dove A . Proteomics: translating genomics into products[J]. Nat Biotechnol, 1999,17(3):233-236
doi: 10.1038/6972 pmid: 10096288
[3] Han M, Wen JK, Zheng B , et al. Acetylbritannilatone suppresses NO and PGE2 synjournal in RAW 264.7 macrophages through the inhibition of iNOS and COX-2 gene expression[J]. Life Sci, 2004,75(6):675-684
doi: 10.1016/j.lfs.2003.12.022
[4] 温进坤, 韩梅 . 益气活血法与血管平滑肌细胞基因表达调节[J]. 中西医结合学报, 2003,1(1):12-14
Wen JK, Han M . Supplementing Qi and activating blood circulation in gene regulation of vascular smooth muscle cells[J]. Zhong Xi Yi Jie He Xue Bao, 2003,1(1):12-14
[5] Du J, Jiang B, Coffey RJ , et al. Raf and RhoA cooperate to transform intestinal epithelial cells and induce growth resistance to transforming growth factor beta[J]. Mol Cancer Res, 2004,2(4):233-241
[6] Howat WJ, Holgate ST, Lackie PM . TGF-beta isoform release and activation during in vitro bronchial epithelial wound repair[J]. Am J Physiol Lung Cell Mol Physiol, 2002,282(1):L115-L123
doi: 10.1152/ajplung.2002.282.1.L115 pmid: 11741823
[7] Jones MB, Krutzsch H, Shu H , et al. Proteomic analysis and identification of new biomarkers and therapeutic targets for invasive ovarian cancer[J]. Proteomics, 2002,2(1):76-84
doi: 10.1002/(ISSN)1615-9861
[8] 王志平, 乔建军, 元英进 . 蛋白质组学在中药现代化研究中的应用[J]. 中草药, 2004,35(1):1-4
doi: 10.7501/j.issn.0253-2670.2004.1.002
[9] 路晓钦, 高月 . 中药复方现代化药理研究方法进展[J]. 中药新药与临床药理, 2002,13(1):59-61
doi: 10.3321/j.issn:1003-9783.2002.01.024
[10] 王升启 . 试论“中药基因组学”与“中药化学组学”[J]. 世界科学技术——中药现代化, 2000,2(1):28-31
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