SUBSCRIBE
Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2011, Vol. 9 ›› Issue (12): 1286-1291.doi: 10.3736/jcim20111202

Special Issue: Traditional Chinese Medicine

• Review • Previous Articles     Next Articles

Correlation between traditional Chinese medicine syndromes and omics: A literature review

 Shuo Zhang1,  Hong-cai Shang2()   

  1. 1. Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    2. Traditional Chinese Medicine Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • Received:2011-07-15 Accepted:2011-08-09 Online:2011-12-20 Published:2011-12-15

RichHTML

7

PDF (PC)

67

Cited

5

Like

As the post-genome era is approaching, omics has become a hot topic in the research field of life sciences and is also widely used in traditional Chinese medicine (TCM) research. For discussing the correlation between syndromes and omics, the authors explored the application of genomics, proteomics and metabonomics in the study of syndrome classification from the macroscopic view, after a systematic and normative study of the literature. The authors drew the conclusion that research into the correlation between syndromes and omics has great clinical significance in terms of the scientific application and quantification of TCM treatment based on syndrome differentiation.

Key words: disease, syndrome, genomics, proteomics, metabolomics, review

[1] Liu L . Omics technologies and their applications in Chinese medicine research and development. Shi Jie Ke Xue Ji Shu Zhong Yi Yao Xian Dai Hua. 2009 ; 11(2): 214-219. Chinese with abstract in English.
doi: 10.11842/wst.2009.2.[sequence]
刘良 . 充分利用组学技术研究及发展中医药.世界科学技术——中医药现代化. 2009; 11(2):214-219.
doi: 10.11842/wst.2009.2.[sequence]
[2] Jian WX, Yuan ZK . Progress in “omics” study of syndromes of traditional Chinese medicine. Shanghai Zhong Yi Yao Da Xue Xue Bao. 2008; 22(2) : 69-72. Chinese with abstract in English.
doi: 10.3969/j.issn.1008-861X.2008.02.022
简维雄, 袁肇凯 . 中医证候的组学研究进展.上海中医药大学学报. 2008; 22(2):69-72.
doi: 10.3969/j.issn.1008-861X.2008.02.022
[3] Jin GL . Discuss on syndrome genomics and syndrome proteomics. Zhongguo Yi Yao Xue Bao. 2003; 18(6): 332-335. Chinese with abstract in English.
doi: 10.3969/j.issn.1673-1727.2003.06.005
金光亮 . 证候基因组学和证候蛋白质组学浅论.中国医药学报. 2003; 18(6):332-335.
doi: 10.3969/j.issn.1673-1727.2003.06.005
[4] Pan L, Tan CE, Wang MQ, Zhang TE, Wang JG . Analysis of TCM syndrome patterns and different genes expressions of monozygotic twin with diabetes mellitus. Sichuan Zhong Yi. 2008; 26(10): 19-21. Chinese with abstract in English.
潘玲, 谭从娥, 王米渠, 张天娥, 王建国 . 一对糖尿病双生子病证结合调查及差异表达基因分析.四川中医. 2008; 26(10) : 19-21.
[5] Yang BL, Wang J, Jiang Y . Selection and clinical validation of relative gene bl3 of blood stasis syndrome in coronary heart disease. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi. 2007 ; 13(1) : 69-71. Chinese with abstract in English.
杨保林, 王阶, 姜燕 . 冠心病血瘀证相关基因bl3的筛查和临床验证.中国中医基础医学杂志. 2007; 13(1):69-71.
[6] Hang XP, Yuan ZK, Tan GB, Mao YL, Lu FG, Hu ZX, Tian S, Li J, Sun GX . Detective analysis on gene polymorphism of angiotensin converting enzyme in coronary heart disease patients with blood stasis syndrome. Zhong Yi Za Zhi. 2007; 48(1): 65-68. Chinese with abstract in English.
