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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (4): 303-306.doi: 10.3736/jcim20050416

• Original Experimental Research • Previous Articles     Next Articles

Experimental study on anti-inflammatory and analgesic effects of Yitieling Paste

Li-jun Xu1,Yong-hong Hu2,Fu-er Lu1,Xin Zou1   

  1. 1. Institute of Integrated Traditional Chinese and Western Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430030, China
    2. Department of Traditional Chinese Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430030, China
  • Received:2004-03-16 Online:2005-07-20 Published:2005-07-20
  • Contact: Li-jun Xu E-mail:xulijunwxr@sina.com

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Objective

To observe the anti-inflammatory and analgesic effects of Yitieling Paste (YTLP).

Methods

YTLP and aspirin (as a control drug) were introduced to treat the edematous ears of mice induced by xylene and swollen toes of mice induced by carrageenin, and to relieve the pain in mice induced by heat and acetic acid. The swelling degree, pain threshold and body distortions were measured.

Results

The repression rates of the ear edema in groups of YTLP of high and low dosages and the aspirin group were 67.92%, 52.52% and 58.28%, respectively. The repression rate of the toe swelling in YTLP high dosage group was higher than that of the aspirin group, which was higher than that of the YTLP low dosage group. The results of analgesic effect of the three YTLP-treated groups showed that with the increase of dosage, the pain thresholds were higher and higher, and the body distortions were lower and lower. The pain thresholds of high and medium dosage YTLP groups were near to the aspirin group.

Conclusion

YTLP possesses a strong anti-inflammatory and analgesic effect.

Key words: Yitieling Paster, Anti-inflammation, Analgesia

CLC Number: 

  • R289.5

Tab 1

Ear edema of mice induced by xylene in different groups （$\bar{x}$±s）"

Group n Weight difference of two ears （mg） Inhibition rate （%）
Model 10 8.51±3.20
Aspirin （0.2 g/kg） 10 3.55±1.73** 58.28
YTLP （2.4 g/kg） 10 2.73±1.28**△ 67.92
YTLP （1.2 g/kg） 10 4.04±2.18** 52.52

Tab 2

Toe swelling of rats induced by carrageenin in different groups （$\bar{x}$±s）"

Group n Toe swelling （mm） Inhibition rate （%）
1 h 2 h 3 h 4 h 1 h 2 h 3 h 4 h
Model 10 2.50±0.29 2.85±0.37 3.07±0.44 2.77±0.39
Aspirin （0.1 g/kg） 10 1.98±0.16** 2.08±0.22 ** 1.82±0.38** 1.65±0.35** 20.8 27.0 40.7 40.3
YTLP （1.5 g/kg） 10 1.83±0.41** 1.87±0.16** 1.69±0.33** 1.54±0.31** 26.8 34.4 45.0 44.4
YTLP （0.75 g/kg） 10 2.30±0.39 2.20±0.47** 2.10±0.51** 1.87±0.44** 8.0 22.8 31.6 32.5

Tab 3

PGE2, LI-1 and TNF-α in swollen toes of rats induced by carrageenin in different groups （$\bar{x}$±s）"

Group n PGE2 (ng/L) IL-1 (μg/L) TNF-α (μg/L)
Model 10 0.210±0.021 0.16±0.045 0.66±0.164
Aspirin （0.1 g/kg） 10 0.184±0.035* 0.17±0.029 0.74±0.261
YTLP （1.5 g/kg） 10 0.130±0.020**△△ 0.15±0.050 0.74±0.256
YTLP （0.75 g/kg） 10 0.220±0.034 0.14±0.055 0.67±0.204

Tab 4

Pain threshold of mice in different groups （$\bar{x}$±s, s）"

Group n Pain threshold
before administration		 Pain threshold after administration
0.5 h 1 h 2 h 4 h 6 h
Model 10 17.70±3.07 17.93±3.25 18.52±2.45 18.98±2.24 18.52±2.54 19.53±2.06
Aspirin （0.6 g/kg） 10 18.63±3.70 25.19±3.42** 26.52±3.70 ** 28.10±4.07 ** 28.19±3.97 ** 25.78±4.09**
YTLP （2.4 g/kg） 10 18.80±4.72 18.24±4.23 23.12±4.22** 26.79±3.96**△△ 29.76±4.28 **△△ 29.14±3.94**△
YTLP （1.2 g/kg） 10 18.25±5.52 18.89±5.17 22.42±4.92* 25.66±5.03**△△ 28.33±5.37 **△△ 26.13±4.16**△△
YTLP （0.6 g/kg） 10 17.62±3.59 17.81±3.22 18.57±3.37 20.92±3.04 23.54±3.15* 23.03±2.52*

Tab 5

Body-distortions of mice in different groups （$\bar{x}$±s）"

Group n Body-distortions
Model 10 25.6±3.13
Aspirin （0.6 g/kg） 10 5.6±1.78**
YTLP （2.4 g/kg） 10 11.0±2.18**△△
YTLP （1.2 g/kg） 10 14.9±2.08**△△
YTLP （0.6 g/kg） 10 20.3±3.09**△△
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