doi: 10.3321/j.issn:1001-1668.2007.01.036
黄献平, 袁肇凯, 谭光波, 毛以林, 卢芳国, 胡志希, 田松, 李杰, 孙贵香 . 冠心病血瘀证患者血管紧张素转换酶基因多态性的检测分析.中医杂志. 2007; 48(1):65-68.
doi: 10.3321/j.issn:1001-1668.2007.01.036
[7] Chen YH . Research on the expression of related genes and cell signaling proteins in gastric carcinoma patients with blood stasis syndrome. Guangzhou: Guangzhou University of Chinese Medicine. 2002 : 22-24. Chinese.
陈怡宏 . 胃癌血瘀证基因表达及细胞信号通道蛋白表达的研究.广州:广州中医药大学. 2002: 22-24.
[8] Xu S, Shi JJ, Zhu SD, Yang JG, Ni GB, Chen MT . The expression of cell apoptosis modulating gene protein in gastric mucosa of qi-yin deficiency syndrome of chronic gastritis. Zhongguo Yi Yao Xue Bao. 2002 ; 17 (6) : 338-340, 383. Chinese with abstract in English.
doi: 10.3969/j.issn.1673-1727.2002.06.007
徐珊, 石君杰, 朱曙东, 杨季国, 倪桂宝, 陈明涛 . 细胞凋亡调控基因蛋白在慢性胃炎气阴两虚证胃粘膜中的表达.中国医药学报. 2002; 17(6):338-340, 383.
doi: 10.3969/j.issn.1673-1727.2002.06.007
[9] Liu WJ . Study the relationship between typing of diagnosis based on an overall analysis of signs and symptoms of AD in traditional Chinese medicine and HLA-DR gene. Guangzhou: Guangzhou University of Chinese Medicine. 2006 : 43-45. Chinese with abstract in English.
刘文杰 . 特应性皮炎中医辨证分型与HLA-DR基因的相关性探讨.广州:广州中医药大学. 2006: 43-45.
[10] Lu C, Zhao LH, Xiao C, Jia HW, Zha QL, Yan XP, Wang JM, Zhang YZ, Yang WB, Zhou YW, Li S, Lu AP . Study the gene profile of peripheral CD4 + lymphocytes of patients with rheumatoid arthritis. Zhonghua Feng Shi Bing Xue Za Zhi. 2006; 10(7) : 438-439. Chinese.
doi: 10.3760/j:issn:1007-7480.2006.07.016
吕诚, 赵林华, 肖诚, 贾红伟, 查青林, 闫小萍, 王建明, 张英泽, 杨卫彬, Zhou YW, 李梢,吕爱平.类风湿关节炎患者外周血CD4+淋巴细胞基因表达谱研究探讨.中华风湿病学杂志. 2006; 10(7):438-439.
doi: 10.3760/j:issn:1007-7480.2006.07.016
[11] Lu C, Xiao C, Zhao LH, Zha QL, Yan XP, Wang JM, Zhang YZ, Zhou YW, Xu SJ, Li S, Lii AP . Comparison of gene profile of peripheral CD4 + lymphocytes in rheumatoid arthritis with cold and heat syndrome. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi. 2006; 12(2): 130-133. Chinese with abstract in English.
吕诚, 肖诚, 赵林华, 查青林, 闫小萍, 王建明, 张英泽, 周扬文, 徐世杰, 李梢, 吕爱平 . 寒热证候类风湿性关节炎患者外周血CD4+ T淋巴细胞基因表达谱初步探索.中国中医基础医学杂志. 2006; 12(2):130-133.
[12] Chen ZC, Xiao ZQ. Human disease proteomics. Beijing: Chemical Industry Press. 2006 : 3. Chinese.
陈主初, 肖志强 . 疾病蛋白质组学.北京: 化学工业出版社. 2006: 3.
[13] He Q. Analysis of the differential expression of serum proteome in essential hypertension patients with liver- yang hyperactivity and yin deficiency and yang excess syndromes. Beijing: Beijing University of Chinese Medicine. 2010 : 45-47. Chinese with abstract in English.
何青 . 髙血压病患者肝阳上亢､阴虚阳亢证候的血清蛋白质组学研究.北京:北京中医药大学. 2010: 45-47.
[14] Guo SZ. Research on the animal model of blood stasis ( myocardial ischemia ) and its related proteomics. Beijing: Beijing University of Chinese Medicine. 2007 : 76-85. Chinese with abstract in English.
郭淑贞.血瘀证( 心肌缺血 ) 动物模型及其相关蛋白质组学研究.北京:北京中医药大学. 2007: 76-85.
[15] Liu T. Research on the animal model of qi-deficiency and blood-stasis syndrome ( myocardial ischemia ) and its related proteome. Beijing: Beijing University of Chinese Medicine. 2007: 5-15. Chinese with abstract in English.
刘涛 . 气虚血瘀证(心肌缺血)动物模型及蛋白质组学研究.北京:北京中医药大学. 2007: 5-15.
[16] Wang XW. The standard of calculating diagnosis of syndrome differentiation by symptom factors in nasopharyngeal precancerous lesions and its related proteome studies. Changsha: Hunan University of Traditional Chinese Medicine. 2009: 50-53. Chinese with abstract in English.
王贤文 . 鼻咽癌前病变证素计量辨证规范及其相关蛋白质组学基础研究.长沙:湖南中医药大学. 2009: 50-53.
[17] Liu JL, Song JN , Lei Y. Differential plasma protein profiles in patients with hyperlipidemia &• atherosclerosis of different patterns of phlegm-stasis syndrome. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010; 30(5): 482-486. Chinese with abstract in English.
刘军莲, 宋剑南, 雷燕 . 血脂异常及动脉粥样硬化不同痰瘀证候血浆蛋白差异表达谱的研究.中国中西医结合杂志. 2010; 30(5):482-486.
[18] Nicholson JK, Lindon JC, Holmes E . ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica. 1999; 29(11) : 1181-1189.
doi: 10.1080/004982599238047
[19] Chu Y . Study of the essence of spleen qi deficiency based on metabonomics of the human plasma. Dalian: Dalian Medical University. 2009: 37-38. Chinese with abstract in English.
初艳 . 基于血浆代谢组学的脾气虚证.大连:大连医科大学. 2009: 37-38.
[20] Tong NN . Study on metabonomic profile of human salivary of the syndrome of damp and heat stagnating in spleen for chronic gastritis. Guangzhou: Guangzhou University of Chinese Medicine. 2006 : 24-31. Chinese with abstract in English.
童宁宁 . 慢性胃炎湿热蕴脾证唾液代谢组学的初步研究.广州:广州中医药大学. 2006: 24-31.
[21] Tao XM . Study on the model of kidney yang deficiency and its syndrome based on metabonomics. Shanghai: Shanghai Jiao Tong University. 2009 : 105. Chinese with abstract in English.
陶秀梅 .肾阳虚”模型及证候的代谢组学研究. 上海: 上海交通大学. 2009: 105.
[22] Zhang HS, Jia YH, Hua HY, Wan ZY, Guan SY, Cao SP, Cui K . Study on phlegm syndrome and blood stasis syndrome in coronary artery disease with angina pectoris based on metabolomics of urine. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi. 2010; 16(2): 126-128. Chinese.
张红栓, 贾钰华, 华何与, 万中原, 关山越, 曹世平, 崔凯 . 冠心病心绞痛痰浊证､血瘀证的尿液代谢组学研究.中国中医基础医学杂志. 2010; 16(2):126-128.
[23] Dong HQ . Study on modern scientific connotation of metabolomics of hypertension due to phlegm-dampness accumulation. Nanjing: Nanjing University of Traditional Chinese Medicine. 2009 : 31. Chinese with abstract in English.
董海琪 . 髙血压病痰湿壅盛证现代科学内涵的代谢组学研究.南京:南京中医药大学. 2009: 31.
[24] Zhu J . A metabonomic study on hypertension due to yin deficiency and yang excess. Nanjing: Nanjing University of Traditional Chinese Medicine. 2009 : 4-10. Chinese with abstract in English.
朱嘉 . 髙血压病阴虚阳亢证的代谢组学研究.南京:南京中医药大学. 2009: 4-10.
[25] Chen QW, Ling CQ . Serum metabonomics on yang deficiency of patients with primary liver cancer. Ningbo : The Third International Conference of Integrated Traditional Chinese and Western Medicine and Traditional Chinese Medicine and the 12th Academic Conference on Tumor in Traditional Chinese and Western Medicine. 2010 : 555-562. Chinese with abstract in English.
陈群伟, 凌昌全 . 原发性肝癌阳虚证患者血清代谢组学研究.宁波:第三届国际中医､中西医结合肿瘤学术交流大会暨第十二届全国中西医结合肿瘤学术大会. 2010: 555-562.
[26] Humphery-Smith I, Cordwell SJ, Blackstock WP . Proteome research : complementarity and limitations with respect to the RNA and DNA worlds. Electrophoresis. 1997 ; 18(18):1217-1242.
doi: 10.1002/elps.1150180804 pmid: 9298643
[27] Zhu S, Gao RL, Sui DJ . Genomics, proteomics and the essentialism of Zheng-hou. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi. 2002; 8(12): 19-20. Chinese with abstract in English.
doi: 10.3969/j.issn.1006-3250.2002.12.008
朱姝, 髙荣林, 隋殿军 . 基因组学､蛋白质组学与证候实质.中国中医基础医学杂志. 2002; 8(12):19-20.
doi: 10.3969/j.issn.1006-3250.2002.12.008
[28] Guan DY, Fang ZQ . Studies on the correlation between traditional Chinese medicine syndrome and genes: an overview and some reflections. Zhong Yi Za Zhi. 2005; 46(8): 569-571. Chinese.
doi: 10.3321/j.issn:1001-1668.2005.08.003
管冬元, 方肇勤 . 中医证候与基因相关性研究的现状与反思.中医杂志. 2005; 46(8):569-571.
doi: 10.3321/j.issn:1001-1668.2005.08.003
[1] Ming-min Xu, Pei Guo, Qing-yu Ma, Xuan Zhou, Yu-long Wei, Lu Wang, Yue Chen, Yu Guo. Can acupuncture enhance therapeutic effectiveness of antidepressants and reduce adverse drug reactions in patients with depression? A systematic review and meta-analysis. Journal of Integrative Medicine, 2022, 20(4): 305-320.
[2] Yen-Lin Chao, Yi-Ai Rau, Hong-Sheng Shiue, Jiun-Lin Yan, Yuan-Yun Tang, Shao-Wen Yu, Bo-Yan Yeh, Yen-Lung Chen, Tsung-Hsien Yang, Shu-Chen Cheng, Yi-Wen Hsieh, Hsin-Chia Huang, Fu-Kuang Tsai, Yu-Sheng Chen, Geng-Hao Liu. Using a consensus acupoints regimen to explore the relationship between acupuncture sensation and lumbar spinal postoperative analgesia: A retrospective analysis of prospective clinical cooperation. Journal of Integrative Medicine, 2022, 20(4): 329-337.
[3] Zeinab Vafaeipour, Bibi Marjan Razavi, Hossein Hosseinzadeh. Effects of turmeric (Curcuma longa) and its constituent (curcumin) on the metabolic syndrome: An updated review. Journal of Integrative Medicine, 2022, 20(3): 193-203.
[4] Ting-ting Lu, Cun-cun Lu, Mei-xuan Li, Li-xin Ke, Hui Cai, Ke-hu Yang. Reporting and methodological quality of meta-analyses of acupuncture for patients with migraine: A methodological investigation with evidence map. Journal of Integrative Medicine, 2022, 20(3): 213-220.
[5] Witoo Dilokthornsakul, Ramanya Kosiyaporn, Rattanamanee Wuttipongwaragon, Piyameth Dilokthornsakul. Potential effects of propolis and honey in COVID-19 prevention and treatment: A systematic review of in silico and clinical studies. Journal of Integrative Medicine, 2022, 20(2): 114-125.
[6] Deng-chao Wang, Miao Yu, Wen-xian Xie, Li-yan Huang, Jian Wei, Yue-hua Lei. Meta-analysis on the effect of combining Lianhua Qingwen with Western medicine to treat coronavirus disease 2019. Journal of Integrative Medicine, 2022, 20(1): 26-33.
[7] Mahlagha Dehghan, Alireza Ghanbari, Fatemeh Ghaedi Heidari, Parvin Mangalian, Mohammad Ali Zakerid. Use of complementary and alternative medicine in general population during COVID-19 outbreak: A survey in Iran. Journal of Integrative Medicine, 2022, 20(1): 45-51.
[8] Shuai Chen, Jin Hu, Deng-cheng Lu, Hong-yi Liu, Shan-shan Wei. Metabolomic characteristics of spontaneously hypertensive rats under chronic stress and the treatment effect of Danzhi Xiaoyao Powder, a traditional Chinese medicine formula. Journal of Integrative Medicine, 2022, 20(1): 73-82.
[9] Jun-peng Yao, Li-ping Chen, Xian-jun Xiao, Ting-hui Hou, Si-yuan Zhou, Ming-min Xu, Kai Wang, Yu-jun Hou, Lin Zhang, Ying Li. Effectiveness and safety of acupuncture for treating functional constipation: An overview of systematic reviews. Journal of Integrative Medicine, 2022, 20(1): 13-25.
[10] Hyongjun Jeon, Hee-Young Kim, Chang-Hwan Bae, Yukyung Lee, Sungtae Koo, Seungtae Kim. Korean red ginseng decreases 1-methyl-4-phenylpyridinium-induced mitophagy in SH-SY5Y cells. Journal of Integrative Medicine, 2021, 19(6): 537-544.
[11] Meng-ya Shan, Ying Dai, Xiao-dan Ren, Jing Zheng, Ke-bin Zhang, Bin Chen, Jun Yan, Zi-hui Xu. Berberine mitigates nonalcoholic hepatic steatosis by downregulating SIRT1-FoxO1-SREBP2 pathway for cholesterol synthesis. Journal of Integrative Medicine, 2021, 19(6): 545-554.
[12] Shu-yi Chen, Qun-wei Chen, Liu-mei Shou, Hong Pan, Shan-ming Ruan, Zhe-hao Liang, Qi-jin Shu. Stevens-Johnson syndrome/toxic epidermal necrolysis successfully treated with Chinese herbal medicine Pi-Yan-Ning: A case report. Journal of Integrative Medicine, 2021, 19(6): 555-560.
[13] Yi Yuan, Rui-Ting Wang, Jun Xia, Hui-Juan Cao. Interventions for preventing influenza: an overview of Cochrane systematic reviews and a Bayesian network meta-analysis. Journal of Integrative Medicine, 2021, 19(6): 503-514.
[14] Mao-xing Pan, Chui-yang Zheng, Yuan-jun Deng, Kai-rui Tang, Huan Nie, Ji-qian Xie, Dong-dong Liu, Gui-fang Tu, Qin-he Yang, Yu-pei Zhang. Hepatic protective effects of Shenling Baizhu powder, a herbal compound, against inflammatory damage via TLR4/NLRP3 signalling pathway in rats with nonalcoholic fatty liver disease . Journal of Integrative Medicine, 2021, 19(5): 428-438.
[15] Liang Ding, Xin-you Zhang, Di-yao Wu, Meng-ling Liu. Application of an extreme learning machine network with particle swarm optimization in syndrome classification of primary liver cancer. Journal of Integrative Medicine, 2021, 19(5): 395-407.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Jin-rong Fu. Establishment of multivariate diagnosis and treatment system of modern gynecology of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 22-24
[2] Hao Li, Ming-jiang Yao, Wen-ming Zhao, Jie Guan, Lin-lin Cai, Ling Cui. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment. Journal of Chinese Integrative Medicine, 2008, 6(1): 25-31
[3] Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[4] SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5] Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[6] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7] Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[8] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[9] Gui Yu, Jie Wang. Thinking on building the network cardiovasology of Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1206-1210
[10] Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239
Journal of Integrative Medicine, ISSN: 2095-4964 CN 31-2083/R
Copyright © Journal of Integrative Medicine
Powered by Beijing Magtech Co. Ltd
沪公网安备31010602003416号      沪ICP备18017633号-3